Anatomic Pathology

The Anatomic Pathology Division provides diagnostic services to Children's Hospital Los Angeles, including pathological evaluations of surgical specimens, biopsies and autopsies. Consultative services for childhood diseases are offered to other hospitals and physicians.

Anatomic Pathology resources include:

Autopsy and perinatal pathology: We offer advanced autopsy and perinatal pathology services with dedicated expert faculty who are also available for consultation.

Histology laboratory: Our laboratory prepares tissue for anatomic pathology studies and offers comprehensive histochemical and immunohistochemical stains for specialized pediatric diagnostics. We also offer technical services for other clinical laboratories.

Integrated molecular genomic diagnostics: Our pathologists, in collaboration with colleagues in the Division of Genomic Medicine, offer state-of-the-art molecular genetic and next-generation sequencing-based testing for pediatric tumors, along with fully integrated pathology genomic reporting.

Electron microscopy laboratory: We are one of the few remaining labs that can perform the full range of services to support ultrastructural analysis for clinical diagnosis. Our pathologists offer special expertise in pediatric renal disease, ciliopathies and other pediatric disorders.

Biorepository: We provide specialized collection, processing and storage of biospecimens for use by CHLA and outside researchers. Our current collection comprises over 22,000 patient samples with an emphasis on solid tumors and hematologic malignancies. We offer whole-slide scanning and image-analysis services for both clinical and research purposes.

Pathology core laboratory: We offer a full line of histopathology, immunohistochemistry (IHC), tissue microarray (TMA) construction and imaging services designed for the unique needs of researchers. We perform histochemical stains from routine H&Es to complex Gallyas silver stains and offer a full range of IHC services, including new antibody workups, double markers, and immunofluorescence on both paraffin-embedded and frozen tissue.

CHLA has many sophisticated research laboratories where childhood diseases are studied in depth; these laboratories use the services of our Biorepository and Pathology Core Laboratory.

Expertise

The Anatomic Pathology Division is staffed with a full range of Board-certified pathology subspecialists, including faculty with training in pediatric pathology, hematopathology, GI pathology, neuropathology, molecular genetic pathology and forensic pathology. This allows us to offer a wide range of specialized expertise in addition to pediatric pathology, including:

  • Autopsy and perinatal pathology
  • Cytopathology
  • Gastrointestinal pathology
  • Nephropathology
  • Neuromuscular pathology
  • Ultrastructural pathology
  • Hematopathology
  • Neuroblastoma
  • Brain tumors
  • Bone and soft tissue tumors
  • Molecular genetic pathology

Pediatric Pathology Fellowship

The Division of Anatomic Pathology also offers a Fellowship in Pediatric Pathology and participates with Keck School of Medicine USC in fellowships in Neuropathology and Hematopathology, all with the expectation that the graduates will qualified to take ACGME board examination in their respective subspecialties. The Outreach Division of CHLA offers a three month international fellowship for pathologists in other countries who are already in pathology practice and who wish to participate in an observership in a large pediatric medical center.

Pediatric Pathology Fellowship