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This study uses sensitive measures of brain blood flow an its response to change to inhaled oxygen levels to determine how the brain protects its oxygen supply.

To determine the extent that subtle brain injury, blood flow to the brain, and learning problems relate to type of brain tumor treatment given.

The objective of this study is to learn how anemia may affect oxygen delivery to the brain as measured by magnetic resonance imaging (MRI). By studying this, we hope to better identify people who may benefit from correction of their anemia.

The objective of this study is to better understand how a single ventricular heart with Fontan physiology may affect brain health.

A study to look at how having chronic anemia impacts the brain.

To investigate bone health in cerebral palsy and the relationship between walking and bone health.

This study is a randomized, double-blind, active-controlled, titrated, parallel arm, multicenter study. It will compare the efficacy, safety and tolerability of twice daily Chronocort with twice daily IRHC (Cortef®) over a randomized treatment period of up to 52 weeks in participants aged 16 years and over with known classic CAH due to 21-hydroxylase deficiency. The primary efficacy assessment of biochemical responder rate and the key secondary assessments of dose responder rate and mean total daily dose will be assessed after 52 weeks of randomized treatment.

Develop better ways of screening and diagnosing certain types of brain injuries in infants and children who are born with and without congenital heart disease.

To evaluate the impact of non-Newtonian behavior on hemodynamic efficiency in children and young adults who have undergone the Fontan procedure.

We are studying the role of gut microbiome diversity on the mucosal and systemic responses to Ty21a vaccine. This is to determine if a given microbiota composition is associated with specific immune responses and to evaluate the impact of an oral typhoid vaccination on the human gut microbiota.