A Placebo-controlled study of Maralixibat in Subjects with Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC)
To find out the effects of Maralixibat on the treatment of PFIC.
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Fecal Microbiota Transplantation (FMT) in Crohn's disease
Safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease in remission.
Fecal Microbiota Transplantation (FMT) in Ulcerative Colitis
To know if stool transplant from a healthy person into an ulcerative colitis patient can help treat the disease.
Pragmatic Pediatric Trial of Balanced vs. Normal Saline Fluid in Sepsis (PRoMPT BOLUS)
To find out which of two commonly used IV fluids given in the Emergency Department for sepsis is most effective.
ProMetic BioTherapeutics Immune Globulin Intravenous (PBT IVIG Protocol 2004C009G)
Two main purposes of the study: To see if serious bacterial infections occur less than once a year in each study subject. This will determine if study drug is effective. Also to find out if study drug is safe and tolerable for study subjects.
Tenofovir Alafenamide (TAF) in Adolescents with Chronic Hepatitis B Virus Infection (GS-US-320-1092)
To find out the effects of tenofovir alafenamide (TAF) on children and adolescents with chronic hepatitis B.
Tofacitinib in Children with Ulcerative Colitis (Pfizer OVATION Protocol A3921210)
To evaluate the efficacy of tofacitinib based on remission in pediatric participants with moderately to severely active Ulcerative Colitis (UC).