Pat Levitt, PhD

Chief Scientific Officer, Vice President and Director, The Saban Research Institute

Simms/Mann Chair in Developmental Neurogenetics

Children’s Hospital Los Angeles

W.M. Keck Provost Professor in Neurogenetics

Department of Pediatrics, Keck School of Medicine of USC

Visit Dr. Levitt's Lab page to learn more.

Dr. Levitt received his B.A. in Biology at the University of Chicago, a Ph.D. in Neuroscience at University of California, San Diego and a postdoctoral fellow at Yale University. Dr. Levitt has held chair and institute directorships at University of Pittsburgh Medical Center, Vanderbilt University and USC. Dr. Levitt has been a National Institute of Mental Health MERIT awardee, McKnight awardee, and has served as a member of the National Advisory Mental Health Council for the National Institute of Mental Health. He is an elected Fellow of the American Association for the Advancement of Science (AAAS) and an elected member of the National Academy of Medicine.

He is a Senior Fellow at the Center for the Developing Child at Harvard University, and serves as Scientific Director of the National Scientific Council on the Developing Child, a policy council that brings the best research from child development and neuroscience to assist state and federal policy makers and private sector business leaders in making decisions regarding child program investment.

His research program includes basic studies that probe the ways in which circuitries that controls learning, emotional and social behavior develop, using advanced technologies in genetics, cell biology and behavior. Clinical research investigates children with autism spectrum disorder who have co-occurring gastrointestinal and other conditions. Studies of infant resilience to adversity focus on the brain-based and metabolic changes that may have short and long-term impacts on mental and physical health. He has published over 275 scientific papers.

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Education

Graduate School

University of California, San Diego

Fellowship

Postdoctoral Fellow, Yale University School of Medicine

Accomplishments

Certification

BA, Biological Sciences, University of Chicago; PhD, Neurobiology, University of California, San Diego

Medical Awards

NIMH R01 “Function and Structure Adaptations in Forebrain Development”
Autism Speaks “Response Heterogeneity to GI Treatment, Autism Symptom and Improved Oxidative Stress”
NIH T32 “Training in Fundamental Neuroscience”
The Simms/Mann Family Foundation Discovery Research Fund
The Simms/Mann Family Foundation, High-Risk, High-Impact Exploratory Research and Next Generation Research Project Incubation
JPB Research Network on Toxic Stress: A Project of the Center on the Developing Child at Harvard University
Higgins Family Foundation “Pilot Clinical Trial on Autism and the Gut Microbiome

USC Bio Link

USC Biography

Publications

Bonnin, A., Goeden, N., Chen, K., Wilson, M.,L., King, J., Shih, J.C., Blakely, R.D., Deneris, E.S., Levitt, P. (2011) A transient placental source of serotonin for the fetal forebrain. Nature 472: 347-350.

Mukamel, Z., Konopka, G., Wexler, E., Osborn, G.E., Bergman, M.Y., Levitt, P., Geschwind, D.H. (2011) Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk. J. Neurosci. 31:11437-11442.

State, M.W., Levitt, P. (2011) The conundrums of understanding genetic risks for autism spectrum disorders. Nat. Neurosci. 14:1-8.

Qiu, S., Aldinger, K.A., Levitt, P. (2012) Modeling of Autism Genetic Variations in Mice. Focusing on Synaptic and Microcircuit Dysfunction. Dev. Neurosci. 34:88-100.

Rudie, J.D., L. M. Hernandez, L.M., Brown, J.A., Beck-Pancer, D., N. L. Colich, N.L., Gorrindo, Thompson, P.M., Geschwind, D.H., Bookheimer, S.Y., Levitt, P., Dapretto, M. (2012) Autism Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks. Neuron 75:904-915.

Gorrindo, P., Lane, C.J., Lee, E.B., McLaughlin, B.A., Levitt, P. (2013) Enrichment Of Elevated Plasma f_2t-Isoprostane Levels In Individuals With Autism Who Are Stratified By Presence of Gastrointestinal Dysfunction. PLoS One 8:e68444.

Plummer, J.T., Evgrafov, O.V., Bergman, M.Y., Friez, M., Haiman, C.A., Levitt, P., Aldinger, K.A. (2013)Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome. Transl. Psychiatry 3:e316.

Qiu, S. Lu, Z., Levitt, P. (2014) MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis and glutamatergic synapse formation in the hippocampus. J. Neurosci. 34:16166-16179, 2014.

Wang, F., Eagleson, K.L., Levitt, P. (2015) Positive regulation of neocortical synapse formation by Plexin-D1 receptor. Brain Research 1616:157-165.

Aldinger, K.A., Lane, C.J., Veenstra-VanderWeele, J., Levitt, P. (2015) Patterns of risk for multiple co-occurring medical conditions replicate across distinct cohorts of children with autism spectrum disorder. Autism Res., e-Ahead of Print.

Resources

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PubMed Link

Publications on PubMed

Research

Research Summary

The Levitt Laboratory is unique in undertaking both basic and clinical research projects. Research projects investigate the development of brain architecture that controls emotional and social behavior and learning, the challenges that arise when neurodevelopment is derailed, and determining why brain and certain medical disorders often co-occur in children and adolescents. Areas of focus include: development of neural circuitry; regulation of genes for neurodevelopment disorders; fetal brain development; clinical studies of children with ASD; and clinical neuroscience studies of resilience in very young children.

Learn more about the Levitt Laboratory.

Research Studies

Healthy Development

Determine how potentially stressful situations, including prematurity, hospitalizations, maternal mental health and rapid repeat births can impact a baby’s development in the first 12 months of their...

Biomedical and Behavioral Infant Screening

Learn more about healthy baby development and develop new tools for pediatricans so they can better support the unique development of each child.

HBCD

To understand how environmental factors affect a child's early brain development. This includes positive factors like social support and parent-child bonding and challenges like poverty, stress and...