Research Blog

Published on November 17, 2016
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Human Native Lung (left) and Tissue Engineered Lung (right)Scientists at Children’s Hospital Los Angeles have developed a tissue-engineered model of lung and trachea which contains the diverse cell types present in the human respiratory tract.  The study, led by principal... Read More
Published on November 4, 2016
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Children with sleep apnea may be at increased risk for overnight respiratory events (ORE) following anesthesia.  But researchers at Children’s Hospital Los Angeles (CHLA) wondered if the practice of hospitalizing a child overnight following sedation for certain non-surgical... Read More
Published on October 27, 2016
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A study by researchers from The Saban Research Institute of Children’s Hospital Los Angeles reveals a promising therapeutic target for improving lung function in infants. Their study, now published online by the American Journal of Physiology-Lung Cellular and Molecular... Read More
Published on October 17, 2016
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Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176 cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD. Researchers at The Saban Research Institute of Children’s Hospital Los Angeles have identified an unsuspected and critical role... Read More
Published on October 12, 2016
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Recently, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his discoveries of mechanisms for a fundamental process called autophagy. Mutations in autophagy genes can cause disease, and disturbances in the autophagic process can lead to diabetes,... Read More
Published on September 30, 2016
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The Food and Drug Administration has approved the first drug to treat patients with Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in childhood. Some experts contend that not enough evidence exists to prove the drug – eteplirsen – is effective, because... Read More
Published on September 23, 2016
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Military personnel can be exposed to dusts and toxicants in the field that may contribute to lung disease. The available technologies to detect early-stage alterations of lung function in patients require a long processing time and lack satisfactory sensitivity and resolution,... Read More
Published on September 16, 2016
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Recent studies have indicated an increased need for preventive mental health and social services among Filipinos, in part because of higher rates of problem behaviors such as substance use, high school dropout, and teen births compared to other Asian subgroups. Filipino... Read More
Published on September 14, 2016
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In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have isolated human nephron progenitor (NP) cells.  Their results, published online in the journal Stem Cell Translational Medicine, will help... Read More
Published on September 9, 2016
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Surface of the mouse colon repaired by stem cells after a flare of ulcerative colitis. The different colors show the contributions of individual stem cells as they have multiplied to patch the breaks, or ulcers, in the colonic surface. These ulcers were originally caused by the... Read More
Published on September 6, 2016
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Genetic Intersection of Conditions AnalyzedResearchers at the Institute for the Developing Mind at Children’s Hospital Los Angeles have analyzed current gene-disease findings to understand why people with neurodevelopmental and mental illness often have physical disorders.Their... Read More
Published on August 30, 2016
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biodegradable scaffold (left) and human tissue-engineered liver (right)A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.... Read More
Published on August 26, 2016
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Delirium is an acute neurologic dysfunction, defined by the DSM IV as an acute change in consciousness with impairments in attention and cognition. Over the decades critical care literature has referred to the condition with a variety of terms, most commonly ICU psychosis.... Read More
Published on August 23, 2016
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An article aimed at kids 10 to 15-years old by researchers Elizabeth R. Sowell, PhD, Kristina Uban and Megan Herting from Children’s Hospital Los Angeles asks the provocative question: Imagine that your family was given a million dollars.  How would your life change? The article... Read More
Published on August 19, 2016
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In an innovative, first-in-pediatrics study, available only at Children’s Hospital Los Angeles (CHLA), researchers will be enrolling children between 1 and 18 years of age who have certain types of relapsed or treatment-resistant cancer.The aim of this investigator-initiated... Read More
Published on August 16, 2016
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Study suggests substantial complications may impact daily activities, long after initial cancer diagnosisA team of researchers from nine leading academic hospitals and research centers have published a paper in the early online edition of the journal Cancer that describes... Read More
Published on August 9, 2016
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Limiting screen time is often talked about for middle- and high school students. But, should parents worry about how much time their preschoolers are spending in front of a tablet? While adults and caregivers find it easy to entertain or distract little kids with a smart phone... Read More
Published on August 5, 2016
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Five physician-scientists with the Center for Childhood Cancer and Blood Diseases at Children’s Hospital Los Angeles recently received grants from the St. Baldrick’s Foundation, the largest private funder of childhood cancer research. Theirs are just some of the innovative... Read More
Published on August 2, 2016
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Osteoporosis is a major problem in public health with significant costs both in healthcare dollars and human potential. Generally known as a condition effecting older women, and to a lesser extent, older men, this condition originates in childhood. Fragile bones can also occur... Read More
Published on July 29, 2016
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A study led by researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) suggests that maternal HIV infection influences the microbiome of their HIV-uninfected infants.  Their findings, reported online in the journal Science Translational Medicine on... Read More

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