Research Blog
Published on November 17, 2016
Human Native Lung (left) and Tissue Engineered Lung (right)Scientists at Children’s Hospital Los Angeles have developed
a tissue-engineered model of lung and trachea which contains the diverse cell
types present in the human respiratory tract.
The study, led by principal... Read More
Published on November 4, 2016
Children with sleep apnea may
be at increased risk for overnight respiratory events (ORE) following
anesthesia. But researchers at
Children’s Hospital Los Angeles (CHLA) wondered if the practice of
hospitalizing a child overnight following sedation for certain non-surgical... Read More
Published on October 27, 2016
A study by researchers from The Saban Research Institute of
Children’s Hospital Los Angeles reveals a promising therapeutic target for
improving lung function in infants.
Their study, now published online
by the American Journal of Physiology-Lung Cellular and Molecular... Read More
Published on October 17, 2016
Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176
cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD.
Researchers at The Saban Research
Institute of Children’s Hospital Los Angeles have identified an unsuspected and
critical role... Read More
Published on October 12, 2016
Recently, Yoshinori
Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his
discoveries of mechanisms for a fundamental process called autophagy. Mutations
in autophagy genes can cause disease, and disturbances in the autophagic
process can lead to diabetes,... Read More
Published on September 30, 2016
The Food and Drug Administration has approved the first drug to treat patients with
Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in
childhood. Some experts contend that not enough evidence exists to prove the
drug – eteplirsen – is effective, because... Read More
Published on September 23, 2016
Military personnel can be exposed to dusts and toxicants in
the field that may contribute to lung disease. The available technologies to
detect early-stage alterations of lung function in patients require a long
processing time and lack satisfactory sensitivity and resolution,... Read More
Published on September 16, 2016
Recent studies have indicated an increased need for preventive
mental health and social services among Filipinos, in part because of higher
rates of problem behaviors such as substance use, high school dropout, and teen
births compared to other Asian subgroups. Filipino... Read More
Published on September 14, 2016
In a first-of-its-kind look at human kidney development,
researchers at The Saban Research Institute of Children’s Hospital Los Angeles
have isolated human nephron progenitor (NP) cells. Their results, published online in the
journal Stem Cell Translational Medicine,
will help... Read More
Published on September 9, 2016
Surface of the mouse colon repaired by stem cells after a flare of
ulcerative colitis. The different colors show the contributions of individual
stem cells as they have multiplied to patch the breaks, or ulcers, in the
colonic surface. These ulcers were originally caused by the... Read More
Published on September 6, 2016
Genetic Intersection of Conditions AnalyzedResearchers at the Institute for the Developing Mind at Children’s
Hospital Los Angeles have analyzed current gene-disease findings to understand
why people with neurodevelopmental and mental illness often have physical
disorders.Their... Read More
Published on August 30, 2016
biodegradable scaffold
(left) and human tissue-engineered liver (right)A research team led by
investigators at The Saban Research Institute of Children’s Hospital Los
Angeles has generated functional human and mouse tissue-engineered liver from
adult stem and progenitor cells.... Read More
Published on August 26, 2016
Delirium is an acute neurologic dysfunction, defined by the
DSM IV as an acute change in consciousness with impairments in attention and
cognition. Over the decades critical care literature has referred to the
condition with a variety of terms, most commonly ICU
psychosis.... Read More
Published on August 23, 2016
An article aimed at kids 10 to 15-years old by researchers
Elizabeth R. Sowell, PhD, Kristina Uban and Megan Herting from Children’s Hospital
Los Angeles asks the provocative question: Imagine that your family was given a
million dollars. How would your life
change?
The article... Read More
Published on August 19, 2016
In an innovative, first-in-pediatrics study, available only at Children’s
Hospital Los Angeles (CHLA), researchers will be enrolling children between 1
and 18 years of age who have certain types of relapsed or treatment-resistant
cancer.The aim of this investigator-initiated... Read More
Published on August 16, 2016
Study suggests substantial complications may impact
daily activities, long after initial cancer diagnosisA team of researchers from nine leading academic hospitals
and research centers have published a paper in the early online edition of the
journal Cancer
that describes... Read More
Published on August 9, 2016
Limiting screen time is often talked about for middle- and
high school students. But, should
parents worry about how much time their preschoolers are spending in front of a
tablet? While adults and caregivers find it easy to entertain or
distract little kids with a smart phone... Read More
Published on August 5, 2016
Five physician-scientists
with the Center for Childhood Cancer and Blood Diseases at Children’s Hospital
Los Angeles recently received grants from the St. Baldrick’s Foundation, the
largest private funder of childhood cancer research. Theirs are just some of
the innovative... Read More
Published on August 2, 2016
Osteoporosis is a major problem in public health with
significant costs both in healthcare dollars and human potential. Generally
known as a condition effecting older women, and to a lesser extent, older men,
this condition originates in childhood. Fragile bones can also occur... Read More
Published on July 29, 2016
A study led by researchers at The Saban Research Institute
of Children’s Hospital Los Angeles (CHLA) suggests that maternal HIV infection
influences the microbiome of their HIV-uninfected infants. Their findings, reported online in the
journal Science Translational Medicine
on... Read More