Medical Director of Pancreas Clinic
Attending Physician
Clinical Assistant Professor of Pediatrics (Clinician Educator), Keck School of Medicine of USC
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Dr. Yuhua Zheng graduated from Peking University Health Science Center, School of Medicine. She also obtained her Master of Science degree from Peking University Health Science Center. After finishing her residency training in Pediatrics in Peking University First Hospital, Dr. Zheng came to University of California, San Francisco (UCSF) and conducted her basic science research as a research postdoctoral fellow on EDG signaling, a family of G-protein coupled receptors involved in wound healing. Dr. Zheng then finished her second residency training in Pediatrics in United States of America. She received her Pediatric gastroenterology fellowship training in Children’s Hospital Los Angeles (CHLA), Division of Gastroenterology, Hepatology and Nutrition, Keck School of Medicine (KSOM), University of Southern California (USC). She received her NIH K12 grant and focused her basic research on inflammatory bowel disease (IBD). Currently Dr. Zheng serves as the Medical Director of CHLA GI Pancreas Clinic.

Clinical Interests

Dr. Zheng focuses on taking care of patients with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) along with other pancreas disorders. Dr. Zheng is also interested in research on understanding inflammatory bowel disease (IBD).

Education

Medical School: 

Peking University Health Science Center, School of Medicine

Internship: 

Peking University First Hospital

White Memorial Medical Center

Residency: 

Peking University First Hospital

White Memorial Medical Center

Fellowship: 

Children’s Hospital Los Angeles - Pediatric Gastroenterology

Accomplishments

Certification: 

Pediatric Gastroenterology - American Board of Pediatrics

General Pediatrics - American Board of Pediatrics

Professional Memberships: 

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)

American Gastroenterological Association (AGA)

Active Committee Member of Inflammatory Bowel Disease Committee of NASPGHAN

International Association of Pancreatology

Awards: 

NIH K12 
NIH NIDDK UO1 

Other Information

Specialty Interest: 

1. Pancreas disorders:

  • Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP)
  • Autoimmune pancreatitis. This chronic inflammation is likely
  • Annular pancreas
  • Pancreas divisum
  • Pancreatic cysts and pseudocysts
  • Pancreatic tumors
  • Pancreatic exocrine insufficiency
  • Pancreatic trauma

2. Inflammatory Bowel Disease

3. Pediatric Gastroenterolgy

Publications: 

Aliye Uc, Emily R. Perito, John F. Pohl, Uzma Shah, Maisam Abu-El-Haija, .., Yuhua Zeng, ...Mark E. Lowe. International Study Group of Pediatric Pancreatitis: In Search for A Cure (INSPPIRE2) Cohort Study in Consortium for the Study of chronic Pancreatitis, Diabetes and Pancreatic Cancer’s (CPDPC): Design and Rationale Pancreas 2018 Nov 

Yuhua Zheng, Sonia Michail. EBV Status and Thiopurine Use in Children With Inflammatory Bowel Disease (Expert Comment) Practice Update 2016 June

Tony W.H. Li, Hui Peng, Heping Yang, Steven Kurniawidjaja, Parizad Panthaki, Yuhua Zheng, José M. Mato, and Shelly C. Lu. S-adenosylmethionine and Methylthioadenosine Inhibit Beta Catenin Signaling by Multiple Mechanisms in Liver and Colon Cancer Mol Pharmacol. 2015 Jan;87(1):77-86. Epub 2014 Oct 22. 

Heping Yang, Yuhua Zheng (co-first author) , Adriana Rojas, José M. Mato, and Shelly C. Lu. Role of Methionine Adenosyltransferase 2B in Resveratrol’s Biological Activities in Liver Cancer Cells J Biol Chem. 2013 Jun 28. 

H Peng, L Dara, T Li, Y Zheng, HYang, JM Mato, SC. Lu Methionine Adenosyltransferase 2B-GIT1 Interplay Activates MEK1-ERK1/2 to Induce Growth in Human Liver and Colon Cancer Hepatology. 2013 Jan 16. 

Zheng, Y; Kong, Y; Goetzl,E. Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrne. Journal of Immunology 166: 2317-2322, 2001 

Zheng Y, Voice J, Kong Y, Goetzl E. Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. FASEB Journal, 14 :2387-2389, 2000 

An S, Zheng Y and Bleu T. Sphingosine 1-phosphate-induced cell proliferation, survival and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biological Chemistry, 275:(1)288-296, 2000 

An S, Bleu T, Zheng Y. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. Molecular Pharmacology, 55:787-794, 1999 
An S, Zheng Y and Goetzl E. Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization. Molecular Pharmacology, 54:881-888, 1998 (9804623). 

Research Interests: 

Dr. Zheng's primary research interest is pediatrics pancreas disorders. Dr. Zheng is the site primary investigator in multiple international studies including: The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE and INSPPIRE2), Safety & Technical outcomes of ERCP in Pediatric Patients Performed by Adult vs Pediatric Gastroenterologists. Dr. Zheng was also the primary investigator in multiple multicenter, randomized, -blind, placebo-controlled studies of Anti-TNF agents used in inflammatory bowel disease.

Reasearch Topics

1. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE and INSPPIRE2)
2. Safety & Technical outcomes of ERCP in Pediatric Patients Performed by Adult vs Pediatric Gastroenterologists
3. Multiple multicenter, randomized, -blind, placebo-controlled studies of Anti-TNF agents used in inflammatory bowel disease.
4. Hepatitis B Antibody in Inflammatory Bowel Disease patients

Research Focus/Overview

To comprehensively characterize the pediatric population with Acute Recurrent Pancreatitis (ARP) and Chronic Pancreatitis (CP) and determine predictors of early onset CP and its sequelae.

Acute pancreatitis (AP) was once considered an uncommon disease of childhood. In recent years, the number of children with AP has increased to an annual incidence approaching that of adults. Despite modest incidence rates, ARP and CP are associated with significance disease burden. The risk factors that predispose children to recurrent attacks of AP, then progression from ARP to CP and finally to exocrine and endocrine pancreatic insufficiency are not known. Most of the existing information on diagnostic modalities and treatment options is derived from adult studies. Most studies on pediatric pancreatitis are retrospective. Therefore it is not possible to draw conclusions about pediatric ARP and CP from these studies. Also, the lack of patient data and understanding makes it impossible to design and implement therapeutic trials in children. Because ARP and CP are not common in pediatrics, prospective multicenter studies are crucial to address fundamental gaps in knowledge. There are no prospective studies, nor diagnostic and therapeutic guidelines in pediatric CP. The INSPPIRE Consortium was formed to systematically characterize ARP and CP in children and address the knowledge gap in pediatric pancreatitis. We plan to overcome these barriers using the collective expertise, data, and samples provided by all collaborating sites.

Study population and methodology: The study will enroll a total of 860 patients 0-18 y/o with ARP or CP over the next 4 years. Patient questionnaires and physician surveys will be applied at the time of enrollment and annually. We aim to define the demographics of the pediatric ARP and CP cohort, describe risk factors, presence of family history of acute and chronic pancreatitis, diabetes and pancreatic cancer and assess disease burden and sequelae.

Statistical considerations: Summary statistics and graphs will be used to characterize the pediatric population, disease course, and development of complications. Continuous variables will be summarized by mean, median, range, standard deviation and 95% confidence interval. Categorical variables will be summarized by frequency table and 95% confidence. All statistical analyses will be based on the combined data collected in this protocol and the previous protocol (i.e. INSPIRE 1) before the study team joined the CPDPC consortium.

Current Funding

NIH NIDDK subaward

Current Research Studies

1. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE and INSPPIRE2)
2. Safety & Technical outcomes of ERCP in Pediatric Patients Performed by Adult vs Pediatric Gastroenterologists
3. Multiple multicenter, randomized, -blind, placebo-controlled studies of Anti-TNF agents used in inflammatory bowel disease.
4. Hepatitis B Antibody in Inflammatory Bowel Disease patients

Children's Hospital Los Angeles

4650 Sunset Blvd.
MS #78
Los Angeles, CA 90027
Phone: 323-361-2181Office
Fax: 323-361-3718Fax