Biostatistics and Data Management Core
The Biostatistics and Data Management Core at Children’s Hospital Los Angeles is jointly supported by The Saban Research Institute (TSRI) and the Southern California Clinical and Translational Science Institute (SC CTSI). Our goal is to support efficient and accurate data collection and analysis by providing a variety of consultation services, including research design, grant planning, data collection, data analysis, and consultation for presentations and publications.
The Biostatistics and Data Management Core services range from planning of pilot studies and surveys, methodological help with data science, software development for specialized tasks, and data analysis. The Biostatistics and Data Management Core expertise is in, but not limited to:
- Design experiments and surveys
- Select and perform proper analyses (General and generalized linear model; Multilevel (hierarchical) modeling; Structural equation modeling; Time series analysis; Survival analysis; Latent class/transition analysis; Longitudinal data analysis; Imaging generics structural equation modeling)
- Interpret results
- Write about statistical methods and results
For further information about the core services, please read:
To request, please visit the following link: Biostatistics Service Request Form
Please review the general Core Use Policy.
This facility utilizes CoreConnect, a web-based core management system that supports the centralization of services and equipment scheduling, billing and usage tracking. Use of the new system is required for all core users, core leaders and core staff.
Learn more about CoreConnect
This Core participates in the CHLA Core Pilot Program. To learn more click here.
CHLA welcomes external users to utilize our Biostatistics Core. If interested, please first complete the Biostatistics Service Request Form, and someone will be in touch within two business days.
The following information and internal prices are for Principal Investigators at CHLA and USC; rates are subject to change in the future.
The Biostatistics and Data Management Core is a charge-back service, with an initial free one-hour consultation. The Core will also provide a set number of hours of free service determined by an individual investigator’s needs and status. Once these hours have been used, the investigator has the option to purchase additional services on a recharge basis.
Complimentary Consultation Services (Does not apply to the Core Pilot Program)
|Initial Consultation: Up to 1 hour||Subsidized for any project based at CHLA|
|Junior Investigator: Up to 5 hours/year||Faculty who are within the first three years of their appointment as an Assistant Professor as well as any recipient of an intramural RCDA award.|
|Graduate Medical Education|
Up to 3 hours/year; two years maximum
Up to 5 hours/year; two years maximum
|Graduate Students within 2 years|
|Post-Doctoral, Clinical Training Fellows|
Up to 5 hours/year; two years maximum
|Post-Doctoral, Clinical Training Fellows|
|Career Development Scholars|
Up to 15 hours/year
|Defined as K-awardees as well as CTSI KL2 awardees|
|Extramural Grant Planning|
Up to 3 hours/year for fellowship and private foundation grants
|Researchers who are preparing a grant for submission within 6 months. This includes consultation and written text on issues related to:|
*Our top priority is to support NIH-funded, junior investigators and those applying for NIH funding.
*Annual maximum is 15 hours of consultation (for all projects combined)
*Unused hours per category cannot rollover to the next year and/or project
*This Core participates in the Core Pilot Program. The program exists to supply funding support for investigators to work on studies and acquire data for extramural applications. The Core offers two types of pilot funding: a traditional pilot grant (for up to 25 hours of biostatistics support) or a grant proposal pilot (for up to 12-15 hours of grant proposal writing/analysis), which requires the PI to include a minimum 10% effort for the faculty director in their proposal. For more information, click here.
Fee Based Service
|Any consultation or work performed after the initial consultation or outside of the complimentary services above will be charged $125/hr.||Open to all projects|
|Biostatistician % Effort|
There is an option to contract Core services for your on-going projects, center, or institute via percent effort support (minimum of 10%) of biostatisticians’ time instead of an hourly recharge, upon approval by TSRI leadership.
|Open to all projects, except for those awarded by the Core Pilot Program|
Core Reagent Inventory
Select Cores offer reagents as part of their purchasable services to the CHLA research community. A searchable Core Reagent Inventory was created in support of the CHLA research community BenchResearchHelp initiative that connects researchers with reagents when in need of a small amount of a reagent, such as an antibody, to determine the efficacy in a particular experiment.
CHLA based investigators are welcomed to browse the Cores Reagent Inventory to access the complete product list for pricing and availability. The database will be updated on an annual basis. Contact the Core for more information.
Core Acknowledgment in Publications
How to cite the Core in publications:
This work was supported by the Biostatistics and Data Management Core at The Saban Research Institute, Children's Hospital Los Angeles and by grants UL1TR001855 and UL1TR000130 from the National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Recent publications include:
James L, Menteer J, Moss LC, Durazo-Arvizu R, Wood JC, Ramos-Platt L, Tiongson E, Su JA. Early-Onset Late Gadolinium Enhancement is a Prognostic Factor for Duchenne Cardiomyopathy. Pediatr Cardiol. 2022 Sep 3. doi: 10.1007/s00246-022-02989-8. Online ahead of print. PMID: 36056946
Weisert M, Menteer J, Durazo-Arvizu R, Wood J, Su J. Early prediction of failure to progress in single ventricle palliation: A step toward personalizing care for severe congenital heart disease. J Heart Lung Transplant. 2022 Sep;41(9):1268-1276. doi: 10.1016/j.healun.2022.06.002. Epub 2022 Jun 6. PMID: 35778260
Khalighi M, Wheeler AP, Adeyemi-Fowode OA, Kouides PA, Durazo-Arvizu RA, Haley K, Dersch CM, Weyand AC, Baldwin MK, Borzutzky C. Does a Bleeding Disorder Lessen the Efficacy of the 52-mg Levonorgestrel-Releasing Intrauterine System for Heavy Menstrual Bleeding in Adolescents? A Retrospective Multicenter Study. J Adolesc Health. 2022 Aug;71(2):204-209. doi: 10.1016/j.jadohealth.2022.02.018. Epub 2022 Apr 13. PMID: 35430143
Naguib MN, Hegedus E, Raymond JK, Goran MI, Salvy SJ, Wee CP, Durazo-Arvizu R, Moss L, Vidmar AP. Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs. Front Endocrinol (Lausanne). 2022 Feb 25;13:841838. doi: 10.3389/fendo.2022.841838. eCollection 2022. PMID: 35282464 Free PMC article. Clinical Trial.
Maloney MA, Ward SLD, Su JA, Durazo-Arvizu RA, Breunig JM, Okpara DU, Gillett ES. Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea. J Clin Sleep Med. 2022 Jun 1;18(6):1629-1637. doi: 10.5664/jcsm.9944. PMID: 35212261
Santoro JD, Lee S, Wang AC, Ho E, Nagesh D, Khoshnood M, Tanna R, Durazo-Arvizu RA, Manning MA, Skotko BG, Steinberg GK, Rafii MS. Increased Autoimmunity in Individuals With Down Syndrome and Moyamoya Disease. Front Neurol. 2021 Sep 8;12:724969. doi: 10.3389/fneur.2021.724969. eCollection 2021. PMID: 34566869 Free PMC article.
Jung, K., Cho, S. S., Lee, J., & Ryoo, J. H. (in press). An illustrative application of generalized structured component analysis for brain connectivity research. Behaviormetrika. https://doi.org/10.1007/s41237-019-00080-w
Pullen, P. C., Ashworth, K. E., & Ryoo, J. H. (in press). Prevalence rates of students identified for special education and their interstate variability: A longitudinal approach. Learning Disability Quarterly. https://doi.org/10.1177/0731948719837912
Pas, E. T., Ryoo, J. H., Musci, R., & Bradshaw, C. (2019). The effects of a state-wide scale-up of school-wide positive behavior intervention and supports on behavioral and academic outcomes: A quasi-experimental examination. Journal of School Psychology, 73, 41-55. https://doi.org/10.1016/j.jsp.2019.03.001
Vidmar AP, Salvy SJ, Pretlow R, Mittleman SD, Wee CP, Fink C, Steven Fox D, Raymond JK. An addiction-based mobile health weight loss intervention: protocol of a randomized controlled trial. Contemp Clin Trials. 2019 Mar; 78:11-19. doi: 10.1016/j.cct.2019.01.008. Epub 2019 Jan 14. PMID:30654026
Vidmar AP, Fink C, Torres B, Manzanarez B, Mittleman SD, Wee CP and Borzutzky C. Energy Mangement for Personalized Weight Reduction (EMPOWER) Program: Three-Year Outcome Data. Gratis: Advances in Clinical Endocrinology and Metabolism. Published: March 10, 2019.
Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittleman SD. An addiction model-based mobile health weight loss intervention in adolescents with obesity. Pediatr Obes. 2019 Feb;14(2):e12464. doi: 10.1111/ijpo.12464. Epub 2018 Aug 16. PMID: 30117309
Lee, M., Ryoo, J. H., Chung, M., Anderson, J. G., Rose, K. M., & Williams, I. C. (in press). Effective interventions for depressive symptoms among caregivers of people with dementia: A systematic review and Meta-Analysis. Dementia: International Journal of Social Research and Practice. https://doi.org/10.1177/1471301218822640
Roberta M. Kato, Yoon-Chul Kim, Biswas Joshi, Shirleen Loloyan, Choo Phei Wee, Ziyue Wu, Winston H. Tran, Thomas G. Keens, Michael C. K. Khoo, Krishna S. Nayak, and Sally L. Davidson Ward. Upper Airway Narrowing during Central Apnea in Obese Adolescents. Ann Am Thorac Soc Vol 15, No 12, pp 1465–1471, Dec 2018. PMID: 30371114
Julie Jaffray, Lisa Baumann Kreuziger, Brian Branchford, Choo Phei Wee, E Vincent S Faustino, Neil A. Zakai,Stacy E. Croteau, Michael Silvey, John H. Fargo, James D. Cooper, Nihal Bakeer, Amy Stillings, Emily Krava, Guy Young, Neil A. Goldenberg. Symptomatic Pulmonary Embolus after Catheter Removal in Children with Catheter Related Thrombosis: A Report from the CHAT Consortium. 08 October 2021 https://doi.org/10.1111/jth.15548