CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Acute Lymphoblastic Leukemia (ALL)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

Acute Lymphoblastic Leukemia (ALL) (CAR T ALL)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

Acute Lymphoblastic Leukemia (ALL) (Newly Diagnosed ALL)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

ADHD-Attention Deficit Hyperactivity Disorder
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

Autistic Disorder, Constipation, Gastrointestinal Disease
The Met Signaling System, Autism and Gastrointestinal Dysfunction
Clinical Trials .Gov Identifier: NCT02442115Investigator: Dr. Levitt

Brain Development
MR Imaging Perinatal Brain Injury: Fetal Substudy
Investigator: Lisa Paquette, MD

Brain Tumor
Treatment-related CNS Injury and Cerebral Blood Flow in Children with Posterior Fossa Brain Tumors
Investigator: Mary Baron Nelson

Cardiology
Advanced MR Imaging of Perinatal Brain Injury: Correlation with Neurocognitive Outcome
Investigator: Dr. Ashok Panigrahy

Correlation of Neonatal Brain Imaging and Neurocognitive Assessment (Fetal Sub-study: Congenital Heart Disease patients and Control patients)
Investigator: Dr. Lisa Paquette

Cerebral Palsy
Bone deficits and mechanical loading in ambulatory cerebral palsy
Investigator: Tishya Wren, PhD

Chronic Anemia Syndromes (sickle cell disease and thalassemia)
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia
Investigator: John Wood, MD

Congenital heart malformations
Prospective, non-randomized, open label clinical study to assess the feasibility of the Bioabsorbable pulmonary valved conduit in subjects undergoing Right Ventricular Outflow Tract (RVOT) reconstruction
Clinical Trials .Gov Identifier: NCT03022708Investigator: Cynthia Herrington, MD

Crohn's Disease
Safety of FMT in maintenance of pediatric Crohn's diase
Clinical Trials .Gov Identifier: NCT03194529Investigator: Sonia Michail, MD

Eczema (AD)
A PHASE 2/3 STUDY INVESTIGATING THE PHARMACOKINETICS, SAFETY, AND EFFICACY OF DUPILUMAB IN PATIENTS AGED ≥6 MONTHS TO <6 YEARS WITH SEVERE ATOPIC DERMATITIS
Clinical Trials .Gov Identifier: NCT03346434Investigator: Peck Ong, MD

Effect of Dupilumab (anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis - ATOPIC DERMATITIS RESEARCH NETWORK PROTOCOL-ADRN 09
Clinical Trials .Gov Identifier: NCT03389893Investigator: Peck Ong, MD

External Ventricular Drainage (EVD)
Non-Invasive Validation of an Inegrated Multi-Sensor Platform for Quantitive Monitoring of Intracranial Pressure, Cerebrospinal Fluid Flow, and Ventricular Catheter Patency
Investigator: Dr. Gordon J. McComb

Extubation failure in newborn infants
A study of incidence of upper airway obstruction and other risk factors of extubation failure in newborn infants
Investigator: Narayan Prabhu Iyer

GI / Pancreas
Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
Clinical Trials .Gov Identifier: NCT03081182Investigator: Yuhua Zheng, MD

Glucocorticoid-Induced Osteoporosis (GIOP)
A phase 3 randomized, double-blind, placebo-controlled, Parallel-group Study to evaluate the safety and efficacy of Denosumab / Prolia in Pediatric Subjects with Glucocorticoid-Induced Osteoporosis
Clinical Trials .Gov Identifier: NCT03164928Investigator: Anna Ryabets-Lienhard, DO

Healthy Adults Planning to Receive the Ty21a Typhoid Vaccine
Impact of the gut microbiome on response to oral typhoid vaccine in healthy adults
Investigator: Dr. Pia Pannaraj

Healthy Controls
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

Healthy Mothers and their Healthy Infants Needed
Characterization of the breast milk, infant oral and gut microbiomes in multiple geographic locations; role in immune development and response to oral rotavirus vaccine
Investigator: Dr. Pia Pannaraj

Healthy Preterm Infants Needed
A Phase 2b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants
Clinical Trials .Gov Identifier: NCT02878330Investigator: Dr. Pia Pannaraj

Healthy Subjects Needed
(Cis-gender/Unrelated Controls) Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

(Healthy Controls) Assessment of Risk Factors for Injury in the Pediatric Athlete
Investigator: Dr. Tishya Wren

(Healthy Controls) Brain blood flow and its response to changes to inhaled oxygen levels in subjects with and without sickle cell disease
Investigator: Dr. John C. Wood

(Healthy Controls) Head Acceleration and Concussion Study
Investigator: Dr. Bradley Peterson

(Healthy Controls) Infant and Toddler Short Gut Feeding Outcomes Study
Investigator: Dr. Russell Merritt

(Healthy Controls) Neuroimaging: Emotions and Appetite Testing Study
Investigator: Dr. Mimi Kim

(Healthy Fetus) Correlation of Neonatal Brain Imaging and Neurocognitive Assessment (Fetal Sub-study: Congenital Heart Disease patients and Control patients)
Investigator: Dr. Lisa Paquette

(Healthy Pregnancy) Characterizing placental function in utero using MR imaging
Investigator: Dr. Vidya Rajagopalan

(Healthy Volunteers) Precision Medicine: All of Us Research Program
Clinical Trials .Gov Identifier: Please visit this website to learn more about the study: https://allofus.nih.gov/Investigator: Daniella Meeker, PhD - USC Department of Preventive Medicine

Healthy Subjects Needed (Healthy Pregnancy)
The Sweet PEA Study: a pilot study of the impact of diet during pregnancy on maternal and infant metabolic health
Investigator: Michael I Goran, PhD

Hypoplastic Left Heart Syndrome
Phase I safety of autologous umbilical cord blood derived mononuclear cells during surgical Stage II palliation of Hypoplastic Left Heart Syndrome
Investigator: Ram Kumar Subramanyan, MD

hypoxic-­ischemic encephalopathy (HIE)
HIGH DOSE ERYTHROPOIETIN FOR ASPHYXIA AND ENCEPHALOPATHY A randomized, placebo-­controlled, double-­masked 500 -­ subject clinical trial of erythropoietin for the treatment of neonatal hypoxic-­ischemic encephalopathy (HIE)
Clinical Trials .Gov Identifier: NCT02811263Investigator: Tai-Wei Wu

IBD
A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of Humira® (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn's Disease (CD)
Investigator: Hillel Naon, M.D

An Inflammatory Bowel Disease Multicenter, Prospective, Long-term Registry of Pediatric Patients
Investigator: Hillel Naon, M.D

ImproveCareNow
Investigator: Hillel Naon, M.D

Infant Development
Home intervention for reducing sugary drinks and obesity in Hispanic women-infants.
Clinical Trials .Gov Identifier: NCT03141346Investigator: Michael I Goran, PhD

Mother’s Milk: Determining the Impact of Human Milk Oligosaccharides (HMOs) on Healthy Infant Growth and Development.
Investigator: Michael I Goran, PhD

Research Network on Stress and Health
Investigator: Dr. Levitt

Influenza virus (ID)
Influenza vaccinations during breastfeeding: Analysis of immunological and virological responses in breast milk and among breastfed infants.
Investigator: Pia Pannaraj, MD, MPH

Nephrotic Syndrome
Cure Glomerulonephropathy
Investigator: Dr. Kevin Lemley

Nephrotic Syndrome Study Network
Clinical Trials .Gov Identifier: NCT01209000Investigator: Dr. Kevin Lemley

Obesity
An Addiction Model Based Mobile Health Weight Loss Intervention With Coaching in Adolescents With Overweight and Obesity: Multi-Site Randomized Controlled Trial
Clinical Trials .Gov Identifier: NCT03500835Investigator: Alaina Vidmar, MD

Diets Based on PNPLA3 Genotype for Reducing Liver Fat in Hispanics with Pediatric non-alcoholic fatty liver disease
Clinical Trials .Gov Identifier: NCT02948647Investigator: Michael I Goran, PhD

Neuroimaging: Emotions and Appetite Testing Study
Investigator: Dr. Mimi Kim

Oncology
CHLA Tumor Registry
Investigator: Dr. Shahab Asgharzadeh

Pain / Anxiety
Robots using empathy to reduce pain associated with IV insertion
Clinical Trials .Gov Identifier: NCT02840942Investigator: Dr. Margaret Trost

Pain Management
Adolescent Postoperative Longitudinal Study (APOLO)
Investigator: Dr. Lorraine Kelley-Quon

Postpartum Depression Symptoms
The Impact of a Mother-Baby Group on Depression and Infant Development in Mothers with Postpartum Depression and Their Infants
Investigator: Aviril Sepulveda, OTD

Prader-Willi-Syndrome (PWS)
Phase 3, Randomized, Double-Blind, Placebo-Controlled, 8-week Clinical Study to Assess the Efficacy, Safety, and Tolerability, of Intranasal Carbetocin (LV-101) in Prader-Willi Syndrome (PWS) with Long Term Follow-Up: CARE-PWS
Clinical Trials .Gov Identifier: NCT03649477Investigator: Alaina Vidmar, MD

Premature Infants (Pre-term)
Predicting the early childhood outcomes of preterm brain shape abnormalities
Clinical Trials .Gov Identifier: NCT03410810Investigator: Dr. Natasha Lepore

Primary Immune Deficiency Disorders (PIDD)
A Phase 3, Multinational, Multicenter, Open-Label Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10% in Adults and Children with Primary Immunodeficiency Diseases
Investigator: Dr. Joseph Church

Relapsed Acute Lymphoblastic Leukemia (ALL)
T2012-002: A Pilot Study of Vincristine Sulfate Liposome Injection (Marqibo®) in Combination with UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults with Relapse of Acute Lymphoblastic Leukemia
Clinical Trials .Gov Identifier: NCT02879643Investigator: Dr. Alan Wayne

Relapsed Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkins Lymphoma (NHL)
T2014-001: A Phase I Trial of Temsirolimus (CCI-779, Pfizer, Inc.) in Combination with Etoposide and Cyclophosphamide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
Clinical Trials .Gov Identifier: NCT01614197Investigator: Dr. Paul S. Gaynon

Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
20140106 (formerly CFZ008); Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia
Clinical Trials .Gov Identifier: NCT02303821Investigator: Paul S. Gaynon, MD

Relapsed or Refractory Acute Myelogenous Leukemia  (AML)
T2016-003: Epigenetic Reprogramming in Relapse AML: A Phase 1 Study of Decitabine and Vorinostat Followed by Fludarabine, Cytarabine and G-CSF (FLAG) in Children and Young Adults with Relapsed/Refractory AML
Clinical Trials .Gov Identifier: NCT03263936Investigator: Dr. Deepa Bhojwani

Sickle Cell Anemia
Brain blood flow and its response to changes to inhaled oxygen levels in subjects with and without sickle cell disease
Investigator: Dr. John C. Wood

Systemic Lupus Erythematosus (SLE)
Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

TBI - Traumatic Brain Injuries
Head Acceleration and Concussion Study
Investigator: Dr. Bradley Peterson

Transgender/Gender Non-conforming
Maturation, Infectibility, and Trauma Contributes to HIV Susceptibility in Adolescents
Investigator: Dr. Johanna Olson-Kennedy

Mental Health and Medical Illness Effects on Brain, Cognition, and Behavior
Investigator: Dr. Bradley Peterson

The Impact of Early Medical Treatment in Transgender Youth
Investigator: Dr. Johanna Olson-Kennedy

Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN)
Intravenous Remodulin (Treprostinil) as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Randomized, Placebo-Controlled, Safety and Efficacy Study
Clinical Trials .Gov Identifier: NCT02261883Investigator: Philippe Friedlich

Type 1 Diabetes (T1D)
Adolescents and Young Adults with T1D Assessment in the Center for Endocrinology, Diabetes, and Metabolism
Investigator: Dr. Jennifer Raymond

CoYoT1 to California
Clinical Trials .Gov Identifier: NCT03793673Investigator: Jennifer Raymond, MD, MCR

CTLA-4 Ig (Abatacept) for Prevention of Abnormal Glucose Tolerance (AGT) and Diabetes in Relatives At-Risk for Type 1 Diabetes Mellitus (T1DM)
Clinical Trials .Gov Identifier: NCT01773707Investigator: Roshanak Monzavi, MD

Family Communication about Type 1 Diabetes
Investigator: Jennifer Raymond, MD

Hybrid Closed Loop Insulin Delivery System Data Collection
Investigator: Roshanak Monzavi, MD

Hydroxychloroquine for Prevention of Abnormal Glucose Tolerance and Diabetes in Individuals At-Risk for Type 1 Diabetes Mellitus
Clinical Trials .Gov Identifier: NCT03428945Investigator: Roshanak Monzavi, MD

Pathway to Prevention
Clinical Trials .Gov Identifier: NCT00097292Investigator: Roshanak Monzavi, MD

Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children with Ulcerative Colitis
Clinical Trials .Gov Identifier: NCT02291523Investigator: Sonia Michail, MD

X-linked Hypophosphatemia
X-linked Hypophosphatemia Disease Monitoring Program – (XLH-DMP)
Clinical Trials .Gov Identifier: NCT03651505Investigator: Anna Ryabets-Lienhard, DO