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DISCOVERIES AND INNOVATION

Precision medicine prompts a 180 ̊ change for Sophia’s rare cancer

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The sidewalk was smooth and the sky was clear, so Sophia Cabrera took out her skateboard and went for a ride. Before she could return home, she fell, landed in a heap and broke her arm. Funny thing is, she and her family couldn’t have been happier. Falls and fractures are regular mishaps for an 8-year-old, and regular was something Sophia hadn’t been in a long time.

Only a year...

Stem cells may help repair hypoplastic left heart syndrome

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Baby Jasmine was born in late December with hypoplastic left heart syndrome (HLHS) and had her first open-heart surgery at five days old. She is enrolled in the groundbreaking clinical trial at Children’s Hospital Los Angeles. 

New therapy could boost organ repair and delay or even prevent heart failure in children

Children born with...

Using Stem Cells to Repair Tiny Hearts

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A protein lining the inner layer of the heart. The protein is required for heart muscles to proliferate during development.

Ram Kumar Subramanyan, MD, PhD, brings a unique point of view to the laboratory, where his goal is to one day use stem cells to create replacement parts for children with heart defects.

“I...

RESEARCH COMMUNITY

Enough! Time for Tech to Help Kids with Autism

1 out of 68 children in the United States will be diagnosed with an Autism Spectrum Disorder (ASD). The prevalence of an ASD diagnosis grew by 72 percent between 2007 and 2011. Tech-based interventions targeted to children with autism have the potential to help solve challenges with social skills, repetitive behaviors, speech and nonverbal communications.

At the South by Southwest Interactive Healthcare...

American Pediatric Society 2018 Elected Members From CHLA

(Left to Right) Douglas Nordli, Jr., MD, CHLA Chief of Pediatric Neurology; Robert E. Shaddy, MD, CHLA Pediatrician-in-Chief; Rohit Kohli, MBBS, MS, CHLA Chief of Gastroenterology, Hepatology, and Nutrition.

This year, three physician researchers at Children’s Hospital Los Angles representing subspecialties in gastroenterology, neurology and cardiology,  have been elected to the membership of...

David Warburton is among the 2017 AAAS Elected Fellows Recognized for Advancing Science in the Section of Medical Sciences

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David Warburton, MD, has been elected a 2017 Fellow of the American Association for the Advancement of Science (AAAS) in recognition his contributions to innovation, education, and scientific leadership in the Section of Medical Sciences...

NEWS

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Less-toxic lymphoid regimens are more likely to obtain remission in mixed phenotype acute leukemia (MPAL) A study at Children’s Hospital Los Angeles is shedding new light on the best therapeutic approach for a rare and aggressive leukemia called mixed phenotype acute...
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Stress and other factors can trigger immune response A landmark study published in the Journal of Neuroscience on February 26 reveals that activation of a pregnant mother’s immune system can affect her baby’s brain development. A team of researchers led by Bradley Peterson,...
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Children’s Hospital Los Angeles one of 25 sites in international study of larotrectinib Three quarters of patients, both adults and children, with a variety of advanced cancers occurring in different sites of the body responded to larotrectinib, a novel therapy that targets a...

Research videos

  • Using Gene-Editing to Cure Type 1 Diabetes

    Senta Georgia, PhD, is creating new insulin-producing cells using CRISPR gene-editing technology in her work to cure genetic forms of diabetes.

  • Can Virtual Reality Help Manage Pain?

    Researchers at CHLA are studying the use of virtual reality to reduce pain in children and adolescents undergoing painful medical procedures. Jeffrey Gold, PhD, a clinical psychologist and director of the Pediatric Pain Management Clinic, explains his research.

  • Using Virtual Reality to Train Physicians for Pediatric Emergencies

    CHLA is using virtual reality to build skills and confidence to prepare medical students for real-life emergencies. Joshua Sherman, MD, an emergency medicine physician at CHLA, explains how.

  • Protecting the Brains of Infants with Therapeutic Cooling

    Investigators at Children's Hospital Los Angeles are using therapeutic cooling to protect the brains of newborns deprived of oxygen during birth. Jessica Wisnowski, PhD, and Tai-Wei Wu, MD, explain the process and why it works.