Research Blog

Published on January 21, 2016
A genetic variation, or the “s” allele, was associated with thicker cortex in the high risk (top row) but with thinner cortex in the low risk (bottom row) individuals. Image courtesy of Ravi Bansal, PhD, Children’s Hospital Los Angeles.Building on a 30-year, three-generation... Read More
Published on January 20, 2016
In a new article published in Trends in Cognitive Sciences, corresponding author Elizabeth Sowell, PhD of Children’s Hospital Los Angeles, in collaboration with authors from Harvard Medical School and San Diego State University, reviewed ongoing research efforts to determine... Read More
Published on December 28, 2015
Bubbles ‘n BowelsSmall bowel syndrome (SBS), a disorder characterized by malabsorption of nutrients due to removal of parts of the small intestine, affects roughly 9000 children and 3500 adults in the United States annually. Surgical removal of the intestine is often done in... Read More
Published on December 24, 2015
Either way, we hope your holidays are stimulating!from The Saban Research Institute of Children’s Hospital Los Angeles Read More
Published on December 20, 2015
Sex-based differences in incidence and long-term outcomes have been well documented in pediatric cancer patients. Investigators at Children’s Hospital Los Angeles have now discovered similar differences in acute side effects due to treatment in pediatric patients with acute... Read More
Published on December 11, 2015
Purple haze, all in my lungA variety of signaling molecules control the branching program by which the lung grows and develops. In this image we see the beginning of normal branching that occurs at budding points of the lung known as epithelial tips. Researchers at Children’s... Read More
Published on December 4, 2015
Newborn brain images show total maternal prenatal iron intake (purple) correlates with tissue organization and development. Image courtesy of Bradley Peterson, MD, The Saban Research Institute, Children’s Hospital Los Angeles.In the first study of its kind, researchers have... Read More
Published on December 2, 2015
Dr. Joe Church, shown with patient Cristina Jade Peña in 1994.  Today, at age 31, Cristina is leading “a wonderful and happy life, because of medical advancements, and the lifesaving care and treatment by Dr. Church and his team at CHLA.”Joseph Church, MD, has a thick stack of... Read More
Published on December 1, 2015
Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger.  This can make it difficult for an individual with ASD to successfully navigate social... Read More
Published on November 19, 2015
Birth of a NeuronWhat can the developing brain, specifically the birth of neurons (green), tell us about predisposition to childhood obesity and diabetes? Researchers at Children’s Hospital Los Angeles, led by Sebastien Bouret, PhD, are investigating how neuron development in... Read More
Published on November 9, 2015
More children are surviving malignant brain tumors than in the past, thanks to intense treatments using platinum-based chemotherapy. Unfortunately, the therapy has a known side effect of permanent hearing loss, resulting from damage to the inner ear. Investigators at Children’s... Read More
Published on October 30, 2015
Decreased lung development often occurs in babies born prematurely. Known as bronchopulmonary dysplasia, the condition is linked to decreased numbers of specialized lung cells known as lipofibroblasts (LIF). Here, researchers at Children’s Hospital Los Angeles demonstrate how... Read More
Published on October 28, 2015
Left: Untreated cancer cells. Right: Cells treated with the nanoparticle complex HerMn, which is cytotoxic to tumor cells (disrupting the cytoskeleton and structure of these cells as shown above) while simultaneously enhancing MRI contrast. Image courtesy of Karn Sorasaenee, PhD... Read More
Published on October 15, 2015
Most babies are leaving their mark on mothers, detectable even after birth, in the form of fetal cells left behind after pregnancy. Image courtesy of Shutterstock.A recent study published in Molecular Human Reproduction reports evidence of fetal cells escaping the womb and... Read More
Published on October 14, 2015
Researchers use MRS imaging to study effects of hypothermia for infants with decreased oxygen to the brainCHLA’s team of nurses and medical professionals administer hypothermia treatments to newborns to prevent brain damage caused by an inhibited oxygen supply to the brain.... Read More
Published on October 7, 2015
Tissue-engineered colon generated from cells from a patient with Hirschsprung’s disease. Nerve cells shown in green. Image courtesy of Grikscheit Laboratory, The Saban Research Institute, CHLA.A study by scientists at Children’s Hospital Los Angeles has shown that tissue-... Read More
Published on October 5, 2015
Neural dysfunction in cognitive control circuits during adolescence could be predictor of psychotic disordersThose at clinically high risk (CHR) for psychotic disorders on average had lower levels of conflict-related brain activity compared to healthy controls (HC). VS = ventral... Read More
Published on October 1, 2015
In a new study published in the journal Pediatric Emergency Care, investigators at Children’s Hospital Los Angeles piloted a brief mental health screening tool to be used with patients accessing the emergency department for medical complaints who might be at risk... Read More
Published on September 30, 2015
Children’s Hospital Los Angeles Awarded $8 Million as Part of Landmark NIH Study to Find the AnswerAs part of a landmark study about the effects of adolescent substance use on the developing brain called the Adolescent Brain Cognitive Development (ABCD) study, Children’s... Read More
Published on September 28, 2015
The gastrointestinal (GI) tract, which includes the stomach and intestines, is controlled by the enteric nervous system (ENS), which functions almost like a “second brain” controlling the movement of food throughout the tract and its digestion. The ENS is embedded within the GI... Read More