Cerebrovascular Integrity in Fontan Patients
The objective of this study is to better understand how a single ventricular heart with Fontan physiology may affect brain health.
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Fetal Substudy (Congenital Heart Disease & Control)
Develop better ways of screening and diagnosing certain types of brain injuries in infants and children who are born with and without congenital heart disease.
MR Imaging of Perinatal Brain Injury
The collection of the research data we hope will help better screening, diagnosing procedures and treatment of brain injury in newborns and identify a connection between MR imaging and neurodevelopmental outcomes.
Non-Invasive Screening for Cerebrovascular Disease in Down Syndrome
To investigate if non-invasive screening for cerebrovascular diseases in persons with Down syndrome is feasible with the goal of preventing stroke.
Remodulin for the treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN)
To explore the safety and treatment effect of intravenous (IV) Remodulin as add on therapy in neonates with PPHN compared to placebo.
Safety of UCB-MNC Delivered into the Myocardium in HLHS Subjects
To determine the safety and feasibility of autologous umbilical cord blood-derived mononuclear cells delivered into the myocardium of the right ventricle during planned Stage II Glen surgical procedure for individuals with hypoplastic left heart syndrome.
Vascular Function in Children
The objective of this study is to better understand the effects of chronic diseases, such as congenital heart disease, on blood vessel function and on blood characteristics.
Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility Study
To assess the survival rate of subjects at 6 and 12 months following implantation of the Bioabsorbable pulmonary valve conduit. To assess the rate of conduit failures at 6 months, requiring re-intervention or reoperation.