Research Blog

Published on January 20, 2016
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In a new article published in Trends in Cognitive Sciences, corresponding author Elizabeth Sowell, PhD of Children’s Hospital Los Angeles, in collaboration with authors from Harvard Medical School and San Diego State University, reviewed ongoing research efforts to determine... Read More
Published on December 30, 2015
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Every year brings more breakthroughs and discoveries in the field of pediatric medicine, many from right here in Children’s Hospital Los Angeles. Today, we’re recapping the top 5 most popular ResearCHLA stories of the year. Stay tuned for many more in the new year!1. Researchers... Read More
Published on December 28, 2015
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Bubbles ‘n BowelsSmall bowel syndrome (SBS), a disorder characterized by malabsorption of nutrients due to removal of parts of the small intestine, affects roughly 9000 children and 3500 adults in the United States annually. Surgical removal of the intestine is often done in... Read More
Published on December 24, 2015
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Either way, we hope your holidays are stimulating!from The Saban Research Institute of Children’s Hospital Los Angeles
Published on December 20, 2015
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Sex-based differences in incidence and long-term outcomes have been well documented in pediatric cancer patients. Investigators at Children’s Hospital Los Angeles have now discovered similar differences in acute side effects due to treatment in pediatric patients with acute... Read More
Published on December 11, 2015
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Purple haze, all in my lungA variety of signaling molecules control the branching program by which the lung grows and develops. In this image we see the beginning of normal branching that occurs at budding points of the lung known as epithelial tips. Researchers at Children’s... Read More
Published on December 4, 2015
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Newborn brain images show total maternal prenatal iron intake (purple) correlates with tissue organization and development. Image courtesy of Bradley Peterson, MD, The Saban Research Institute, Children’s Hospital Los Angeles.In the first study of its kind, researchers have... Read More
Published on December 2, 2015
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Dr. Joe Church, shown with patient Cristina Jade Peña in 1994.  Today, at age 31, Cristina is leading “a wonderful and happy life, because of medical advancements, and the lifesaving care and treatment by Dr. Church and his team at CHLA.”Joseph Church, MD, has a thick stack of... Read More
Published on December 1, 2015
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Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger.  This can make it difficult for an individual with ASD to successfully navigate social... Read More
Published on November 19, 2015
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Birth of a NeuronWhat can the developing brain, specifically the birth of neurons (green), tell us about predisposition to childhood obesity and diabetes? Researchers at Children’s Hospital Los Angeles, led by Sebastien Bouret, PhD, are investigating how neuron development in... Read More
Published on November 9, 2015
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More children are surviving malignant brain tumors than in the past, thanks to intense treatments using platinum-based chemotherapy. Unfortunately, the therapy has a known side effect of permanent hearing loss, resulting from damage to the inner ear. Investigators at Children’s... Read More
Published on November 4, 2015
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Bacterial infections can cause severe medical complications in newborns, such as neonatal meningitis – the inflammation of the protective membranes of the central nervous system.  Exactly how newborns contract these infections however remains unknown. Research conducted at... Read More
Published on October 30, 2015
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Decreased lung development often occurs in babies born prematurely. Known as bronchopulmonary dysplasia, the condition is linked to decreased numbers of specialized lung cells known as lipofibroblasts (LIF). Here, researchers at Children’s Hospital Los Angeles demonstrate how... Read More
Published on October 28, 2015
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Left: Untreated cancer cells. Right: Cells treated with the nanoparticle complex HerMn, which is cytotoxic to tumor cells (disrupting the cytoskeleton and structure of these cells as shown above) while simultaneously enhancing MRI contrast. Image courtesy of Karn Sorasaenee, PhD... Read More
Published on October 15, 2015
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Most babies are leaving their mark on mothers, detectable even after birth, in the form of fetal cells left behind after pregnancy. Image courtesy of Shutterstock.A recent study published in Molecular Human Reproduction reports evidence of fetal cells escaping the womb and... Read More
Published on October 14, 2015
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Researchers use MRS imaging to study effects of hypothermia for infants with decreased oxygen to the brainCHLA’s team of nurses and medical professionals administer hypothermia treatments to newborns to prevent brain damage caused by an inhibited oxygen supply to the brain.... Read More
Published on October 10, 2015
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How natural killer immune cells can fight cancerNatural killer (NK) immune cells can identify infected or potentially cancerous cells in the body and induce cell death. Image courtesy of Shutterstock.Cancer cells present a unique challenge to the immune system in that they are... Read More
Published on October 7, 2015
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Tissue-engineered colon generated from cells from a patient with Hirschsprung’s disease. Nerve cells shown in green. Image courtesy of Grikscheit Laboratory, The Saban Research Institute, CHLA.A study by scientists at Children’s Hospital Los Angeles has shown that tissue-... Read More
Published on October 5, 2015
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Neural dysfunction in cognitive control circuits during adolescence could be predictor of psychotic disordersThose at clinically high risk (CHR) for psychotic disorders on average had lower levels of conflict-related brain activity compared to healthy controls (HC). VS = ventral... Read More
Published on October 1, 2015
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In a new study published in the journal Pediatric Emergency Care, investigators at Children’s Hospital Los Angeles piloted a brief mental health screening tool to be used with patients accessing the emergency department for medical complaints who might be at risk... Read More

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