Diabetes and Obesity Program
Type 1 Diabetes
While insulin injections and other pharmaceuticals help patients manage their diabetes, there is no definitive cure. Replacement of lost insulin-secreting cells may be the key to a cure. The lab of Senta Georgia, PhD, uses a three-pronged approach to design novel strategies for making new insulin-secreting cells, studying the basic biology of insulin-secreting cells and translating that knowledge into potential cell replacement strategies for type 1 diabetes patients.
Investigator: Senta Georgia, PhD
- Matveyenko AV, Singh I, Shin BC, Georgia S, Devaskar SU. Differential effects of prenatal and postnatal nutritional environment on β-cell mass development and turnover in male and female rats. Endocrinology. 2010;151(12):5647-56. PubMed Link.
- Matveyenko AV, Georgia S, Bhushan A, Butler PC. Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010;299(5):E713-20. PubMed Link.
- Georgia S, Hinault C, Kawamori D, et al. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodants. Diabetes. 2010;59(4):987-96. PubMed Link.
De Filippo Laboratory
The lab of Roger De Filippo, MD , focuses on new uses of stem cells and other techniques for organ regeneration and cell therapeutics. Current research includes new stem cell studies for heart disease and diabetes. The goal is to search for potential applications that can be used to prevent these diseases and/or significantly delay the damage they cause.
Investigator: Laura Perin, PhD
Select PublicationMilanesi A, Lee JW, Xu Q, Perin L, Yu JS. Differentiation of nestin-positive cells derived from bone marrow into pancreatic endocrine and ductal cells in vitro. J Endocrinol. 2011;2009(2):193-201. PubMed Link.
Early Life Determinants of Obesity and Diabetes
There is growing appreciation that developmental programming of neuroendocrine systems by the perinatal environment may cause obesity and diabetes. The Sebastien G. Bouret, PhD Lab is exploring the role of perinatal hormones in influencing the development of hypothalamic pathways involved in appetite regulation.
Investigator: Sebastien Bouret, PhD