CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Study Details - ID: CHLA-16-00523
Health/Science/Disease Category:
Healthy Adults Planning to Receive the Ty21a Typhoid Vaccine
Purpose of Research:
We are studying the role of gut microbiome diversity on the mucosal and systemic responses to Ty21a vaccine. This is to determine if a given microbiota composition is associated with specific immune responses and to evaluate the impact of an oral typhoid vaccination on the human gut microbiota.
Short Name:
Gut microbiome and response to oral typhoid vaccine
Full Title of Study:
Impact of the gut microbiome on response to oral typhoid vaccine in healthy adults
Phase/Type of Study:
Healthy individuals 18 years of age and older who are planning to receive Ty21a vaccine
Time Commitment/Requirements:
7 visits will be performed over 2 months. We will collect oral, stool and blood samples. Participants will not be paid for participation. However, they will be reimbursed for the vaccine cost upon study completion.
Primary Investigator:
Dr. Pia Pannaraj
Coordinator Contact Name:
Phone Number:
Clinical Trials .Gov Identifier: