Stefano Da Sacco, PhD, earned his PhD in tissue engineering in a joint effort from the University of Padua (Italy) and from the University of Southern California and completed his post-graduate training in the laboratory of Roger De Filippo, MD, FACS, FAAP and Laura Perin, PhD. His research has focused on the relationship between extracellular matrix and self-renewal, differentiation and specification of nephron progenitors. Da Sacco is an assistant professsor of urology with the University of Southern California.
2006 -2009 PhD, Tissue Engineering and Stem Cells, University of Southern California and University of Padova, Padova, Italy
2005 MS, Pharmaceutical Chemistry and Drug Design, University of Padova, Padova Italy
2009 – 2014 Post-doctoral Research Fellow, Urology, USC, Children’s Hospital Los Angeles
2014 – 2016 Post-doctoral Research Associate, Urology, USC, Children’s Hospital Los Angeles
2011 – Present American Society of Nephrology – Active Member
2011 – 2012 International Society for Stem Cell Research – Active Member
2010- Present ISSNAF – Supporting member
2015- Present American Heart Association - Member
The Saban Research Institute Research Career Development Award 2017-2019
Title Development and Characterization of a Glomerulus-on-a-chip Platform for Disease modeling and Drug Screening
Wright Foundation Pilot Award 2017-2018
Title Reducing Cardiovascular Disease by Protecting the Kidney: The Development of a Novel Glomerulus-on-a-Chip Platform for Drug Screening
SC CTSI Pilot Funding Award 2014 - 2015
Title: Podocyte progenitors derived from human amniotic fluid: applications for drug screening
ASF, Maquarie, Pedersen Family, KFOC Alport Syndrome Research 2014 - 2015
Title: Podocyte response to injury in Alport Syndrome: an answer from human amniotic fluid kidney progenitors
CIRM Stem Cell Training Grant 2011 - 2014
Title: Rebuilding a Glomerular Barrier with Podocyte Progenitors from Amniotic Fluid
Role: Post-Doctoral Fellow
Da Sacco S, Thornton ME, Petrosyan A, Lavarreda-Pearce M, Sedrakyan S, Grubbs BH, De Filippo RE, Perin L. Direct Isolation and Characterization of Human Nephron Progenitors. Stem Cells Translational Medicine. 2017 Feb;6(2):419-433. doi: 10.5966/sctm.2015-0429. Epub 2016 Sep 9.
Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. A novel source of cultured podocytes. PLoS One. 2013 Dec 12;8(12):e81812. doi: 10.1371/journal.pone.0081812. eCollection 2013.
Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. Journal of Urology. 2010 Mar;183(3):1193-200. doi: 10.1016/j.juro.2009.11.006. Epub 2010 Jan 22.
Da Sacco S, De Filippo RE, Perin L. Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration. Current Opinion in Organ Transplantation. 2011 Feb;16(1):101-5. doi: 10.1097/MOT.0b013e3283424f6e. Review.
Perin L, Giuliani S, Sedrakyan S, DA Sacco S, De Filippo RE. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatric Research. 2008 May;63(5):467-71. doi: 10.1203/PDR.0b013e3181660653. Review.
- Relation between extracellular matrix and self-renewal, differentiation and specification of nephron progenitors
- Development of a Glomerulus-on-a-chip as a tool to study disease modeling and drug toxicity