Research Blog
Published on April 18, 2017
“My goal is to decrease childhood blindness by treating
pediatric eye disease in an innovative way,” says Bibiana
Jin Reiser, MD, MS, director of the Cornea and Glaucoma Institute
at CHLA. Using technology developed for adults, she is optimizing it to treat
children.“The disease... Read More
Published on April 17, 2017
Research is a team sport. Each advance is incremental –
small but crucial in reaching the next, significant step toward finding a
solution. Science is currently under a great deal of scrutiny
because of how it is conducted
and how it is funded. At Children’s Hospital Los... Read More
Published on April 5, 2017
Zebrafish
heart with prominent coronary vessels (marked by transgenic fluorescent
reporters)Heart disease is among the leading causes of death for both
adults and children. A heart attack (or myocardial infarction) occurs when the
heart is deprived of oxygen due to blockage of a... Read More
Published on March 20, 2017
Brain scans of chronically depressed patients before and
during treatment. Left: Before treatment, depressed patients had a thicker
cortex in the frontal, temporal and parietal lobes of the brain (shown in red).
Right: Over 10 weeks of medication, these regions (shown in
blue)... Read More
Published on March 3, 2017
In a study led by Barbara
Driscoll, PhD, of The Saban Research Institute of Children’s Hospital Los
Angeles, researchers demonstrate, for the first time that inhaled resveratrol
treatments slow aging-related degenerative changes in mouse lung. Lung aging, characterized by... Read More
Published on February 8, 2017
Brain activity of spider phobic people during repeated presentation
of pictures of spiders - when they were aware of them (left column),
and when they were not aware of them (right column). The phobic
people processed the spider pictures significantly more when they were not... Read More
Published on January 30, 2017
Investigators at Children’s Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are... Read More
Published on January 9, 2017
Characterized by repetition of sounds, syllables, or words;
prolongation of sounds; and interruptions in speech, stuttering occurs most often in children between the ages of
2 and 6 as they are developing their language skills. While 75 percent outgrow or recover
from stuttering... Read More
Published on January 3, 2017
Innate immune cells of the myeloid lineage
(primarily macrophages and neutrophils) surrounding the epithelial crypts in
inflamed colonic tissue.
Inflammatory Bowel Disease (IBD) is a debilitating,
incurable condition affecting approximately 1.5 million... Read More
Published on December 13, 2016
Doctors in training, known as medical
residents, often find themselves tasked with significant clinical
responsibilities while continuing to learn how to be a physician. Many
hospitals offer lecture conferences to supplement the education of residents,
but turnout to these... Read More
Published on December 6, 2016
Investigators from Children’s Hospital Los Angeles and 37
other Children’s Oncology Group hospitals in the U.S. and Canada have
determined that sodium thiosulfate prevents cisplatin-induced hearing loss in
children and adolescents with cancer. Results of this randomized,... Read More
Published on November 29, 2016
Differences in
Neural Density between Stuttering and Control Participants Blue: reduced neural density in stutterers; Red: increased neural density in stutterersResearchers at Children’s Hospital
Los Angeles (CHLA) have conducted the first study of its kind, using proton... Read More
Published on November 17, 2016
Human Native Lung (left) and Tissue Engineered Lung (right)Scientists at Children’s Hospital Los Angeles have developed
a tissue-engineered model of lung and trachea which contains the diverse cell
types present in the human respiratory tract.
The study, led by principal... Read More
Published on November 4, 2016
Children with sleep apnea may
be at increased risk for overnight respiratory events (ORE) following
anesthesia. But researchers at
Children’s Hospital Los Angeles (CHLA) wondered if the practice of
hospitalizing a child overnight following sedation for certain non-surgical... Read More
Published on October 27, 2016
A study by researchers from The Saban Research Institute of
Children’s Hospital Los Angeles reveals a promising therapeutic target for
improving lung function in infants.
Their study, now published online
by the American Journal of Physiology-Lung Cellular and Molecular... Read More
Published on October 17, 2016
Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176
cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD.
Researchers at The Saban Research
Institute of Children’s Hospital Los Angeles have identified an unsuspected and
critical role... Read More
Published on October 12, 2016
Recently, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his discoveries of mechanisms for a fundamental process called autophagy. Mutations in autophagy genes can cause disease, and disturbances in the autophagic process can lead to diabetes,... Read More
Published on September 30, 2016
The Food and Drug Administration has approved the first drug to treat patients with
Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in
childhood. Some experts contend that not enough evidence exists to prove the
drug – eteplirsen – is effective, because... Read More
Published on September 23, 2016
Military personnel can be exposed to dusts and toxicants in
the field that may contribute to lung disease. The available technologies to
detect early-stage alterations of lung function in patients require a long
processing time and lack satisfactory sensitivity and resolution,... Read More
Published on September 16, 2016
Recent studies have indicated an increased need for preventive
mental health and social services among Filipinos, in part because of higher
rates of problem behaviors such as substance use, high school dropout, and teen
births compared to other Asian subgroups. Filipino... Read More