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DISCOVERIES AND INNOVATION

What Makes a Cell Turn Cancerous?

A cancer gene called MYCN (red) appears in high levels in cone cells (green). These cone cells can go on to form retinoblastoma tumors. Image provided by Dr. Hardeep Singh, Children’s Hospital Los Angeles.

Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age and accounts for approximately 4% of childhood cancers. If not diagnosed early, retinoblastoma may result...

Our #WomenInScience Rock!

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They wear lab coats in place of capes, safety goggles instead of masks, and wield pipets - not swords. But they are still our heroes.

At CHLA, we are proud to honor women in science for International Women’s Day!

Please visit www.chla.org/womeninscience to learn about 6 talented women who are saving lives from the laboratory.

Solving the Mystery of the Silent Stroke

When blood flow is blocked in the brain, a small portion of brain tissue starves and dies – this is known as a stroke. By the time a patient with Sickle Cell Disease (SCD) is 30 years old, he or she has a 50% chance of having a stroke. Children’s Hospital Los Angeles physician and investigator John Wood is out to discover why. He has dedicated his career to...

RESEARCH COMMUNITY

Enough! Time for Tech to Help Kids with Autism

1 out of 68 children in the United States will be diagnosed with an Autism Spectrum Disorder (ASD). The prevalence of an ASD diagnosis grew by 72 percent between 2007 and 2011. Tech-based interventions targeted to children with autism have the potential to help solve challenges with social skills, repetitive behaviors, speech and nonverbal communications.

At the South by Southwest Interactive Healthcare...

American Pediatric Society 2018 Elected Members From CHLA

(Left to Right) Douglas Nordli, Jr., MD, CHLA Chief of Pediatric Neurology; Robert E. Shaddy, MD, CHLA Pediatrician-in-Chief; Rohit Kohli, MBBS, MS, CHLA Chief of Gastroenterology, Hepatology, and Nutrition.

This year, three physician researchers at Children’s Hospital Los Angles representing subspecialties in gastroenterology, neurology and cardiology,  have been elected to the membership of...

David Warburton is among the 2017 AAAS Elected Fellows Recognized for Advancing Science in the Section of Medical Sciences

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David Warburton, MD, has been elected a 2017 Fellow of the American Association for the Advancement of Science (AAAS) in recognition his contributions to innovation, education, and scientific leadership in the Section of Medical Sciences...

NEWS

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Considering the implications of precision medicine for diagnosis and treatment of pediatric cancers   Research performed over the last several decades has led to an increased understanding of the genetics of cancer. The clinical application of this knowledge for...
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CHLA researcher receives $1.6M grant to study cellular and genetic changes that underlie retinoblastoma. Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age and accounts for approximately 4% of childhood cancers. If not diagnosed...
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Children’s Hospital Los Angeles has been awarded a $1.36M grant from The Leona M. and Harry B. Helmsley Charitable Trust to adapt a patient-driven model of care that Clinical Diabetes Director, Jennifer Raymond, MD, MCR, developed to increase treatment compliance among difficult...

Research videos

  • Family Philanthropy Benefits Research on Nephrology

    A documentary film about the GOFARR Fund for Children’s Hospital Los Angeles was recently screened at the Sun Valley Film Festival for Future Filmmakers. The film, “Believe: The Story of the GOFARR Fund,” was made by Amanda Schenkman and tells the story about her twin brother Gabriel and his journey with a congenital kidney condition.

    The Schenkman Family Fund supports nephrology research at CHLA overseen by Roger De Filippo, MD, FACS, FAAP and Laura Perin, PhD. At the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, De Filippo and Perin focus on the development of new stem cell therapeutics and other techniques for organ regeneration.

  • Using Gene-Editing to Cure Type 1 Diabetes

    Senta Georgia, PhD, is creating new insulin-producing cells using CRISPR gene-editing technology in her work to cure genetic forms of diabetes.

  • Can Virtual Reality Help Manage Pain?

    Researchers at CHLA are studying the use of virtual reality to reduce pain in children and adolescents undergoing painful medical procedures. Jeffrey Gold, PhD, a clinical psychologist and director of the Pediatric Pain Management Clinic, explains his research.

  • Using Virtual Reality to Train Physicians for Pediatric Emergencies

    CHLA is using virtual reality to build skills and confidence to prepare medical students for real-life emergencies. Joshua Sherman, MD, an emergency medicine physician at CHLA, explains how.

  • Protecting the Brains of Infants with Therapeutic Cooling

    Investigators at Children's Hospital Los Angeles are using therapeutic cooling to protect the brains of newborns deprived of oxygen during birth. Jessica Wisnowski, PhD, and Tai-Wei Wu, MD, explain the process and why it works.