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Stefano Da Sacco, PhD
Investigator, Urology Research
Assistant Professor, University of Southern California
Stefano Da Sacco, PhD, earned his PhD in tissue engineering in a joint effort from the University of Padua (Italy) and from the University of Southern California and completed his post-graduate training in the laboratory of Roger De Filippo, MD, FACS, FAAP and Laura Perin, PhD. His research has focused on the relationship between extracellular matrix and self-renewal, differentiation and specification of nephron progenitors. Da Sacco is an assistant professsor of urology with the University of Southern California.
Education
Graduate School
2006 -2009 PhD, Tissue Engineering and Stem Cells, University of Southern California and University of Padova, Padova, Italy
2005 MS, Pharmaceutical Chemistry and Drug Design, University of Padova, Padova Italy
Fellowship
2009 – 2014 Post-doctoral Research Fellow, Urology, USC, Children’s Hospital Los Angeles
2014 – 2016 Post-doctoral Research Associate, Urology, USC, Children’s Hospital Los Angeles
Accomplishments
Memberships
2011 – Present American Society of Nephrology – Active Member
2011 – 2012 International Society for Stem Cell Research – Active Member
2010- Present ISSNAF – Supporting member
2015- Present American Heart Association - Member
Funding
The Saban Research Institute Research Career Development Award 2017-2019
Title Development and Characterization of a Glomerulus-on-a-chip Platform for Disease modeling and Drug Screening
Role: PI
Wright Foundation Pilot Award 2017-2018
Title Reducing Cardiovascular Disease by Protecting the Kidney: The Development of a Novel Glomerulus-on-a-Chip Platform for Drug Screening
Role: PI
SC CTSI Pilot Funding Award 2014 - 2015
Title: Podocyte progenitors derived from human amniotic fluid: applications for drug screening
Role: Co-PI
ASF, Maquarie, Pedersen Family, KFOC Alport Syndrome Research 2014 - 2015
Title: Podocyte response to injury in Alport Syndrome: an answer from human amniotic fluid kidney progenitors
Role: PI
CIRM Stem Cell Training Grant 2011 - 2014
Title: Rebuilding a Glomerular Barrier with Podocyte Progenitors from Amniotic Fluid
Role: Post-Doctoral Fellow
Publications
Publications
Da Sacco S, Thornton ME, Petrosyan A, Lavarreda-Pearce M, Sedrakyan S, Grubbs BH, De Filippo RE, Perin L. Direct Isolation and Characterization of Human Nephron Progenitors. Stem Cells Translational Medicine. 2017 Feb;6(2):419-433. doi: 10.5966/sctm.2015-0429. Epub 2016 Sep 9.
Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. A novel source of cultured podocytes. PLoS One. 2013 Dec 12;8(12):e81812. doi: 10.1371/journal.pone.0081812. eCollection 2013.
Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. Journal of Urology. 2010 Mar;183(3):1193-200. doi: 10.1016/j.juro.2009.11.006. Epub 2010 Jan 22.
Da Sacco S, De Filippo RE, Perin L. Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration. Current Opinion in Organ Transplantation. 2011 Feb;16(1):101-5. doi: 10.1097/MOT.0b013e3283424f6e. Review.
Perin L, Giuliani S, Sedrakyan S, DA Sacco S, De Filippo RE. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatric Research. 2008 May;63(5):467-71. doi: 10.1203/PDR.0b013e3181660653. Review.
PubMed Link
Research
Research Summary
- Relation between extracellular matrix and self-renewal, differentiation and specification of nephron progenitors
- Development of a Glomerulus-on-a-chip as a tool to study disease modeling and drug toxicity
Visit the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology
Los Angeles, CA 90027
United States