Bone Program

The Endocrinology Pediatric Bone Program, a part of the Division of Endocrinology, Diabetes and Metabolism at Children’s Hospital Los Angeles, is committed to the care and services for children with bone disease. Our mission is to develop, implement and promote innovative and effective strategies to improve outcomes for children with both common and rare metabolic bone disorders. Our team of bone specialists also has expertise in caring for children with genetic and acquired bone disease.

We take pride in focusing on patient care, clinical research and patient-family advocacy to provide our patients the most comprehensive care possible at one location. Since 2010, we have seen and followed over 500 patients with a bone diagnosis.

  • Disorders Treated
  • Clinical Trials and Research
  • Education and Advocacy

Common Metabolic Bone Disorders:

  • Rickets
  • Osteogenesis Imperfecta
  • Hypoparathyroidism

Rare Metabolic Bone Disorders:

  • Hypophosphatasia
  • Osteopetrosis
  • Abnormal Calcium and Phosphate Metabolism
  • Abnormal Vitamin D and Parathyroid Disorders
  • Childhood Osteoporosis

Genetic and Acquired Bone Disorders:

  • Paget's disease
  • Low Bone Density Associated with Chronic Diseases
  • Multiple Fractures with No Known Etiology
  • Patients with Family History of Metabolic Bone Disease
  • Growth with Bone Disorders
  • Low Bone Density for Age
  • Multiple Fractures without Significant Trauma

Clinical Trials

Current research initiatives include two on-going Clinical Trials treating adults and children suffering from X-Linked Hypophosphatemia (XLH) with a drug that is on its way to FDA approval and possibly becoming the new gold standard in XLH treatment. Thank you for your interest and we would love to work with you or serve you as a patient. If you have any questions please don’t hesitate to reach out to our Bone Team.

Investigator Initiated Research

Investigator Initiated research study headed up by our very own 2nd year fellow Sara Akhtar MD to better understand the pathogenesis of RANKL on patients with metabolic bone diseases in order to better understand the pathogenesis of RANKL and potential treatment plan for these patients.

Dr. Duke and his Bone Team continue their dedication to social awareness and not-for-profit outreach through their annual Walk for Kids Growth walk and Bone Family Picnic. These events provide a safe space for families, patients and like-minded medical professionals to come together to provide education, resources and supportive comradery. Letting patients and families know they are not alone with the challenges most face with these rare diseases is always at the forefront of the Bone Team’s aspiring goals.