Research Blog
Published on February 8, 2017
Brain activity of spider phobic people during repeated presentation
of pictures of spiders - when they were aware of them (left column),
and when they were not aware of them (right column). The phobic
people processed the spider pictures significantly more when they were not... Read More
Published on January 30, 2017
Investigators at Children’s Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are... Read More
Published on January 9, 2017
Characterized by repetition of sounds, syllables, or words;
prolongation of sounds; and interruptions in speech, stuttering occurs most often in children between the ages of
2 and 6 as they are developing their language skills. While 75 percent outgrow or recover
from stuttering... Read More
Published on January 3, 2017
Innate immune cells of the myeloid lineage
(primarily macrophages and neutrophils) surrounding the epithelial crypts in
inflamed colonic tissue.
Inflammatory Bowel Disease (IBD) is a debilitating,
incurable condition affecting approximately 1.5 million... Read More
Published on December 13, 2016
Doctors in training, known as medical
residents, often find themselves tasked with significant clinical
responsibilities while continuing to learn how to be a physician. Many
hospitals offer lecture conferences to supplement the education of residents,
but turnout to these... Read More
Published on December 6, 2016
Investigators from Children’s Hospital Los Angeles and 37
other Children’s Oncology Group hospitals in the U.S. and Canada have
determined that sodium thiosulfate prevents cisplatin-induced hearing loss in
children and adolescents with cancer. Results of this randomized,... Read More
Published on November 29, 2016
Differences in
Neural Density between Stuttering and Control Participants Blue: reduced neural density in stutterers; Red: increased neural density in stutterersResearchers at Children’s Hospital
Los Angeles (CHLA) have conducted the first study of its kind, using proton... Read More
Published on November 17, 2016
Human Native Lung (left) and Tissue Engineered Lung (right)Scientists at Children’s Hospital Los Angeles have developed
a tissue-engineered model of lung and trachea which contains the diverse cell
types present in the human respiratory tract.
The study, led by principal... Read More
Published on November 4, 2016
Children with sleep apnea may
be at increased risk for overnight respiratory events (ORE) following
anesthesia. But researchers at
Children’s Hospital Los Angeles (CHLA) wondered if the practice of
hospitalizing a child overnight following sedation for certain non-surgical... Read More
Published on October 27, 2016
A study by researchers from The Saban Research Institute of
Children’s Hospital Los Angeles reveals a promising therapeutic target for
improving lung function in infants.
Their study, now published online
by the American Journal of Physiology-Lung Cellular and Molecular... Read More
Published on October 17, 2016
Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176
cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD.
Researchers at The Saban Research
Institute of Children’s Hospital Los Angeles have identified an unsuspected and
critical role... Read More
Published on October 12, 2016
Recently, Yoshinori
Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his
discoveries of mechanisms for a fundamental process called autophagy. Mutations
in autophagy genes can cause disease, and disturbances in the autophagic
process can lead to diabetes,... Read More
Published on September 30, 2016
The Food and Drug Administration has approved the first drug to treat patients with
Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in
childhood. Some experts contend that not enough evidence exists to prove the
drug – eteplirsen – is effective, because... Read More
Published on September 23, 2016
Military personnel can be exposed to dusts and toxicants in
the field that may contribute to lung disease. The available technologies to
detect early-stage alterations of lung function in patients require a long
processing time and lack satisfactory sensitivity and resolution,... Read More
Published on September 16, 2016
Recent studies have indicated an increased need for preventive
mental health and social services among Filipinos, in part because of higher
rates of problem behaviors such as substance use, high school dropout, and teen
births compared to other Asian subgroups. Filipino... Read More
Published on September 14, 2016
In a first-of-its-kind look at human kidney development,
researchers at The Saban Research Institute of Children’s Hospital Los Angeles
have isolated human nephron progenitor (NP) cells. Their results, published online in the
journal Stem Cell Translational Medicine,
will help... Read More
Published on September 9, 2016
Surface of the mouse colon repaired by stem cells after a flare of
ulcerative colitis. The different colors show the contributions of individual
stem cells as they have multiplied to patch the breaks, or ulcers, in the
colonic surface. These ulcers were originally caused by the... Read More
Published on September 6, 2016
Genetic Intersection of Conditions AnalyzedResearchers at the Institute for the Developing Mind at Children’s
Hospital Los Angeles have analyzed current gene-disease findings to understand
why people with neurodevelopmental and mental illness often have physical
disorders.Their... Read More
Published on August 30, 2016
biodegradable scaffold (left) and human tissue-engineered liver (right)A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.... Read More
Published on August 26, 2016
Delirium is an acute neurologic dysfunction, defined by the
DSM IV as an acute change in consciousness with impairments in attention and
cognition. Over the decades critical care literature has referred to the
condition with a variety of terms, most commonly ICU
psychosis.... Read More