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Matthew Borzage is a faculty researcher at the Children’s Hospital of Los Angeles with an interest in the area of neurodevelopment and a focus on flow of cerebrospinal fluid and blood in the brain. He is an assistant professor of research pediatrics at the University of Southern California Keck School of Medicine where he completed his doctoral thesis in biomedical engineering, with a focus on noninvasive methods of for assessing the developing brain.
MS, Biomedical Engineering, University of Southern California, Los Angeles, CA
PhD, Biomedical Engineering, University of Southern California, Los Angeles, CA
Pediatric Academic Society
American Society of Functional Neuroradiography, 2010-Present
American Society of Functional Neuroradiography
Tau Beta Pi
Magnetic resonance imaging
Hydrocephalus and cerebrospinal fluid flow
Cerebral hemodynamics and development
Empirical model of human blood transverse relaxation at 3 T improves MRI T2 oximetry. Bush A, Borzage M, Detterich J, Kato RM, Meiselman HJ, Coates T, Wood JC. Magnetic Resonance in Medicine. 2016 Jul 6. doi: 10.1002/mrm.26311. [Epub ahead of print]
Determinants of resting cerebral blood flow in sickle cell disease. Bush AM, Borzage MT, Choi S, Václavů L, Tamrazi B, Nederveen AJ, Coates TD, Wood JC. American Journal of Hematology. 2016 Sep;91(9):912-7. doi: 10.1002/ajh.24441. Epub 2016 Jul 4.
Predictors of cerebral blood flow in patients with and without anemia. Borzage MT, Bush AM, Choi S, Nederveen AJ, Václavů L, Coates TD, Wood JC. Journal of Applied Physiology (1985). 2016 Apr 15;120(8):976-81. doi: 10.1152/japplphysiol.00994.2015. Epub 2016 Jan 21.
Equations to describe brain size across the continuum of human lifespan. Borzage M, Blüml S, Seri I.Brain Structure & Function. 2014 Jan;219(1):141-50. doi: 10.1007/s00429-012-0490-6. Epub 2012 Dec 14.
Neonatal hemodynamics: monitoring, data acquisition and analysis. Soleymani S, Borzage M, Noori S, Seri I. Expert Review of Medical Devices. 2012 Sep;9(5):501-11. doi: 10.1586/erd.12.32. Review.
Development of non-invasive monitoring techniques for evaluating biological flow (blood, serum and cerebrospinal fluid), and evaluating neonatal brain development. Specific interests in MR-based methods for evaluating blood flow (Phase-Contrast MRI), and for evaluating CSF flow (Arterial Spin Labeling Variants).
Cerebral Blood Flow Response to Hyperoxia and Hypoxia in Patients with Sickle Cell Disease.
Comparison of Impediance Cardiography and MRI methods for Cardiac Output Measurement.
Monitoring CSF via TimeSLIP MRI methods in patients with neurosurgical indications of abnormal flow.
Hydrocephalus, Cerebral Blood Flow, Ventricular Morphology
Dr. Borzage’s primary training as a biomedical engineer enables him to work with the critical technologies of noninvasive data acquisition of cerebrospinal fluid and blood in the brain – specifically MR imaging and near infrared spectroscopy - with classic analysis techniques for these technologies and to have a critical working knowledge of the nature of the pathophysiologies that commonly impact flow in the brain, including disrupted CSF flow via Chiari malformations, spina bifida, post intraventricular hemorrhagic hydrocephalus, and disruptions of cerebral blood flow via anemia, specifically sickle- cell disease and other hemoglobinopathies. Combining his research interests and capabilities enables understanding the physiology that underlies some of the most devastating neurological pathologies.
Rudi Schulte Research Institute: Co-PI Evaluate a multi-modal imaging evaluation integrated with clinical workflow to improve the sensitivity and specificity of workup for shunt-responsive hydrocephalus.
Rudi Schulte Research Institute: Co-I Visualization of CSF movement throughout the central nervous system.
CSF Evaluate a multi-modal imaging evaluation integrated with clinical workflow to improve the sensitivity and specificity of workup for shunt-responsive hydrocephalus.
Individual Cerebral Hemodynamics and Oxygenation Relationship, where I am deploying the routine acquisition of developmental biomarkers useful in the neuro-focused clinical care and research of neonatal patients.