Publications
Publications are up to date at https://profiles.scctsi.org/tamara.simon
CLIMB
Pandey S, Whitlock KB, Test MR, Hodor P, Pope CE, Limbrick DD Jr, McDonald PJ, Hauptman JS, Hoffman LR, Simon TD; Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group. Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus. PLoS One. 2023 Jun 21;18(6):e0280682. doi: 10.1371/journal.pone.0280682. PMID: 37342995; PMCID: PMC10284395.
Simon TD, Sedano S, Rosenberg-Hasson Y, Durazo-Arvizu R, Whitlock KB, Hodor P, Hauptman JS, Limbrick DD, McDonald P, Ojemann JG, Maecker HT; Cerebrospinal FLuId MicroBiota in Shunts CLIMB Study Group. Lower levels of Th1 and Th2 cytokines in cerebrospinal fluid (CSF) at the time of initial CSF shunt placement in children are associated with subsequent shunt revision surgeries. Cytokine. 2023 Sep;169:156310. doi: 10.1016/j.cyto.2023.156310. Epub 2023 Jul 29. PMID: 37523803.
Pope CE, Whitlock KB, Hodor P, Limbrick DD Jr, McDonald PJ, Hauptman J, Hoffman LR, Simon TD. A Refined, Controlled 16S rRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis. Microbiol Spectr. 2023 Jun 15;11(3):e0036123. doi: 10.1128/spectrum.00361-23. Epub 2023 May 4. PMID: 37140368; PMCID: PMC10269467.
Simon TD, Schaffzin JK, Stevenson CB, Willebrand K, Parsek M, Hoffman LR. Cerebrospinal fluid shunt infection: Emerging paradigms in pathogenesis that affect prevention and treatment. J Pediatr. 2019 Mar;206:13-19. doi: 10.1016/j.jpeds.2018.11.026. Epub 2018 Dec 6. PMID: 30528757; PMCID: PMC6389391.
Hodor P, Pope CE, Whitlock KB, Hoffman LR, Limbrick DL, McDonald PJ, Hauptman JS, Ojemann JG, Simon TD. Molecular characterization of microbiota in cerebrospinal fluid from patients with CSF shunt infections using whole genome amplification followed by shotgun sequencing. Front Cell Infect Microbiol. 2021 Aug 20;11:699506. doi: 10.3389/fcimb.2021.699506. PMID: 34490140; PMCID: PMC8417900.
Whitlock KB, Pope CE, Hodor P, Hoffman LR, Limbrick DL Jr, McDonald PJ, Hauptman JS, Ojemann JG, Simon TD; Cerebrospinal fLuId MicroBiota in Shunts Study (CLIMB) Group. Characterization of cerebrospinal fluid (CSF) microbiota from patients with CSF shunt infection and reinfection using high throughput sequencing of 16S ribosomal RNA genes. PLoS One. 2021 Jan 6;16(1):e0244643. doi: 10.1371/journal.pone.0244643. PMID: 33406142; PMCID: PMC7787469.
PHIS+ Shunt Infection Prevention
Sedano S, Kronman MP, Whitlock KB, Zhou C, Coffin SE, Hauptman JS, Heller E, Mangano FT, Pollack IF, Schaffzin JK, Thorell E, Warf BC, Simon TD. Associations of standard care, intrathecal antibiotics, and antibiotic impregnated catheters with cerebrospinal fluid shunt infection organisms and resistance. J Pediatric Infect Dis Soc. 2023 Sep 8:piad064. doi: 10.1093/jpids/piad064. Epub ahead of print. PMID: 37681670.