CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Acute Lymphoblastic Leukemia (ALL)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

Acute Lymphoblastic Leukemia (ALL) (CAR T ALL)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

Acute Lymphoblastic Leukemia (ALL) (Newly Diagnosed ALL)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

ADHD-Attention Deficit Hyperactivity Disorder
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

Anxiety
A Sequential Multiple Assignment Randomized Trial (SMART) Assessing Medication and CBT Sequencing Strategies in the Treatment of Predominantly Ethnic Minority, Underserved Youth with Anxiety Disorders 
Clinical Trials .Gov Identifier: NCT04760275Investigator: Bradley Peterson, MD

Autism Spectrum Disorders (ASD)
Characterization of Brain Network Dynamics Using Multi-Modal Approaches in Infant Siblings of Children with Autism Spectrum Disorders
Clinical Trials .Gov Identifier: NAInvestigator: Sahana Nagabhushan Kalburgi, PhD, &, Pat Levitt, PhD

Clinical and Molecular Characterization of Autism Spectrum Disorder and Related Neurodevelopmental Disorders
Clinical Trials .Gov Identifier: N/AInvestigator: Bridget Fernandez, MD

Ophthalmologic disorders and eye tracking in children with autism spectrum disorder (ASD)
Clinical Trials .Gov Identifier: N/AInvestigator: Dr. Melinda Chang, MD

Brain Development
MR Imaging Perinatal Brain Injury: Fetal Substudy
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Jodie Votava-Smith

Brain Tumor
Treatment-related CNS Injury and Cerebral Blood Flow in Children with Posterior Fossa Brain Tumors
Clinical Trials .Gov Identifier: NAInvestigator: Mary Baron Nelson

CAH
A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase Deficiency
Clinical Trials .Gov Identifier: NCT03548246Investigator: Mitchell Geffner, MD

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment
Clinical Trials .Gov Identifier: NCT04490915Investigator: Mimi Kim, MD

Effects of Androgen Excess on Lipid Distribution in Congenital Adrenal Hyperplasia
Clinical Trials .Gov Identifier: NAInvestigator: Mimi Kim, MD

Cardiology
Advanced MR Imaging of Perinatal Brain Injury: Correlation with Neurocognitive Outcome
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Ashok Panigrahy

Correlation of Neonatal Brain Imaging and Neurocognitive Assessment (Fetal Sub-study: Congenital Heart Disease patients and Control patients)
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Jodie Votava-Smith

Cerebral Palsy
Bone deficits and mechanical loading in ambulatory cerebral palsy
Clinical Trials .Gov Identifier: NAInvestigator: Tishya Wren, PhD

Chronic Anemia Syndromes (sickle cell disease and thalassemia)
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia
Clinical Trials .Gov Identifier: NAInvestigator: John Wood, MD

Congenital heart malformations
Prospective, non-randomized, open label clinical study to assess the feasibility of the Bioabsorbable pulmonary valved conduit in subjects undergoing Right Ventricular Outflow Tract (RVOT) reconstruction
Clinical Trials .Gov Identifier: NCT03022708Investigator: Cynthia Herrington, MD

COVID (SARS-CoV-2)
DIVINCI : Dissection of Influenza Vaccination and Infection for Childhood Immunity
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Pia Pannaraj

Household Exposure and Respiratory Virus Transmission and Immunity Study
Clinical Trials .Gov Identifier: NAInvestigator: Pia Pannaraj, MD

Crohn's Disease
Safety of FMT in maintenance of pediatric Crohn's disease
Clinical Trials .Gov Identifier: NCT03194529Investigator: Sonia Michail, MD

Down Syndrome
Non-Invasive Screening for Cerebrovascular Disease in Down Syndrome
Clinical Trials .Gov Identifier: NAInvestigator: Jonathan D. Santoro, MD

Eczema (AD)
A PHASE 2/3 STUDY INVESTIGATING THE PHARMACOKINETICS, SAFETY, AND EFFICACY OF DUPILUMAB IN PATIENTS AGED ≥6 MONTHS TO <6 YEARS WITH SEVERE ATOPIC DERMATITIS
Clinical Trials .Gov Identifier: NCT03346434Investigator: Peck Ong, MD

An Open-Label, Pilot Pharmacokinetic Study of INCB018424 Phosphate Cream in Pediatric Subjects With Atopic Dermatitis
Clinical Trials .Gov Identifier: NAInvestigator: Peck Ong, MD

Effect of Dupilumab (anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis - ATOPIC DERMATITIS RESEARCH NETWORK PROTOCOL-ADRN 09
Clinical Trials .Gov Identifier: NCT03389893Investigator: Peck Ong, MD

External Ventricular Drainage (EVD)
Non-Invasive Validation of an Inegrated Multi-Sensor Platform for Quantitive Monitoring of Intracranial Pressure, Cerebrospinal Fluid Flow, and Ventricular Catheter Patency
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Gordon J. McComb

Extubation failure in newborn infants
A study of incidence of upper airway obstruction and other risk factors of extubation failure in newborn infants
Clinical Trials .Gov Identifier: NAInvestigator: Narayan Prabhu Iyer

GI / Pancreas
Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
Clinical Trials .Gov Identifier: NCT03081182Investigator: Yuhua Zheng, MD

Glucocorticoid-Induced Osteoporosis (GIOP)
A phase 3 randomized, double-blind, placebo-controlled, Parallel-group Study to evaluate the safety and efficacy of Denosumab / Prolia in Pediatric Subjects with Glucocorticoid-Induced Osteoporosis
Clinical Trials .Gov Identifier: NCT03164928Investigator: Anna Ryabets-Lienhard, DO

Healthy Adults Planning to Receive the Ty21a Typhoid Vaccine
Impact of the gut microbiome on response to oral typhoid vaccine in healthy adults
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Pia Pannaraj

Healthy Baby Development
Scalable Measurement and Clinical Deployment of Mitochondrial Biomarkers of Toxic Stress
Clinical Trials .Gov Identifier: NAInvestigator: Pat Levitt, PhD

Healthy Controls
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

Healthy development, premature infants, postpartum depression
Healthy Development and Resiliency
Clinical Trials .Gov Identifier: NAInvestigator: Pat Levitt, PhD

Healthy Mothers and their Healthy Infants Needed
Characterization of the breast milk, infant oral and gut microbiomes in multiple geographic locations; role in immune development and response to oral rotavirus vaccine
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Pia Pannaraj

Healthy Preterm Infants Needed
A Phase 2b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants
Clinical Trials .Gov Identifier: NCT02878330Investigator: Dr. Pia Pannaraj

Healthy Subjects Needed
(Cis-gender/Unrelated Controls) Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

(Healthy Controls) Assessment of Risk Factors for Injury in the Pediatric Athlete
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Tishya Wren

(Healthy Controls) Brain blood flow and its response to changes to inhaled oxygen levels in subjects with and without sickle cell disease
Clinical Trials .Gov Identifier: NAInvestigator: Dr. John C. Wood

(Healthy Controls) Head Acceleration and Concussion Study
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

(Healthy Controls) Neuroimaging: Emotions and Appetite Testing Study
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Mimi Kim

(Healthy Fetus) Correlation of Neonatal Brain Imaging and Neurocognitive Assessment (Fetal Sub-study: Congenital Heart Disease patients and Control patients)
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Jodie Votava-Smith

(Healthy Pregnancy) Characterizing placental function in utero using MR imaging
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Vidya Rajagopalan

(Healthy Volunteers) Precision Medicine: All of Us Research Program
Clinical Trials .Gov Identifier: Please visit this website to learn more about the study: https://allofus.nih.gov/Investigator: Daniella Meeker, PhD - USC Department of Preventive Medicine

Healthy Subjects Needed (Healthy Pregnancy)
The Sweet PEA Study: a pilot study of the impact of diet during pregnancy on maternal and infant metabolic health
Clinical Trials .Gov Identifier: NCT04674033Investigator: Michael I Goran, PhD

Hepatitis B
A Randomized, Double-Blind Evaluation of the Pharmacokinetics, Safety, and Antiviral Efficacy of Tenofovir Alafenamide (TAF) in Adolescents with Chronic Hepatitis B Virus Infection (GS-US-320-1092)
Clinical Trials .Gov Identifier: NCT02932150Investigator: Chuan-Hao Lin, MD

Hydrocephalus
Novel Biomarker Investigation for Patients Undergoing CSF Shunt Infection Treatment
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Tamara Simon

Hypoplastic Left Heart Syndrome
Phase I safety of autologous umbilical cord blood derived mononuclear cells during surgical Stage II palliation of Hypoplastic Left Heart Syndrome
Investigator: Ram Kumar Subramanyan, MD

hypoxic-­ischemic encephalopathy (HIE)
HIGH DOSE ERYTHROPOIETIN FOR ASPHYXIA AND ENCEPHALOPATHY A randomized, placebo-­controlled, double-­masked 500 -­ subject clinical trial of erythropoietin for the treatment of neonatal hypoxic-­ischemic encephalopathy (HIE)
Clinical Trials .Gov Identifier: NAInvestigator: Tai-Wei Wu

IBD
A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of Humira® (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn's Disease (CD)
Clinical Trials .Gov Identifier: NAInvestigator: Hillel Naon, M.D

ImproveCareNow
Clinical Trials .Gov Identifier: NAInvestigator: Hillel Naon, M.D

ICD9/10 diagnostic codes corresponding with chronic illness/disability from 10 subspecialty clinics
A Qualitative Study of Contraceptive Choice and Decision-making Among Adolescent and Young Adults Living With Chronic Illness and Medical Complexity: a Focus on Long Acting Reversible Contraception (LARC)
Clinical Trials .Gov Identifier: NAInvestigator: Claudia Borzutzky, MD & Ellen Iverson, MPH

Infant Development
Home intervention for reducing sugary drinks and obesity in Hispanic women-infants.
Clinical Trials .Gov Identifier: NCT03141346Investigator: Michael I Goran, PhD

Mother’s Milk: Determining the Impact of Human Milk Oligosaccharides (HMOs) on Healthy Infant Growth and Development.
Clinical Trials .Gov Identifier: NCT04434027Investigator: Michael I Goran, PhD

Using movement to measure early brain development
Clinical Trials .Gov Identifier: NAInvestigator: Beth Smith, PT, DPT, PhD

Infant MRI / Alzheimer's
Effects of Genetic and Gestational Risk Factors for Late Onset Alzheimer's Disease on the Neonatal Brain Morphology
Clinical Trials .Gov Identifier: NAInvestigator: Natasha Lepore, PHD

Influenza virus (ID)
Influenza vaccinations during breastfeeding: Analysis of immunological and virological responses in breast milk and among breastfed infants.
Clinical Trials .Gov Identifier: NAInvestigator: Pia Pannaraj, MD, MPH

Medical education
Use of 2D and 3D Video on Quality Improvement of Laparoscopic Skills Training
Clinical Trials .Gov Identifier: NAInvestigator: Paul Kokorowski, MD, MPH

NAFLD
Super HEROES: Searching How the Extract Rebaudiosode Occludes Excess Steatosis
Clinical Trials .Gov Identifier: NCT03985020Investigator: Tania Mitsinikos, MD

Nephrotic Syndrome
Cure Glomerulonephropathy
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Kevin Lemley

Nephrotic Syndrome Study Network
Clinical Trials .Gov Identifier: NCT01209000Investigator: Dr. Kevin Lemley

Obesity
An Addiction Model Based Mobile Health Weight Loss Intervention With Coaching in Adolescents With Overweight and Obesity: Multi-Site Randomized Controlled Trial
Clinical Trials .Gov Identifier: NCT03500835Investigator: Alaina Vidmar, MD

Diets Based on PNPLA3 Genotype for Reducing Liver Fat in Hispanics with Pediatric non-alcoholic fatty liver disease
Clinical Trials .Gov Identifier: NCT02948647Investigator: Michael I Goran, PhD

Neuroimaging: Emotions and Appetite Testing Study
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Mimi Kim

Time Limited Eating in Adolescents (Time LEAd): a Pilot Study
Clinical Trials .Gov Identifier: NCT03954223Investigator: Alaina Vidmar, MD

Oncology
CHLA Tumor Registry
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Shahab Asgharzadeh

Pain / Anxiety
Robots using empathy to reduce pain associated with IV insertion
Clinical Trials .Gov Identifier: NCT02840942Investigator: Dr. Margaret Trost

Pain Management
Adolescent Postoperative Longitudinal Study (APOLO)
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Lorraine Kelley-Quon

PFIC
MRX-502: Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects with Progressive Familial Intrahepatic Cholestasis (PFIC) – MARCH-PFIC
Clinical Trials .Gov Identifier: NCT03905330Investigator: Chuan-Hao Lin, MD

MRX-502: Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects with Progressive Familial Intrahepatic Cholestasis (PFIC) – MARCH-PFIC
Clinical Trials .Gov Identifier: NCT03905330Investigator: Chuan-Hao Lin, MD

Prader-Willi-Syndrome (PWS)
Phase 3, Randomized, Double-Blind, Placebo-Controlled, 8-week Clinical Study to Assess the Efficacy, Safety, and Tolerability, of Intranasal Carbetocin (LV-101) in Prader-Willi Syndrome (PWS) with Long Term Follow-Up: CARE-PWS
Clinical Trials .Gov Identifier: NCT03649477Investigator: Alaina Vidmar, MD

Premature Infants (Pre-term)
Predicting the early childhood outcomes of preterm brain shape abnormalities
Clinical Trials .Gov Identifier: NCT03410810Investigator: Dr. Natasha Lepore

Primary Immune Deficiency Disorders (PIDD)
A Phase 3, Multinational, Multicenter, Open-Label Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10% in Adults and Children with Primary Immunodeficiency Diseases
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Joseph Church

Relapsed Acute Lymphoblastic Leukemia (ALL)
T2012-002: A Pilot Study of Vincristine Sulfate Liposome Injection (Marqibo®) in Combination with UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults with Relapse of Acute Lymphoblastic Leukemia
Clinical Trials .Gov Identifier: NCT02879643Investigator: Dr. Alan Wayne

Relapsed Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkins Lymphoma (NHL)
T2014-001: A Phase I Trial of Temsirolimus (CCI-779, Pfizer, Inc.) in Combination with Etoposide and Cyclophosphamide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
Clinical Trials .Gov Identifier: NCT01614197Investigator: Dr. Paul S. Gaynon

Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
20140106 (formerly CFZ008); Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia
Clinical Trials .Gov Identifier: NCT02303821Investigator: Paul S. Gaynon, MD

Relapsed or Refractory Acute Myelogenous Leukemia  (AML)
T2016-003: Epigenetic Reprogramming in Relapse AML: A Phase 1 Study of Decitabine and Vorinostat Followed by Fludarabine, Cytarabine and G-CSF (FLAG) in Children and Young Adults with Relapsed/Refractory AML
Clinical Trials .Gov Identifier: NCT03263936Investigator: Dr. Deepa Bhojwani

Sepsis/ Emergency Medicine
PRagMatic Pediatric Trial of Balanced vs. normal Saline Fluid in Sepsis
Clinical Trials .Gov Identifier: NCT04102371Investigator: Ara Festekjian, MD, MS

Sickle Cell Anemia
Brain blood flow and its response to changes to inhaled oxygen levels in subjects with and without sickle cell disease
Clinical Trials .Gov Identifier: NAInvestigator: Dr. John C. Wood

Systemic Lupus Erythematosus (SLE)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

TBI - Traumatic Brain Injuries
Head Acceleration and Concussion Study
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

Transgender/Gender Diverse
A Longitudinal Study of Gender Nonconformity in Prepubescent Children
Clinical Trials .Gov Identifier: NAInvestigator: Marco Hidalgo, PhD

Transgender/Gender Non-conforming
Maturation, Infectibility, and Trauma Contributes to HIV Susceptibility in Adolescents
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Johanna Olson-Kennedy

Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Bradley Peterson

The Impact of Early Medical Treatment in Transgender Youth
Clinical Trials .Gov Identifier: NAInvestigator: Dr. Johanna Olson-Kennedy

Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN)
Intravenous Remodulin (Treprostinil) as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Randomized, Placebo-Controlled, Safety and Efficacy Study
Clinical Trials .Gov Identifier: NCT02261883Investigator: Philippe Friedlich

Type 1 Diabetes (T1D)
A Prospective, Randomized, Double-Blind Comparison of LY900014 to Humalog with and Open-Label Postprandial LY900014 Treatment Group in Children and Adolescents with Type 1 Diabetes
Clinical Trials .Gov Identifier: NCT03740919Investigator: Roshanak Monzavi, MD

CoYoT1 to California
Clinical Trials .Gov Identifier: NCT03793673Investigator: Jennifer Raymond, MD, MCR

CTLA-4 Ig (Abatacept) for Prevention of Abnormal Glucose Tolerance (AGT) and Diabetes in Relatives At-Risk for Type 1 Diabetes Mellitus (T1DM)
Clinical Trials .Gov Identifier: NCT01773707Investigator: Roshanak Monzavi, MD

Hybrid Closed Loop Insulin Delivery System Data Collection
Clinical Trials .Gov Identifier: NAInvestigator: Roshanak Monzavi, MD

Hydroxychloroquine for Prevention of Abnormal Glucose Tolerance and Diabetes in Individuals At-Risk for Type 1 Diabetes Mellitus
Clinical Trials .Gov Identifier: NCT03428945Investigator: Roshanak Monzavi, MD

Pathway to Prevention
Clinical Trials .Gov Identifier: NCT00097292Investigator: Roshanak Monzavi, MD

Team Clinic - Virtual Expansion of an innovative, muli-disciplinary care model for middle school and high school age adolescents with Type 1 diabetes
Clinical Trials .Gov Identifier: NCT04190368Investigator: Jennifer Raymond, MD, MCR

Type 2 Diabetes
This study is a long-term post-intervention follow-up study of former TODAY subjects
Clinical Trials .Gov Identifier: NAInvestigator: Mitchell Geffner, MD

Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children with Ulcerative Colitis
Clinical Trials .Gov Identifier: NCT02291523Investigator: Sonia Michail, MD

Weight Management
Group Telehealth Weight Management Pilot
Clinical Trials .Gov Identifier: NCT03508622Investigator: Claudia Borzutzky, MD

X-linked Hypophosphatemia
X-linked Hypophosphatemia Disease Monitoring Program – (XLH-DMP)
Clinical Trials .Gov Identifier: NCT03651505Investigator: Anna Ryabets-Lienhard, DO