Research Blog

Published on April 6, 2016
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Children’s Hospital Los Angeles to Initiate Clinical Trial for Kids with Treatment-Resistant LeukemiaResearchers at Children’s Hospital Los Angeles will be testing a new therapy for acute lymphoblastic leukemia using specially engineered T-cells isolated from patients that can... Read More
Published on April 4, 2016
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In a new editorial published in JAMA Pediatrics, Johanna Olson-Kennedy, MD, medical director of The Center for Transyouth Health and Development at Children’s Hospital Los Angeles discusses disparities in mental health in young transgender populations. A recent study, also... Read More
Published on March 31, 2016
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Here we see the development of the brain-pancreas axis during gestation. According to a new study out of Children’s Hospital Los Angeles, the hormone leptin alters neuronal growth between the brain and pancreas during embryonic development, which may play a role in the onset... Read More
Published on March 29, 2016
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Eczema or atopic dermatitis is a condition where the areas of the skin are inflamed, resulting in symptoms ranging from redness to severe rashes and blisters. The specific causes of eczema remain unknown, though the condition has been linked to other conditions ranging from... Read More
Published on March 24, 2016
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Children’s Hospital Los Angeles Awarded $7.1 Million by CIRM to develop new cellular therapy to treat digestive nerve disordersHirschsprung’s disease, where crucial nerve cells are absent in parts of the gastrointestinal tract resulting in the inability to properly push food... Read More
Published on March 23, 2016
The scientific and healthcare communities have become increasingly aware of the profound impact that early life events have on the lifelong health and well-being of children and the adults they will become. Read More
Published on March 22, 2016
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A new study out of Children’s Hospital Los Angeles has found excessive fat in legs of children with a severe form of spina bifida suggests increased risk for metabolic disordersRepresentative quantified computed tomography (CT) slices showing excess adipose or fatty tissues (... Read More
Published on March 18, 2016
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Despite Increases in Screening, Study Finds Only 44 Percent of Pediatricians Inquire about Maternal DepressionMaternal depression affects up to 40 percent of mothers with young children and can have many negative effects on the infant and developing child including feeding... Read More
Published on March 16, 2016
We are living through a revolution in biology that is giving us a deeper, sharper understanding about how early experience effects development of the brain. Read More
Published on March 14, 2016
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Study suggests macrophage activation as possible reason for differential bone loss in adolescent malesActivation of macrophages – a type of immune cell which, in the bone, takes the form of bone-eating osteoclast cells (above) – may play a significant role in bone loss found in... Read More
Published on March 10, 2016
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Research suggests racism experienced in childhood can lead to health problems later in life.While overall health has improved, from reduced infant mortality to improved outcomes for a variety of diseases, racial and ethnic disparities in health remain a significant problem that... Read More
Published on March 4, 2016
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“When I ask my patients, they tell me ‘no, I don’t smoke’,” says Diane Tanaka, MD, medical director of Adolescent and Young Adult Medicine at Children’s Hospital Los Angeles. “It wasn’t until I saw them with e-cigarettes that I realized that I wasn’t asking the right question.”... Read More
Published on March 2, 2016
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Comparison of radiation exposure in x-ray based photon radiotherapy (left) and proton radiotherapy (right). Image source: Taheri-Kadkhoda et al. Radiation Oncology 2008 3:4 doi:10.1186/1748-717X-3-4, Creative Commons Attribution 2.0 Generic. Medulloblastoma, the most common... Read More
Published on February 29, 2016
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Robert Seeger, MD, division head for Basic and Translational Research of the Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) has been selected for the 2016 Lifetime Achievement Award from the Pediatric Blood and Marrow Transplant Consortium (PBMC... Read More
Published on February 27, 2016
The Flint, Michigan water crisis raises concerns about the effects of lead poisoning on children. According to the World Health Organization, lead poisoning accounts for 0.6% of the global burden of disease. Children are particularly susceptible to the effects of lead poisoning... Read More
Published on February 24, 2016
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In 2006, researchers studying obesity stumbled upon a gene called PID1 (Phosphotyrosine Interaction Domain containing 1). They found the gene played a role in insulin resistance in obese patients, making it a target for development of new treatments for obesity.Three years after... Read More
Published on February 21, 2016
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A once relatively unknown virus has recently made headlines as over 4000 cases of severe birth defects connected to the virus have been reported in Brazil. The Zika virus is related to the dengue and west Nile viruses and has many researchers scrambling to uncover both how the... Read More
Published on February 18, 2016
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Children’s Hospital Los Angeles (CHLA) and Thermo Fisher Scientific have agreed to develop a next-generation sequencing (NGS)-based panel designed specifically for pediatric cancer research.  The assay would be CHLA’s first NGS panel designed to target biomarkers associated with... Read More
Published on February 16, 2016
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Normal lung (image A) compared to lung developed with low levels of VEGF (image B) demonstrating abnormal air spaces and lung tissue. Photo courtesy of Grikscheit Lab, The Saban Research Institute of Children’s Hospital Los AngelesInvestigators at The Saban Research Institute of... Read More
Published on February 14, 2016
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Here we see proliferating cardiomyocytes or heart cells from zebrafish. Zebrafish, a tropical fish in the minnow family commonly used in scientific research, is known best for its regenerative abilities. Researchers at Children’s Hospital Los Angeles led by Ching-Ling Lien, PhD... Read More

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