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DISCOVERIES AND INNOVATION

Well, That’s a First!

California’s first Surgeon General, Dr. Nadine Burke Harris, visits Children’s Hospital Los Angeles

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One of the reasons to conduct research at a pediatric institution is that getting evidence-based answers sooner can lead to real changes in health outcomes for children. These benefits persist throughout an individual’s lifetime.

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CHLA Scientists Develop Breakthrough In Vitro Model

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Scientists at Children’s Hospital Los Angeles develop first physiologically-accurate in vitro model of the human kidney glomerulus, representing a milestone in the field of kidney disease research

Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease (CKD) are characterized by a reduced...

Mental Healthcare ... in the NICU?

Bringing a baby into the world involves many firsts – mothers and fathers are discovering their new roles, babies are learning what it means to live outside the womb, and the family is forging a relationship and bonding. But what happens when this time of uncertainty is complicated by medical issues?

Many infants born premature or with other complications often forego their first weeks or months at home for a stay in...

RESEARCH COMMUNITY

Peter Chiarelli, MD, PhD Wins Prestigious Award for Nanoparticle Research

When it comes to pediatric brain cancers, research and treatments have made great strides. But some cancers do not respond to conventional treatments or grow deep within delicate areas of the brain, where surgical removal can be impossible.

Peter Chiarelli, MD, PhD, has received an award to support his research in...

Precision Medicine for Pediatric Cancer

Research performed over the last several decades has led to an increased understanding of the genetics of cancer. The clinical application of this knowledge for pediatric cancer has lagged behind studies performed for adults. In a perspectives article published in the prestigious journal Science, Dr. Jaclyn Biegel, from Children’s Hospital Los...

Children’s Hospital Los Angeles Hosts 10th Annual St. Baldrick’s Head Shave Event

For the tenth year in a row, doctors, family members, and the Los Angeles community came together to support cancer research at the St. Baldrick’s Annual Head Shave Event. This year’s event held particular significance for one of CHLA’s doctors, Robert Seeger, MD, MS (pictured below), who shaved his head for the 10th and final time.

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NEWS

Glomerulus in vitro
A Leap Forward in Kidney Disease Research
Scientists at Children’s Hospital Los Angeles develop first physiologically-accurate in vitro model of the human kidney glomerulus, representing a milestone in the field of kidney disease research. Kidneys work to constantly filter blood and remove toxins from the body....
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Mark Frey, PhD, Receives $1.7M Grant to Study How the GI Tract Repairs Itself After Injury
Chemotherapy and radiation target cancer cells but these treatments produce unwanted side effects on healthy tissue. The intestines are particularly sensitive to this toxicity. A better understanding of how intestinal tissue repairs itself in response to injury could help...
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Children’s Hospital Los Angeles Awarded $3 Million to Study How Baby’s First Flu Exposure Affects Later Vaccine Response
Pediatricians have observed that a baby’s early infection with flu impacts their later response to the virus as well as how protected they are by vaccination. To better understand how this “immunological imprinting” occurs, the National Institute of Allergy and Infectious...
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Research videos

  • Leaders in Pediatric Health Through Scientific Discovery

    Children’s Hospital Los Angeles is ranked 5th nationally in US News and World Report’s list of top children’s hospitals. This recognized excellence in patient care would be impossible without the intimate relationship shared with our research enterprise. Watch as Chief Scientific Officer, Pat Levitt, PhD, introduces our research themes and discusses CHLA’s position as a leader in pediatric health through our scientific discoveries.

  • Family Philanthropy Benefits Research on Nephrology

    A documentary film about the GOFARR Fund for Children’s Hospital Los Angeles was recently screened at the Sun Valley Film Festival for Future Filmmakers. The film, “Believe: The Story of the GOFARR Fund,” was made by Amanda Schenkman and tells the story about her twin brother Gabriel and his journey with a congenital kidney condition.

    The Schenkman Family Fund supports nephrology research at CHLA overseen by Roger De Filippo, MD, FACS, FAAP and Laura Perin, PhD. At the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, De Filippo and Perin focus on the development of new stem cell therapeutics and other techniques for organ regeneration.

  • Using Gene-Editing to Cure Type 1 Diabetes

    Senta Georgia, PhD, is creating new insulin-producing cells using CRISPR gene-editing technology in her work to cure genetic forms of diabetes.

  • Can Virtual Reality Help Manage Pain?

    Researchers at CHLA are studying the use of virtual reality to reduce pain in children and adolescents undergoing painful medical procedures. Jeffrey Gold, PhD, a clinical psychologist and director of the Pediatric Pain Management Clinic, explains his research.

  • Using Virtual Reality to Train Physicians for Pediatric Emergencies

    CHLA is using virtual reality to build skills and confidence to prepare medical students for real-life emergencies. Joshua Sherman, MD, an emergency medicine physician at CHLA, explains how.

  • Protecting the Brains of Infants with Therapeutic Cooling

    Investigators at Children's Hospital Los Angeles are using therapeutic cooling to protect the brains of newborns deprived of oxygen during birth. Jessica Wisnowski, PhD, and Tai-Wei Wu, MD, explain the process and why it works.