Grand Rounds 2017: “Gastrointestinal Stromal Tumors (GIST) in Pediatrics-Molecular Characterization and Management Principles”

At the end of this CME activity participants should be able to:

1. Identify the major clinical and genetic differences between pediatric-type GISTA and adult GIST
2. Identify the 2 major genetic mechanisms that lead to SDH-deficient (dSDH) GIST tumors in children
3. Describe the consequences of SDH-deficiency in GIST and general management principles

Lee J. Helman, MD
Head, Basic and Translational Research
Children's Center for Cancer and Blood Diseases
Director, Cancer and Blood Diseases Research Program
The Saban Research Institute
Children's Hospital Los Angeles
Professor, Departments of Pediatrics and Medicine
Keck School of Medicine
University of Southern California

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