Cardiogenomics

The Center for Cardiogenomics at Children’s Hospital Los Angeles is a multidisciplinary collaboration between the hospital’s divisions of cardiology and medical genetics, dedicated to providing excellent care for pediatric patients with suspected genetic or inherited cardiac conditions.

Cardiovascular diseases are the leading cause of death in the United States. Over the past two decades, significant advances have been made in understanding the molecular pathology of inherited cardiac conditions. There are hundreds of genes associated with cardiac disease.

Conditions Treated

The Center for Cardiogenomics welcomes all patients with suspected inherited cardiac disease, and offers cardiac and genetic testing for a wide range of conditions, including:

Cardiomyopathies

  • Hypertrophic cardiomyopathy
  • Restrictive cardiomyopathy
  • Arrhythmogenic cardiomyopathy
  • Dilated cardiomyopathy
  • Left ventricular noncompaction

Arrhythmic syndromes

  • Long QT syndrome
  • Brugada syndrome
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT)
  • Short QT syndrome

Vascular disorders

  • Marfan syndrome
  • Ehler-Danlos syndrome
  • Loeys-Dietz syndrome

The Center offers patients with suspected or known inherited cardiac disease:

  • A comprehensive cardiac and genetic workup, including genetic testing when necessary
  • Counseling regarding the cardiac and noncardiac manifestations of the inherited disease
  • Recommendations for their physician on the ongoing management of their condition
  • Counseling and genetic testing to detect inherited cardiac conditions in family members