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Extubation failure in newborn infants

Validate the use of respiratory inductance plethysmography (RIP) and esophageal manometry in diagnosing upper airway obstruction (UAO) in newborn infants.

Healthy Development

Determine how potentially stressful situations, including prematurity, hospitalizations, maternal mental health and rapid repeat births can impact a baby’s development in the first 12 months of their life.

HIGH DOSE ERYTHROPOIETIN FOR ASPHYXIA AND ENCEPHALOPATHY (HEAL)

1) To determine if 5 doses of Epo (Erythropoietin) 1000 U/kg (birth weight) intravenous (IV) reduces the rate of death or neurodevelopmental impairment (mild, moderate, or severe) at 24 months of age. 

2) To assess safety of Epo. 

3) To determine whether Epo decreases the severity of HIE-induced brain injury as evidenced by early MRI and plasma biomarkers of brain injury.