Biostatistics Core

About Us

The Biostatistics Core at Children’s Hospital Los Angeles is jointly supported by The Saban Research Institute (TSRI) and the Southern California Clinical and Translational Science Institute (SC CTSI). Our goal is to support efficient and accurate data collection and analysis by providing a variety of consultation services, including research design, grant planning, data collection, data analysis, and consultation for presentations and publications.

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Services

The Biostatistics Core services range from planning of pilot studies and surveys, methodological help with data science, software development for specialized tasks, and data analysis. The Biostatistics Core expertise is in, but not limited to:

  1. Design experiments and surveys
  2. Select and perform proper analyses (General and generalized linear model; Multilevel (hierarchical) modeling; Structural equation modeling; Time series analysis; Survival analysis; Latent class/transition analysis; Longitudinal data analysis; Imaging generics structural equation modeling)
  3. Interpret results
  4. Write about statistical methods and results

For further information about the core services, please read:

  1. Rules of Engagement
  2. Scope of Work
  3. Authorship Agreement

To request, please visit the following link: Biostatistics Service Request Form

This Core participates in the CHLA Core Pilot Program. To learn more click here.

  • Fee Structure
  • Leadership
  • Core Acknowledgment in Publications

The Biostatistics Core is a charge-back service, with an initial free one-hour consultation. The Core will also provide a set number of hours of free service determined by an individual investigator’s needs and status. Once these hours have been used, the investigator has the option to purchase additional services on a recharge basis.

Complimentary Consultation Services

Service

Eligibility

Initial Consultation: 1 hour

Free for any project based at CHLA

Junior Investigators: 5 hours total

Junior investigators as defined by NIH and/or in an Assistant Professor classification

Career Development Scholars: 15 hours annually

All awardees of SC CTSI Institutional Career Development (ICD) Award or other NIH-sponsored career development award (e.g., K12, K23, K01, etc.) based at USC or CHLA.

SC CTSI Pilot Funding Awardees: 2 hours total

Free for SC CTSI Pilot Projects

Extramural Grant Planning: 3 hours total

Researchers who are preparing a grant for submission within 6 months. This includes consultation on issues related to:

  • Study/experimental design
  • Power/sample size
  • Randomization schema
  • Statistical analysis plan
  • Analysis of results
  • Data acquisition plan
  • Data cleaning and management
  • Data sharing plan

*Our top priority is to support NIH-funded, junior investigators and those applying for NIH funding

*Annual maximum is 15 total hours of free consultation (for all projects combined)

Fee Based Service

  • Any consultation or work performed after the initial consultation or outside of the complimentary services above will be charged $125/hour
  • It is also available to contract the Core services for your on-going projects, center, or institute via buying % of biostatisticians’ efforts instead of hourly recharge

Questions? Contact Ji Hoon Ryoo, PhD, jryoo@chla.usc.edu or call (323) 361-8203

Core Director: Ji Hoon Ryoo, PhD

As a quantitative methodologist, Dr. Ryoo has the expertise and leadership in biostatistics and statistics. He has a broad background in education (including educational measurement, school psychology, and student’s learning), psychology (including behavior and cognition), statistics (including multilevel and longitudinal data analysis, structural equation modeling, and experimental design), and medical fields (including imaging genetics). As PI or co-Investigator on several university- and NSF-funded grants, Dr. Ryoo has developed innovative methodologies such as measurement invariance in longitudinal data, model selection for nonlinear growth curve and identification of nonlinear growth curves in heterogeneity, and then, applied the methodologies in contents areas including student’s preference in science education, student achievement in cognitive assessments, and early childhood mathematics.

Biostatistician: Choo Phei Wee, MS

Choo Phei received her Masters from Keck School of Medicine in Biostatistics from the Preventive Medicine Department at USC (2008). She has extensive experience in statistical analysis, data management and conducting analysis with national databases.

How to cite the Core in publications:

This work was supported by the Biostatistics Core at Children’s Hospital Los Angeles (CHLA), jointly supported by The Saban Research Institute and the Southern California Clinical and Translational Science Institute.

Recent publications include:

Jung, K., Cho, S. S., Lee, J., & Ryoo, J. H. (in press). An illustrative application of generalized structured component analysis for brain connectivity research. Behaviormetrika. https://doi.org/10.1007/s41237-019-00080-w

Pullen, P. C., Ashworth, K. E., & Ryoo, J. H. (in press). Prevalence rates of students identified for special education and their interstate variability: A longitudinal approach. Learning Disability Quarterly. https://doi.org/10.1177/0731948719837912

Pas, E. T., Ryoo, J. H., Musci, R., & Bradshaw, C. (2019). The effects of a state-wide scale-up of school-wide positive behavior intervention and supports on behavioral and academic outcomes: A quasi-experimental examination. Journal of School Psychology, 73, 41-55. https://doi.org/10.1016/j.jsp.2019.03.001

Vidmar AP, Salvy SJ, Pretlow R, Mittleman SD, Wee CP, Fink C, Steven Fox D, Raymond JK. An addiction-based mobile health weight loss intervention: protocol of a randomized controlled trial. Contemp Clin Trials. 2019 Mar; 78:11-19. doi: 10.1016/j.cct.2019.01.008. Epub 2019 Jan 14. PMID:30654026

Vidmar AP, Fink C, Torres B, Manzanarez B, Mittleman SD, Wee CP and Borzutzky C. Energy Mangement for Personalized Weight Reduction (EMPOWER) Program: Three-Year Outcome Data.  Gratis: Advances in Clinical Endocrinology and Metabolism. Published: March 10, 2019. 

Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittleman SD.  An addiction model-based mobile health weight loss intervention in adolescents with obesity.  Pediatr Obes. 2019 Feb;14(2):e12464. doi: 10.1111/ijpo.12464. Epub 2018 Aug 16.  PMID: 30117309

Lee, M., Ryoo, J. H., Chung, M., Anderson, J. G., Rose, K. M., & Williams, I. C. (in press). Effective interventions for depressive symptoms among caregivers of people with dementia: A systematic review and Meta-Analysis. Dementia: International Journal of Social Research and Practice. https://doi.org/10.1177/1471301218822640

Roberta M. Kato, Yoon-Chul Kim, Biswas Joshi, Shirleen Loloyan, Choo Phei Wee, Ziyue Wu, Winston H. Tran, Thomas G. Keens, Michael C. K. Khoo, Krishna S. Nayak, and Sally L. Davidson Ward. Upper Airway Narrowing during Central Apnea in Obese Adolescents. Ann Am Thorac Soc Vol 15, No 12, pp 1465–1471, Dec 2018. PMID: 30371114