Research Blog
Published on November 9, 2015
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children are surviving malignant brain tumors than in the past, thanks to intense
treatments using platinum-based chemotherapy.
Unfortunately, the therapy has a known side effect of permanent hearing
loss, resulting from damage to the inner ear. Investigators at Children’s... Read More
Published on October 30, 2015
Decreased lung development often occurs in babies born prematurely.
Known as bronchopulmonary dysplasia, the condition is linked to decreased
numbers of specialized lung cells known as lipofibroblasts (LIF). Here,
researchers at Children’s
Hospital Los Angeles demonstrate how... Read More
Published on October 28, 2015
Left: Untreated cancer
cells. Right: Cells treated with the nanoparticle complex HerMn, which is
cytotoxic to tumor cells (disrupting the cytoskeleton and structure of these
cells as shown above) while simultaneously enhancing MRI contrast. Image
courtesy of Karn Sorasaenee, PhD... Read More
Published on October 15, 2015
Most babies are leaving their
mark on mothers, detectable even after birth, in the form of fetal cells left
behind after pregnancy. Image courtesy of Shutterstock.A recent
study published in Molecular Human Reproduction reports evidence of fetal cells escaping
the womb and... Read More
Published on October 14, 2015
Researchers use MRS imaging to
study effects of hypothermia for infants with decreased oxygen to the brainCHLA’s team of nurses
and medical professionals administer hypothermia treatments to newborns to
prevent brain damage caused by an inhibited oxygen supply to the brain.... Read More
Published on October 7, 2015
Tissue-engineered colon generated from cells from a patient with Hirschsprung’s disease. Nerve cells shown in green. Image courtesy of Grikscheit Laboratory, The Saban Research Institute, CHLA.A study by scientists at Children’s Hospital Los Angeles has shown that tissue-... Read More
Published on October 5, 2015
Neural
dysfunction in cognitive control circuits during adolescence could be predictor
of psychotic disordersThose at clinically high risk (CHR) for psychotic disorders on average
had lower levels of conflict-related brain activity compared to healthy
controls (HC). VS = ventral... Read More
Published on October 1, 2015
In a new
study published in the journal Pediatric
Emergency Care, investigators at Children’s
Hospital Los Angeles piloted a brief mental health screening tool to be
used with patients accessing the emergency department for medical complaints
who might be at risk... Read More
Published on September 30, 2015
Children’s Hospital
Los Angeles Awarded $8 Million as Part of Landmark NIH Study to Find the AnswerAs part of a landmark study about the effects of
adolescent substance use on the developing brain called the Adolescent Brain
Cognitive Development (ABCD) study, Children’s... Read More
Published on September 28, 2015
The gastrointestinal (GI) tract, which includes the stomach
and intestines, is controlled by the enteric nervous system (ENS), which
functions almost like a “second brain” controlling the movement of food
throughout the tract and its digestion. The ENS is embedded within the GI... Read More
Published on September 25, 2015
Investigators
at Children’s
Hospital Los Angeles
have found that a common therapeutic target for the treatment of inflammatory
bowel disease (IBD) may actually protect against intestinal inflammation or
colitis by inhibiting pathogenic T immune cells. This discovery, reported in... Read More
Published on September 19, 2015
Researchers at Children’s
Hospital Los Angeles have received an $8.4 million grant from the National
Institutes of Health (NIH) to conduct research to improve HIV care and
prevention in a study focusing on Black, Latino and multiracial gay and
bisexual young men – a group at the... Read More
Published on September 4, 2015
CHLA researcher Elizabeth
Sowell, PhD, was featured on NPR’s Marketplace Morning Report on Thursday,
September 3 for her research study finding an association between socioeconomic
status and brain development. Check out her interview here as well as our own post below from... Read More
Published on August 26, 2015
Cross-section of mouse
gastrocnemius muscle, courtesy of Lily Chao, MD, Children’s Hospital, Los
AngelesImportant for quick leg movements like running and jumping,
the gastrocnemius muscle is connected to the Achilles tendon and spans the back
of the lower leg. Researchers at... Read More
Published on August 25, 2015
Seeing the arm ripped off of one’s favorite SpongeBob
SquarePants plush pillow can be heartbreaking for a child. But rather than
grieve its loss, a young Michael Quintero got out his mother’s sewing kit and
slowly stitched SpongeBob back together. While too young to truly... Read More
Published on August 20, 2015
In a word? Data.Left: The Great
Library of Alexandria, O. Von Corven, 1st Century, Public DomainRight: Big Data Image,
Courtesy of Shutterstock
“The library of Alexandria was a great data
repository,” began Randall
Wetzel, MD, during a presentation at Children’s... Read More
Published on August 17, 2015
Researchers demonstrate better outcomes using immune therapy drug called alemtuzumab in transplant patients with non-malignant genetic diseases of blood cellsComputer modeling of the monoclonal antibody alemtuzumab, which CHLA researchers have shown helps reduce graft rejections... Read More
Published on August 7, 2015
When life gives you
lemons, make some lemonade.Alexandra “Alex” Scott gave new meaning to the saying when,
at the age of four, she began selling lemonade to fund pediatric cancer
research. She had been diagnosed with neuroblastoma, a pediatric cancer of the
sympathetic nervous... Read More
Published on August 5, 2015
Researchers at Children’s
Hospital Los Angeles, led by principal investigator and acting division head
of Neurology
Wendy Mitchell, MD, have been at the forefront of studying treatment and
outcome Opsoclonus-Myoclonus
Syndrome or OMS (also known as the “dancing eyes” syndrome or... Read More
Published on August 3, 2015
How should we approach and study Johanson-Blizzard Syndrome?Though incredibly rare, Johanson-Blizzard Syndrome (JBS) requires intervention from multiple medical fields. Complications this syndrome presents in many areas of the body can necessitate treatment over the course of... Read More