CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Study Details - ID: CHLA-20-00637
Health/Science/Disease Category:
Single Ventricle Congenital Heart Disease
Purpose of Research:
The objective of this study is to better understand how a single ventricular heart with Fontan physiology may affect brain health.
Short Name:
Cerebrovascular Integrity in Fontan Patients
Full Title of Study:
Cerebrovascular Integrity in Fontan Patients
Phase/Type of Study:
Males and females 13 years or older who have completed a Fontan procedure for single ventricle heart disease. Must not have had brain injury or trauma, or a history of extracorporeal support. Must not have documented genetic abnormality. Must not have dental braces, pacemaker, claustrophobia or be pregnant. Must be able to undergo about 1 hour of MRI without sedation.
Time Commitment/Requirements:
Participants will be scheduled for 1 MRI visit and 1 neurocognitive test visit, each visit lasting for about 3 hours.
Primary Investigator:
John C. Wood, MD, PhD
Coordinator Contact Name:
Silvie Suriany
Phone Number: