Research Blog

Published on April 20, 2017
In 1963, the death of baby Patrick Bouvier Kennedy, who was born 5 ½ weeks premature and died from respiratory distress syndrome, gripped the nation.  At that time, medicine had very little to offer premature babies with respiratory distress, but baby Patrick’s death put a... Read More
Published on April 20, 2017
Twenty years ago, a child with inflammatory arthritis had a very different life than a child with that same disease has today. In 1997, that child suffered from chronic pain and lack of mobility that kept them homebound – unable to go to school, have the opportunity to make... Read More
Published on April 18, 2017
“My goal is to decrease childhood blindness by treating pediatric eye disease in an innovative way,” says Bibiana Jin Reiser, MD, MS, director of the Cornea and Glaucoma Institute at CHLA. Using technology developed for adults, she is optimizing it to treat children.“The disease... Read More
Published on April 17, 2017
Research is a team sport. Each advance is incremental – small but crucial in reaching the next, significant step toward finding a solution. Science is currently under a great deal of scrutiny because of how it is conducted and how it is funded.  At Children’s Hospital Los... Read More
Published on April 5, 2017
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Zebrafish heart with prominent coronary vessels (marked by transgenic fluorescent reporters)Heart disease is among the leading causes of death for both adults and children. A heart attack (or myocardial infarction) occurs when the heart is deprived of oxygen due to blockage of a... Read More
Published on March 20, 2017
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Brain scans of chronically depressed patients before and during treatment. Left: Before treatment, depressed patients had a thicker cortex in the frontal, temporal and parietal lobes of the brain (shown in red). Right: Over 10 weeks of medication, these regions (shown in blue)... Read More
Published on March 3, 2017
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In a study led by Barbara Driscoll, PhD, of The Saban Research Institute of Children’s Hospital Los Angeles, researchers demonstrate, for the first time that inhaled resveratrol treatments slow aging-related degenerative changes in mouse lung.  Lung aging, characterized by... Read More
Published on February 8, 2017
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Brain activity of spider phobic people during repeated presentation of pictures of spiders - when they were aware of them (left column), and when they were not aware of them (right column). The phobic people processed t​he spider pictures significantly more when they were not... Read More
Published on January 30, 2017
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Investigators at Children’s Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are... Read More
Published on January 9, 2017
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Characterized by repetition of sounds, syllables, or words; prolongation of sounds; and interruptions in speech, stuttering occurs most often in children between the ages of 2 and 6 as they are developing their language skills. While 75 percent outgrow or recover from stuttering... Read More
Published on January 3, 2017
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Innate immune cells of the myeloid lineage (primarily macrophages and neutrophils) surrounding the epithelial crypts in inflamed colonic tissue. Inflammatory Bowel Disease (IBD) is a debilitating, incurable condition affecting approximately 1.5 million... Read More
Published on December 13, 2016
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Doctors in training, known as medical residents, often find themselves tasked with significant clinical responsibilities while continuing to learn how to be a physician. Many hospitals offer lecture conferences to supplement the education of residents, but turnout to these... Read More
Published on December 6, 2016
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Investigators from Children’s Hospital Los Angeles and 37 other Children’s Oncology Group hospitals in the U.S. and Canada have determined that sodium thiosulfate prevents cisplatin-induced hearing loss in children and adolescents with cancer. Results of this randomized,... Read More
Published on November 29, 2016
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Differences in Neural Density between Stuttering and Control Participants Blue: reduced neural density in stutterers; Red: increased neural density in stutterersResearchers at Children’s Hospital Los Angeles (CHLA) have conducted the first study of its kind, using proton... Read More
Published on November 17, 2016
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Human Native Lung (left) and Tissue Engineered Lung (right)Scientists at Children’s Hospital Los Angeles have developed a tissue-engineered model of lung and trachea which contains the diverse cell types present in the human respiratory tract.  The study, led by principal... Read More
Published on November 4, 2016
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Children with sleep apnea may be at increased risk for overnight respiratory events (ORE) following anesthesia.  But researchers at Children’s Hospital Los Angeles (CHLA) wondered if the practice of hospitalizing a child overnight following sedation for certain non-surgical... Read More
Published on October 27, 2016
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A study by researchers from The Saban Research Institute of Children’s Hospital Los Angeles reveals a promising therapeutic target for improving lung function in infants. Their study, now published online by the American Journal of Physiology-Lung Cellular and Molecular... Read More
Published on October 17, 2016
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Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176 cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD. Researchers at The Saban Research Institute of Children’s Hospital Los Angeles have identified an unsuspected and critical role... Read More
Published on October 12, 2016
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Recently, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his discoveries of mechanisms for a fundamental process called autophagy. Mutations in autophagy genes can cause disease, and disturbances in the autophagic process can lead to diabetes,... Read More
Published on September 30, 2016
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The Food and Drug Administration has approved the first drug to treat patients with Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in childhood. Some experts contend that not enough evidence exists to prove the drug – eteplirsen – is effective, because... Read More

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