A Pioneering Transplant Turns Ruben’s Heart Around (Literally)

Published on 
February 22, 2019
Categories: 

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By Katie Sweeney

The new heart was on its way down from the helipad.

At the same time, Cynthia Herrington, MD, was carefully removing Ruben’s old heart from his chest. It was a heart she had seen before—she had operated on it when Ruben, now 2, was just a few days old.

chla-ruben-brother.jpg She knew every inch of it: the missing left ventricle, the pulmonary arteries she had previously patched together, the leaky atrioventricular valve that had caused so much trouble, and the superior and inferior vena cava veins that were reversed—with both on the left side, rather than the right.

And of course, she also knew that Ruben’s entire heart was actually completely backwards in his chest. Yes, backwards.

In other words, this would not be a typical heart transplant. In fact, it would be the first-ever dextrocardia (backwards heart) transplant at Children’s Hospital Los Angeles—and one of the most complex surgeries of Dr. Herrington’s 20-year career as a congenital cardiothoracic surgeon.     

So, was she worried? Not a chance.     

“I tell my trainees all the time, ‘You don’t get to complain about complex anatomy,’” says Dr. Herrington, Surgical Director of the Heart Transplant Program at CHLA. “Because that’s what we do. This is what we thrive on here.”

‘So many strikes against him’     

The day before his transplant—on a hot August Sunday afternoon in the San Fernando Valley—Ruben had been at home, playing with his 6-year-old brother, Aidan.     

Up until the moment when his mom’s phone rang, it had been a normal day. At least, as normal as things had been since Ruben was born in April 2016. From birth, his heart had struggled valiantly to keep him alive.  

“He had hypoplastic left heart syndrome (HLHS), dextrocardia, heterotaxy syndrome, pulmonary atresia, discontinuous pulmonary arteries and atrioventricular valve regurgitation,” recounts his mom, Lily, running down the list from memory. “What else did he have? Oh yeah, he was born without a spleen.”

He underwent his first open-heart surgery at CHLA when he was just a few days old. Dr. Herrington performed the procedure, called the Norwood, which is the first of a series of three surgeries used to reconstruct the hearts of babies born with HLHS (a condition where the left ventricle, or pumping chamber, is missing). At the same time, she also patched together his pulmonary arteries.

But because of Ruben’s many other defects—especially that copiously leaking valve—he continued to struggle.

“He had so many strikes against him,” says Sarah Badran, MD, one of Ruben’s cardiologists at CHLA. “He had all the risk factors that put the chances of survival at less than 30 percent.”

But while the odds were against him, Ruben had other, more important things on his side. Like people—the dedicated, highly skilled team at CHLA that fought for him every step of the way and was uniquely positioned to treat his extremely complex case; his devoted parents, Lily and Carlos; his big brother who always protected him; and his whole extended family.

There was also his own unflaggingly happy nature.

“He is just the sweetest!” Dr. Badran says. “You cannot make him sad, this kid. He’d be having trouble breathing, and he’d have this big goofy smile and be trying to make you laugh.”

Big news

By 3 months of age, Ruben was back in the hospital at CHLA, in severe heart failure. At that point, he was too unstable for the team to consider a transplant. Time appeared to be running out.

Fortunately, despite Ruben’s fragile condition, Heart Institute Co-Director Vaughn Starnes, MD, was able to complete the second HLHS surgery for Ruben (called the Glenn). At the same time, he managed to partially repair Ruben’s troublesome valve, which had been barely functioning.

chla-ruben-dad.jpgIt was a lifesaving fix that bought Ruben precious time, and slowly, he recovered and went home. But it wasn’t a permanent solution, and eventually, the valve began leaking again.

His only hope now was a transplant. In March 2018, he was put on the waiting list for a heart. Because he was relatively stable, he was able to be at home instead of the hospital.

Now, everyone just had to wait—and hope he received a matching heart in time.

So on that hot afternoon of Aug. 19, 2018, when Lily got the call that a heart was available for Ruben, she knew it was excellent news. Still, she found herself overwhelmed with another emotion: fear.

At that moment, it pained her to have to interrupt Ruben’s happy playtime, gather his things and buckle him in the car—knowing full well he was headed into the biggest, most complicated and most dangerous surgery of his life.

“Just thinking about handing him over again, not knowing if he would be returned to me …” Her voice trails off. “That was an emotional day. Definitely.”

At 7 p.m. the next night, she and Carlos watched as their son was wheeled away into surgery. Then, they settled in for the long wait ahead.

A patchwork ‘quilt’     

Before she could even begin to connect Ruben’s new heart, Dr. Herrington and the CHLA surgical team had to create a delicate patchwork “quilt” of new connections for him.     

There was a lot to be done. “I had to be a little creative,” Dr. Herrington acknowledges. “But it’s basic principles of surgery. Nothing can be kinked or bent or stretched. We have techniques to make this happen.” 

To build new connections and vessels for Ruben, she first needed raw material. At her request, the donor’s surgical team had brought back not just the new heart, but also the donor’s entire innominate vein (a main artery) and the pericardial sac that the heart sits in.

Using these pieces, along with something called homograft (human cardiac tissue from deceased donors), she and the surgical team went to work—meticulously detaching vessels and arteries connected in the wrong places, patching up those holes, creating hoods of tissue to bridge gaps, attaching the vessels to the right places, arranging everything neatly, and finally, tucking the donor heart comfortably into its new home.

“It was all doable,” says Dr. Herrington, who had performed one other dextrocardia transplant earlier in her career. “We just took the steps and walked through.”  

Dr. Badran, who watched much of the surgery, describes it differently. “It was a massive reconstruction to fit a normal-shaped heart in a backwards space,” she says. “The way she brought the liver and inferior vena cava veins over, the amount of extensions she had to use to make things connect and not be twisted—it was amazing. I don’t know of a lot of surgeons who could have done that.”

Around 12:30 a.m.—five-and-a-half hours after Lily and Carlos had watched Ruben get wheeled into surgery—they saw Dr. Herrington walking toward them in her scrubs.

The surgery had gone fantastically. Ruben’s new heart was in.

‘There’s no stopping him’     

Today, Ruben is almost 3. He loves nerf guns and motorcycles, splashing in rain puddles, hugging babies (yes, you read that right) and roughhousing with Aidan—often leaping on top of his brother when he’s lying on the sofa. He is constantly running around the house.

“There’s no stopping him,” says his mom. “He’s all over the place!”

chla-ruben-baby.jpgThat said, his recovery from surgery was by no means easy. He was on a ventilator for 17 days, was briefly in kidney failure, and at first, he wasn’t walking or talking or even smiling anymore. His medications had to be adjusted, and Dr. Badran eventually had to put stents into his pulmonary veins to allow the blood to drain better.

But Ruben, in true Ruben fashion, persevered. Today, while he takes many medicines and has regular speech, physical and occupational therapy, he is doing great.

Dr. Herrington hopes that parents of other children who have complex conditions like dextrocardia will take a message of hope from Ruben’s story. “We can offer transplant for kids with really complicated anatomy,” she says. “It’s possible. I want families to understand that.”

She also stresses that Ruben’s success was made possible by the whole Heart Institute team at CHLA—from anesthesiologists to cardiologists to critical care nurses and more. “You cannot find this team anywhere in the United States. I believe that entirely,” Dr. Herrington adds.

Lily, meanwhile, wants to say thank you—to the family who donated Ruben’s new heart, to Dr. Herrington and the surgical team, to Dr. Badran and all the doctors and nurses at CHLA who have been involved in Ruben’s care.

“They saved my son’s life,” she says. “I’m just thankful. I’m forever thankful.”

How you can help

To give kids just like Ruben a healthier future, please consider making a donation to Children's Hospital Los Angeles. Visit CHLA.org/Donate.