Research Blog

Published on November 9, 2015
More children are surviving malignant brain tumors than in the past, thanks to intense treatments using platinum-based chemotherapy. Unfortunately, the therapy has a known side effect of permanent hearing loss, resulting from damage to the inner ear. Investigators at Children’s... Read More
Published on October 30, 2015
Decreased lung development often occurs in babies born prematurely. Known as bronchopulmonary dysplasia, the condition is linked to decreased numbers of specialized lung cells known as lipofibroblasts (LIF). Here, researchers at Children’s Hospital Los Angeles demonstrate how... Read More
Published on October 28, 2015
Left: Untreated cancer cells. Right: Cells treated with the nanoparticle complex HerMn, which is cytotoxic to tumor cells (disrupting the cytoskeleton and structure of these cells as shown above) while simultaneously enhancing MRI contrast. Image courtesy of Karn Sorasaenee, PhD... Read More
Published on October 15, 2015
Most babies are leaving their mark on mothers, detectable even after birth, in the form of fetal cells left behind after pregnancy. Image courtesy of Shutterstock.A recent study published in Molecular Human Reproduction reports evidence of fetal cells escaping the womb and... Read More
Published on October 14, 2015
Researchers use MRS imaging to study effects of hypothermia for infants with decreased oxygen to the brainCHLA’s team of nurses and medical professionals administer hypothermia treatments to newborns to prevent brain damage caused by an inhibited oxygen supply to the brain.... Read More
Published on October 7, 2015
Tissue-engineered colon generated from cells from a patient with Hirschsprung’s disease. Nerve cells shown in green. Image courtesy of Grikscheit Laboratory, The Saban Research Institute, CHLA.A study by scientists at Children’s Hospital Los Angeles has shown that tissue-... Read More
Published on October 5, 2015
Neural dysfunction in cognitive control circuits during adolescence could be predictor of psychotic disordersThose at clinically high risk (CHR) for psychotic disorders on average had lower levels of conflict-related brain activity compared to healthy controls (HC). VS = ventral... Read More
Published on October 1, 2015
In a new study published in the journal Pediatric Emergency Care, investigators at Children’s Hospital Los Angeles piloted a brief mental health screening tool to be used with patients accessing the emergency department for medical complaints who might be at risk... Read More
Published on September 30, 2015
Children’s Hospital Los Angeles Awarded $8 Million as Part of Landmark NIH Study to Find the AnswerAs part of a landmark study about the effects of adolescent substance use on the developing brain called the Adolescent Brain Cognitive Development (ABCD) study, Children’s... Read More
Published on September 28, 2015
The gastrointestinal (GI) tract, which includes the stomach and intestines, is controlled by the enteric nervous system (ENS), which functions almost like a “second brain” controlling the movement of food throughout the tract and its digestion. The ENS is embedded within the GI... Read More
Published on September 25, 2015
Investigators at Children’s Hospital Los Angeles have found that a common therapeutic target for the treatment of inflammatory bowel disease (IBD) may actually protect against intestinal inflammation or colitis by inhibiting pathogenic T immune cells. This discovery, reported in... Read More
Published on September 19, 2015
Researchers at Children’s Hospital Los Angeles have received an $8.4 million grant from the National Institutes of Health (NIH) to conduct research to improve HIV care and prevention in a study focusing on Black, Latino and multiracial gay and bisexual young men – a group at the... Read More
Published on September 4, 2015
CHLA researcher Elizabeth Sowell, PhD, was featured on NPR’s Marketplace Morning Report on Thursday, September 3 for her research study finding an association between socioeconomic status and brain development. Check out her interview here as well as our own post below from... Read More
Published on August 26, 2015
Cross-section of mouse gastrocnemius muscle, courtesy of Lily Chao, MD, Children’s Hospital, Los AngelesImportant for quick leg movements like running and jumping, the gastrocnemius muscle is connected to the Achilles tendon and spans the back of the lower leg. Researchers at... Read More
Published on August 25, 2015
Seeing the arm ripped off of one’s favorite SpongeBob SquarePants plush pillow can be heartbreaking for a child. But rather than grieve its loss, a young Michael Quintero got out his mother’s sewing kit and slowly stitched SpongeBob back together. While too young to truly... Read More
Published on August 20, 2015
In a word? Data.Left: The Great Library of Alexandria, O. Von Corven, 1st Century, Public DomainRight: Big Data Image, Courtesy of Shutterstock “The library of Alexandria was a great data repository,” began Randall Wetzel, MD, during a presentation at Children’s... Read More
Published on August 17, 2015
Researchers demonstrate better outcomes using immune therapy drug called alemtuzumab in transplant patients with non-malignant genetic diseases of blood cellsComputer modeling of the monoclonal antibody alemtuzumab, which CHLA researchers have shown helps reduce graft rejections... Read More
Published on August 7, 2015
When life gives you lemons, make some lemonade.Alexandra “Alex” Scott gave new meaning to the saying when, at the age of four, she began selling lemonade to fund pediatric cancer research. She had been diagnosed with neuroblastoma, a pediatric cancer of the sympathetic nervous... Read More
Published on August 5, 2015
Researchers at Children’s Hospital Los Angeles, led by principal investigator and acting division head of Neurology Wendy Mitchell, MD, have been at the forefront of studying treatment and outcome Opsoclonus-Myoclonus Syndrome or OMS (also known as the “dancing eyes” syndrome or... Read More
Published on August 3, 2015
How should we approach and study Johanson-Blizzard Syndrome?Though incredibly rare, Johanson-Blizzard Syndrome (JBS) requires intervention from multiple medical fields. Complications this syndrome presents in many areas of the body can necessitate treatment over the course of... Read More