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To find out the effects of tenofovir alafenamide (TAF) on children and adolescents with chronic hepatitis B.

Carfilzomib (also known as Kyprolis®) is approved to be used in certain adult patients with relapsed or refractory multiple myeloma (myeloma that returns after a successful course of treatment or myeloma that does not respond to treatment). Multiple myeloma is a type of blood cancer. Carfilzomib is not approved to treat ALL. It has not been given in combination with the other drugs used in this study. This study is being done to find out if carfilzomib can be safely given before and during treatment with standard chemotherapy drugs.

The goals of this study are to improve survival rates in children and young adults with relapsed AML through the combination of DEC and VOR.

This study aims to evaluate the side effects (good and bad) of giving Vincristine Suflate Liposome Infection (also known as Marqibo®) - a drug approved for leukemia treatment in adults but that is experimental in children - with other standard chemotherapy drugs and to measure how effective the combination is at treating children and young adults with leukemia that has come back after initial treatment.

To find out if Time Limited Eating can help teens lose weight.

Intervention Study for Type 2 Diabetes.

To evaluate the efficacy of tofacitinib based on remission in pediatric participants with moderately to severely active Ulcerative Colitis (UC).

The primary aim of this registry will be to identify genes and/or biologic and environmental factors that either cause these tumors or increase one's risk for developing them. Ultimately, research using this registry may result in improved diagnosis, more effective treatments and possibly prevention.

CD19 is a B-cell surface protein expressed throughout B cell development; therefore, it is expressed on nearly all B cell malignancies, including acute lymphoblastic leukemia (ALL),and many non-Hodgkin lymphomas. B cell neoplasms are clonal tumors of mature and immature B lymphocytes (e.g., acute lymphoblastic leukemia).UCART19 is intended to treat CD19-positive B lymphoid malignancies in paediatric and adult populations.

The objective of this study is to better understand the effects of chronic diseases, such as congenital heart disease, on blood vessel function and on blood characteristics.