• Summary
  • Publications
  • Research
  • Media
  • Locations

 

My current work involves the development of numerical tools for the analysis of brain structural and diffusion magnetic resonance imaging data. In particular, these include improvements to tensor-based morphometry, surface and volume registration, segmentation and statistics for group comparisons.

I also work on applying these methods to different types of brain imaging data including prematurity, healthy brain development, healthy twins, blindness, deafness, HIV/AIDS, autism and Alzheimer's disease. I am currently an assistant professor in Radiology at the University of Southern California and at Children's Hospital Los Angeles.

I graduated with a Bsc in physics and mathematics from the University of Montreal and then obtained a masters in applied mathematics from Cambridge University, in general relativity. My PhD is in theoretical physics (Harvard University), and deals with quantum chaos in quantum billiards living on the plane and the pseudosphere.

Afterward, I switched to neuroimaging and became a postdoctoral fellow at the Laboratory of Neuro Imaging, working with Dr Paul Thompson.

Publications: 

 

A Panigrahy, J Wisnowski, A Furtado, N Lepore, L Paquette, S Bluml Neuroimaging Biomarkers of Preterm Brain Injury: Toward Developing the Preterm Connectome, 2011

CC Brun, N Lepore, X Pennec, YY Chou, M Barysheva, AD Lee, GI de Zubicaray, K McMahon, M Wright, AW Toga, PM Thompson: A Non-Conservative Lagrangian Framework for Statistical Fluid Registration, A Non-Conservative Lagrangian Framework for Statistical Fluid Registration, 2011

AD Lee, N Lepore, M Barysheva, YY Chou, A Schwartzman, CC Brun, SK Madsen, GI de Zubicaray, K McMahon, M Wright, AW Toga, PM Thompson: A multivariate analysis of the eect of genes and environmenton brain fiber architecture, 2011

LC Henry, J Tremblay, S Tremblay, AD Lee, C Brun, N Lepore, M Lassonde: Acute and Chronic Changes in Diffusivity Measures After Sports Concussions, Journal of Neurotrauma 28, 2049-2059, 2011

Research Interests: 

In the first study of its kind, Natasha Leporé, PhD, and colleagues have pinpointed structural anomalies in the developing brain that may increase the risk of cognitive disabilities, such as frontal executive dysfunction (FED) and attention deficit hyperactivity disorder (ADHD), in premature newborns. This study will be published by the Public Library of Science in PLOS ONE.

In the News – Press Releases

Researchers at Children’s Hospital Los Angeles Discover a Potential Structural Basis for ADHD in Brain of Preterm Newborns

Natasha Leporé, PhD, and colleagues have pinpointed structural anomalies in the developing brain that may increase the risk of cognitive disabilities, such as frontal executive dysfunction (FED) and attention deficit hyperactivity disorder (ADHD), in premature newborns. The study was published in the journal PLOS ONE. Read more.

ResearCHLA Blog:

A Potential Pathway to Abnormal Brain Development? Neuro-circuitry Altered in Preemies

4650 Sunset Blvd.
Los Angeles, CA 90027