Research Blog
Published on January 20, 2016
In a new article published in Trends in Cognitive Sciences, corresponding
author Elizabeth
Sowell, PhD of Children’s
Hospital Los Angeles, in collaboration with authors from Harvard Medical
School and San Diego State University, reviewed ongoing research efforts to
determine... Read More
Published on December 30, 2015
Every year brings more
breakthroughs and discoveries in the field of pediatric medicine, many from
right here in Children’s Hospital Los Angeles. Today, we’re recapping the top 5
most popular ResearCHLA stories of the year. Stay tuned for many more in the new
year!1. Researchers... Read More
Published on December 28, 2015
Bubbles ‘n BowelsSmall bowel syndrome (SBS), a disorder characterized by
malabsorption of nutrients due to removal of parts of the small intestine,
affects roughly 9000 children and 3500 adults in the United States annually. Surgical
removal of the intestine is often done in... Read More
Published on December 24, 2015
Either way, we hope your holidays are stimulating!from The Saban Research Institute of Children’s Hospital Los Angeles
Published on December 20, 2015
Sex-based differences in incidence and long-term outcomes
have been well documented in pediatric cancer patients. Investigators at Children’s Hospital Los Angeles have now
discovered similar differences in acute side effects due to treatment in
pediatric patients with acute... Read More
Published on December 11, 2015
Purple haze, all in my lungA variety of signaling molecules
control the branching program by which the lung grows and develops. In this
image we see the beginning of normal branching that occurs at budding points of
the lung known as epithelial tips. Researchers at Children’s... Read More
Published on December 4, 2015
Newborn brain images show total maternal prenatal iron
intake (purple) correlates with tissue organization and development. Image
courtesy of Bradley
Peterson, MD, The
Saban Research Institute, Children’s Hospital Los
Angeles.In the first study of its
kind, researchers have... Read More
Published on December 2, 2015
Dr. Joe Church, shown with patient Cristina Jade
Peña in 1994. Today, at age 31, Cristina is leading “a wonderful and
happy life, because of medical advancements, and the lifesaving care and
treatment by Dr. Church and his team at CHLA.”Joseph
Church, MD, has a thick stack of... Read More
Published on December 1, 2015
Individuals with autism spectrum disorder (ASD) often have
difficulty recognizing and interpreting how facial expressions convey various
emotions – from joy to puzzlement, sadness to anger. This can make it difficult for an individual
with ASD to successfully navigate social... Read More
Published on November 19, 2015
Birth of a NeuronWhat can the developing brain, specifically the birth of
neurons (green), tell us about predisposition to childhood obesity and diabetes?
Researchers at Children’s Hospital Los Angeles, led by Sebastien Bouret, PhD, are
investigating how neuron development in... Read More
Published on November 9, 2015
More
children are surviving malignant brain tumors than in the past, thanks to intense
treatments using platinum-based chemotherapy.
Unfortunately, the therapy has a known side effect of permanent hearing
loss, resulting from damage to the inner ear. Investigators at Children’s... Read More
Published on November 4, 2015
Bacterial infections can cause severe medical complications
in newborns, such as neonatal meningitis – the inflammation of the protective
membranes of the central nervous system. Exactly how newborns contract these infections
however remains unknown. Research conducted at... Read More
Published on October 30, 2015
Decreased lung development often occurs in babies born prematurely.
Known as bronchopulmonary dysplasia, the condition is linked to decreased
numbers of specialized lung cells known as lipofibroblasts (LIF). Here,
researchers at Children’s
Hospital Los Angeles demonstrate how... Read More
Published on October 28, 2015
Left: Untreated cancer
cells. Right: Cells treated with the nanoparticle complex HerMn, which is
cytotoxic to tumor cells (disrupting the cytoskeleton and structure of these
cells as shown above) while simultaneously enhancing MRI contrast. Image
courtesy of Karn Sorasaenee, PhD... Read More
Published on October 15, 2015
Most babies are leaving their
mark on mothers, detectable even after birth, in the form of fetal cells left
behind after pregnancy. Image courtesy of Shutterstock.A recent
study published in Molecular Human Reproduction reports evidence of fetal cells escaping
the womb and... Read More
Published on October 14, 2015
Researchers use MRS imaging to
study effects of hypothermia for infants with decreased oxygen to the brainCHLA’s team of nurses
and medical professionals administer hypothermia treatments to newborns to
prevent brain damage caused by an inhibited oxygen supply to the brain.... Read More
Published on October 10, 2015
How natural killer immune cells can fight cancerNatural killer (NK) immune
cells can identify infected or potentially cancerous cells in the body and
induce cell death. Image courtesy of Shutterstock.Cancer cells present a unique challenge to the immune system
in that they are... Read More
Published on October 7, 2015
Tissue-engineered colon generated from cells from a patient with Hirschsprung’s disease. Nerve cells shown in green. Image courtesy of Grikscheit Laboratory, The Saban Research Institute, CHLA.A study by scientists at Children’s Hospital Los Angeles has shown that tissue-... Read More
Published on October 5, 2015
Neural
dysfunction in cognitive control circuits during adolescence could be predictor
of psychotic disordersThose at clinically high risk (CHR) for psychotic disorders on average
had lower levels of conflict-related brain activity compared to healthy
controls (HC). VS = ventral... Read More
Published on October 1, 2015
In a new
study published in the journal Pediatric
Emergency Care, investigators at Children’s
Hospital Los Angeles piloted a brief mental health screening tool to be
used with patients accessing the emergency department for medical complaints
who might be at risk... Read More