| Acute Lymphoblastic Leukemia (ALL) |
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| Acute Lymphoblastic Leukemia (ALL) (CAR T ALL) |
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| Acute Lymphoblastic Leukemia (ALL) (Newly Diagnosed ALL) |
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| ADHD-Attention Deficit Hyperactivity Disorder |
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| Anxiety |
| A Sequential Multiple Assignment Randomized Trial (SMART) Assessing Medication and CBT Sequencing Strategies in the Treatment of Predominantly Ethnic Minority, Underserved Youth with Anxiety Disorders |
| Clinical Trials .Gov Identifier: NCT04760275 | Investigator: Bradley Peterson, MD |
|
| Autistic Disorder, Constipation, Gastrointestinal Disease |
| The Met Signaling System, Autism and Gastrointestinal Dysfunction |
| Clinical Trials .Gov Identifier: NCT02442115 | Investigator: Dr. Levitt |
|
| Brain Development |
| MR Imaging Perinatal Brain Injury: Fetal Substudy |
| Investigator: Dr. Jodie Votava-Smith |
|
| Brain Tumor |
| Treatment-related CNS Injury and Cerebral Blood Flow in Children with Posterior Fossa Brain Tumors |
| Investigator: Mary Baron Nelson |
|
| CAH |
| A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase Deficiency |
| Clinical Trials .Gov Identifier: NCT03548246 | Investigator: Mitchell Geffner, MD |
|
| A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment |
| Clinical Trials .Gov Identifier: NCT04490915 | Investigator: Mimi Kim, MD |
|
| Effects of Androgen Excess on Lipid Distribution in Congenital Adrenal Hyperplasia |
| Investigator: Mimi Kim, MD |
|
| Cardiology |
| Advanced MR Imaging of Perinatal Brain Injury: Correlation with Neurocognitive Outcome |
| Investigator: Dr. Ashok Panigrahy |
|
| Correlation of Neonatal Brain Imaging and Neurocognitive Assessment (Fetal Sub-study: Congenital Heart Disease patients and Control patients) |
| Investigator: Dr. Jodie Votava-Smith |
|
| Cerebral Palsy |
| Bone deficits and mechanical loading in ambulatory cerebral palsy |
| Investigator: Tishya Wren, PhD |
|
| Chronic Anemia Syndromes (sickle cell disease and thalassemia) |
| Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia |
| Investigator: John Wood, MD |
|
| Congenital heart malformations |
| Prospective, non-randomized, open label clinical study to assess the feasibility of the Bioabsorbable pulmonary valved conduit in subjects undergoing Right Ventricular Outflow Tract (RVOT) reconstruction |
| Clinical Trials .Gov Identifier: NCT03022708 | Investigator: Cynthia Herrington, MD |
|
| COVID (SARS-CoV-2) |
| DIVINCI : Dissection of Influenza Vaccination and Infection for Childhood Immunity |
| Investigator: Dr. Pia Pannaraj |
|
| Household Exposure and Respiratory Virus Transmission and Immunity Study |
| Investigator: Pia Pannaraj, MD |
|
| Crohn's Disease |
| Safety of FMT in maintenance of pediatric Crohn's disease |
| Clinical Trials .Gov Identifier: NCT03194529 | Investigator: Sonia Michail, MD |
|
| Down Syndrome |
| Non-Invasive Screening for Cerebrovascular Disease in Down Syndrome |
| Investigator: Jonathan D. Santoro, MD |
|
| Eczema (AD) |
| A PHASE 2/3 STUDY INVESTIGATING THE PHARMACOKINETICS, SAFETY, AND EFFICACY OF DUPILUMAB IN PATIENTS AGED ≥6 MONTHS TO <6 YEARS WITH SEVERE ATOPIC DERMATITIS |
| Clinical Trials .Gov Identifier: NCT03346434 | Investigator: Peck Ong, MD |
|
| An Open-Label, Pilot Pharmacokinetic Study of INCB018424 Phosphate Cream in Pediatric Subjects With Atopic Dermatitis |
| Investigator: Peck Ong, MD |
|
| Effect of Dupilumab (anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis - ATOPIC DERMATITIS RESEARCH NETWORK PROTOCOL-ADRN 09 |
| Clinical Trials .Gov Identifier: NCT03389893 | Investigator: Peck Ong, MD |
|
| External Ventricular Drainage (EVD) |
| Non-Invasive Validation of an Inegrated Multi-Sensor Platform for Quantitive Monitoring of Intracranial Pressure, Cerebrospinal Fluid Flow, and Ventricular Catheter Patency |
| Investigator: Dr. Gordon J. McComb |
|
| Extubation failure in newborn infants |
| A study of incidence of upper airway obstruction and other risk factors of extubation failure in newborn infants |
| Investigator: Narayan Prabhu Iyer |
|
| GI / Pancreas |
| Pediatric Longitudinal Cohort Study of Chronic Pancreatitis |
| Clinical Trials .Gov Identifier: NCT03081182 | Investigator: Yuhua Zheng, MD |
|
| Glucocorticoid-Induced Osteoporosis (GIOP) |
| A phase 3 randomized, double-blind, placebo-controlled, Parallel-group Study to evaluate the safety and efficacy of Denosumab / Prolia in Pediatric Subjects with Glucocorticoid-Induced Osteoporosis |
| Clinical Trials .Gov Identifier: NCT03164928 | Investigator: Anna Ryabets-Lienhard, DO |
|
| Growth Hormone Deficiency |
| REAL 4: A trial comparing the effect and safety of once-weekly dosing of somapacitan with daily Norditropin® in children with growth hormone deficiency |
| Clinical Trials .Gov Identifier: NCT03811535 | Investigator: Mitchell Geffner, MD |
|
| Healthy Adults Planning to Receive the Ty21a Typhoid Vaccine |
| Impact of the gut microbiome on response to oral typhoid vaccine in healthy adults |
| Investigator: Dr. Pia Pannaraj |
|
| Healthy Controls |
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| Healthy Mothers and their Healthy Infants Needed |
| Characterization of the breast milk, infant oral and gut microbiomes in multiple geographic locations; role in immune development and response to oral rotavirus vaccine |
| Investigator: Dr. Pia Pannaraj |
|
| Healthy Preterm Infants Needed |
| A Phase 2b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants |
| Clinical Trials .Gov Identifier: NCT02878330 | Investigator: Dr. Pia Pannaraj |
|
| Healthy Subjects Needed |
| (Cis-gender/Unrelated Controls) Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| (Healthy Controls) Assessment of Risk Factors for Injury in the Pediatric Athlete |
| Investigator: Dr. Tishya Wren |
|
| (Healthy Controls) Brain blood flow and its response to changes to inhaled oxygen levels in subjects with and without sickle cell disease |
| Investigator: Dr. John C. Wood |
|
| (Healthy Controls) Head Acceleration and Concussion Study |
| Investigator: Dr. Bradley Peterson |
|
| (Healthy Controls) Neuroimaging: Emotions and Appetite Testing Study |
| Investigator: Dr. Mimi Kim |
|
| (Healthy Fetus) Correlation of Neonatal Brain Imaging and Neurocognitive Assessment (Fetal Sub-study: Congenital Heart Disease patients and Control patients) |
| Investigator: Dr. Jodie Votava-Smith |
|
| (Healthy Pregnancy) Characterizing placental function in utero using MR imaging |
| Investigator: Dr. Vidya Rajagopalan |
|
| (Healthy Volunteers) Precision Medicine: All of Us Research Program |
| Clinical Trials .Gov Identifier: Please visit this website to learn more about the study: https://allofus.nih.gov/ | Investigator: Daniella Meeker, PhD - USC Department of Preventive Medicine |
|
| Healthy Subjects Needed (Healthy Pregnancy) |
| The Sweet PEA Study: a pilot study of the impact of diet during pregnancy on maternal and infant metabolic health |
| Clinical Trials .Gov Identifier: NCT04674033 | Investigator: Michael I Goran, PhD |
|
| Hepatitis B |
| A Randomized, Double-Blind Evaluation of the Pharmacokinetics, Safety, and Antiviral Efficacy of Tenofovir Alafenamide (TAF) in Adolescents with Chronic Hepatitis B Virus Infection (GS-US-320-1092) |
| Clinical Trials .Gov Identifier: NCT02932150 | Investigator: Chuan-Hao Lin, MD |
|
| Hydrocephalus |
| Novel Biomarker Investigation for Patients Undergong CSF Shunt Infection Treatment |
| Investigator: Dr. Tamara Simon |
|
| Hypoplastic Left Heart Syndrome |
| Phase I safety of autologous umbilical cord blood derived mononuclear cells during surgical Stage II palliation of Hypoplastic Left Heart Syndrome |
| Investigator: Ram Kumar Subramanyan, MD |
|
| hypoxic-ischemic encephalopathy (HIE) |
| HIGH DOSE ERYTHROPOIETIN FOR ASPHYXIA AND ENCEPHALOPATHY A randomized, placebo-controlled, double-masked 500 - subject clinical trial of erythropoietin for the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) |
| Clinical Trials .Gov Identifier: NCT02811263 | Investigator: Tai-Wei Wu |
|
| IBD |
| A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of Humira® (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn's Disease (CD) |
| Investigator: Hillel Naon, M.D |
|
| ImproveCareNow |
| Investigator: Hillel Naon, M.D |
|
| Infant Development |
| Home intervention for reducing sugary drinks and obesity in Hispanic women-infants. |
| Clinical Trials .Gov Identifier: NCT03141346 | Investigator: Michael I Goran, PhD |
|
| Mother’s Milk: Determining the Impact of Human Milk Oligosaccharides (HMOs) on Healthy Infant Growth and Development. |
| Clinical Trials .Gov Identifier: NCT04434027 | Investigator: Michael I Goran, PhD |
|
| Research Network on Stress and Health |
| Investigator: Dr. Levitt |
|
| Using movement to measure early brain development |
| Investigator: Beth Smith, PT, DPT, PhD |
|
| Infant MRI / Alzheimer's |
| Effects of Genetic and Gestational Risk Factors for Late Onset Alzheimer's Disease on the Neonatal Brain Morphology |
| Investigator: Natasha Lepore, PHD |
|
| Influenza virus (ID) |
| Influenza vaccinations during breastfeeding: Analysis of immunological and virological responses in breast milk and among breastfed infants. |
| Investigator: Pia Pannaraj, MD, MPH |
|
| Medical education |
| Use of 2D and 3D Video on Quality Improvement of Laparoscopic Skills Training |
| Clinical Trials .Gov Identifier: n/a | Investigator: Paul Kokorowski, MD, MPH |
|
| NAFLD |
| Super HEROES: Searching How the Extract Rebaudiosode Occludes Excess Steatosis |
| Clinical Trials .Gov Identifier: NCT03985020 | Investigator: Tania Mitsinikos, MD |
|
| Nephrotic Syndrome |
| Cure Glomerulonephropathy |
| Investigator: Dr. Kevin Lemley |
|
| Nephrotic Syndrome Study Network |
| Clinical Trials .Gov Identifier: NCT01209000 | Investigator: Dr. Kevin Lemley |
|
| Obesity |
| An Addiction Model Based Mobile Health Weight Loss Intervention With Coaching in Adolescents With Overweight and Obesity: Multi-Site Randomized Controlled Trial |
| Clinical Trials .Gov Identifier: NCT03500835 | Investigator: Alaina Vidmar, MD |
|
| Diets Based on PNPLA3 Genotype for Reducing Liver Fat in Hispanics with Pediatric non-alcoholic fatty liver disease |
| Clinical Trials .Gov Identifier: NCT02948647 | Investigator: Michael I Goran, PhD |
|
| Neuroimaging: Emotions and Appetite Testing Study |
| Investigator: Dr. Mimi Kim |
|
| Time Limited Eating in Adolescents (Time LEAd): a Pilot Study |
| Clinical Trials .Gov Identifier: NCT03954223 | Investigator: Alaina Vidmar, MD |
|
| Oncology |
| CHLA Tumor Registry |
| Investigator: Dr. Shahab Asgharzadeh |
|
| Pain / Anxiety |
| Robots using empathy to reduce pain associated with IV insertion |
| Clinical Trials .Gov Identifier: NCT02840942 | Investigator: Dr. Margaret Trost |
|
| Pain Management |
| Adolescent Postoperative Longitudinal Study (APOLO) |
| Investigator: Dr. Lorraine Kelley-Quon |
|
| PFIC |
| MRX-502: Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects with Progressive Familial Intrahepatic Cholestasis (PFIC) – MARCH-PFIC |
| Clinical Trials .Gov Identifier: NCT03905330 | Investigator: Chuan-Hao Lin, MD |
|
| MRX-502: Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects with Progressive Familial Intrahepatic Cholestasis (PFIC) – MARCH-PFIC |
| Clinical Trials .Gov Identifier: NCT03905330 | Investigator: Chuan-Hao Lin, MD |
|
| Prader-Willi-Syndrome (PWS) |
| Phase 3, Randomized, Double-Blind, Placebo-Controlled, 8-week Clinical Study to Assess the Efficacy, Safety, and Tolerability, of Intranasal Carbetocin (LV-101) in Prader-Willi Syndrome (PWS) with Long Term Follow-Up: CARE-PWS |
| Clinical Trials .Gov Identifier: NCT03649477 | Investigator: Alaina Vidmar, MD |
|
| Premature Infants (Pre-term) |
| Predicting the early childhood outcomes of preterm brain shape abnormalities |
| Clinical Trials .Gov Identifier: NCT03410810 | Investigator: Dr. Natasha Lepore |
|
| Primary Immune Deficiency Disorders (PIDD) |
| A Phase 3, Multinational, Multicenter, Open-Label Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10% in Adults and Children with Primary Immunodeficiency Diseases |
| Investigator: Dr. Joseph Church |
|
| Relapsed Acute Lymphoblastic Leukemia (ALL) |
| T2012-002: A Pilot Study of Vincristine Sulfate Liposome Injection (Marqibo®) in Combination with UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults with Relapse of Acute Lymphoblastic Leukemia |
| Clinical Trials .Gov Identifier: NCT02879643 | Investigator: Dr. Alan Wayne |
|
| Relapsed Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkins Lymphoma (NHL) |
| T2014-001: A Phase I Trial of Temsirolimus (CCI-779, Pfizer, Inc.) in Combination with Etoposide and Cyclophosphamide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma |
| Clinical Trials .Gov Identifier: NCT01614197 | Investigator: Dr. Paul S. Gaynon |
|
| Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) |
| 20140106 (formerly CFZ008); Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia |
| Clinical Trials .Gov Identifier: NCT02303821 | Investigator: Paul S. Gaynon, MD |
|
| Relapsed or Refractory Acute Myelogenous Leukemia (AML) |
| T2016-003: Epigenetic Reprogramming in Relapse AML: A Phase 1 Study of Decitabine and Vorinostat Followed by Fludarabine, Cytarabine and G-CSF (FLAG) in Children and Young Adults with Relapsed/Refractory AML |
| Clinical Trials .Gov Identifier: NCT03263936 | Investigator: Dr. Deepa Bhojwani |
|
| Sepsis/ Emergency Medicine |
| PRagMatic Pediatric Trial of Balanced vs. normal Saline Fluid in Sepsis |
| Clinical Trials .Gov Identifier: NCT04102371 | Investigator: Ara Festekjian, MD, MS |
|
| Sickle Cell Anemia |
| Brain blood flow and its response to changes to inhaled oxygen levels in subjects with and without sickle cell disease |
| Investigator: Dr. John C. Wood |
|
| Systemic Lupus Erythematosus (SLE) |
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| TBI - Traumatic Brain Injuries |
| Head Acceleration and Concussion Study |
| Investigator: Dr. Bradley Peterson |
|
| Transgender/Gender Non-conforming |
| Maturation, Infectibility, and Trauma Contributes to HIV Susceptibility in Adolescents |
| Investigator: Dr. Johanna Olson-Kennedy |
|
| Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior |
| Investigator: Dr. Bradley Peterson |
|
| The Impact of Early Medical Treatment in Transgender Youth |
| Investigator: Dr. Johanna Olson-Kennedy |
|
| Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN) |
| Intravenous Remodulin (Treprostinil) as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Randomized, Placebo-Controlled, Safety and Efficacy Study |
| Clinical Trials .Gov Identifier: NCT02261883 | Investigator: Philippe Friedlich |
|
| Type 1 Diabetes (T1D) |
| A Prospective, Randomized, Double-Blind Comparison of LY900014 to Humalog with and Open-Label Postprandial LY900014 Treatment Group in Children and Adolescents with Type 1 Diabetes |
| Clinical Trials .Gov Identifier: NCT03740919 | Investigator: Roshanak Monzavi, MD |
|
| CoYoT1 to California |
| Clinical Trials .Gov Identifier: NCT03793673 | Investigator: Jennifer Raymond, MD, MCR |
|
| CTLA-4 Ig (Abatacept) for Prevention of Abnormal Glucose Tolerance (AGT) and Diabetes in Relatives At-Risk for Type 1 Diabetes Mellitus (T1DM) |
| Clinical Trials .Gov Identifier: NCT01773707 | Investigator: Roshanak Monzavi, MD |
|
| Hybrid Closed Loop Insulin Delivery System Data Collection |
| Investigator: Roshanak Monzavi, MD |
|
| Hydroxychloroquine for Prevention of Abnormal Glucose Tolerance and Diabetes in Individuals At-Risk for Type 1 Diabetes Mellitus |
| Clinical Trials .Gov Identifier: NCT03428945 | Investigator: Roshanak Monzavi, MD |
|
| Pathway to Prevention |
| Clinical Trials .Gov Identifier: NCT00097292 | Investigator: Roshanak Monzavi, MD |
|
| Team Clinic - Virtual Expansion of an innovative, muli-disciplinary care model for middle school and high school age adolescents with Type 1 diabetes |
| Clinical Trials .Gov Identifier: NCT04190368 | Investigator: Jennifer Raymond, MD, MCR |
|
| Type 2 Diabetes |
| This study is a long-term post-intervention follow-up study of former TODAY subjects |
| Investigator: Mitchell Geffner, MD |
|
| Ulcerative Colitis |
| The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children with Ulcerative Colitis |
| Clinical Trials .Gov Identifier: NCT02291523 | Investigator: Sonia Michail, MD |
|
| Weight Management |
| Group Telehealth Weight Management Pilot |
| Clinical Trials .Gov Identifier: NCT03508622 | Investigator: Claudia Borzutzky, MD |
|
| X-linked Hypophosphatemia |
| X-linked Hypophosphatemia Disease Monitoring Program – (XLH-DMP) |
| Clinical Trials .Gov Identifier: NCT03651505 | Investigator: Anna Ryabets-Lienhard, DO |
|
