Dr. Geffner is Ron Burkle Chair in the Center for Endocrinology, Diabetes & Metabolism at Children's Hospital Los Angeles, and Professor of Pediatrics at the Keck School of Medicine of the University of Southern California.
He graduated from the Albert Einstein College of Medicine (1975); did his residency at the LAC-USC Medical Center (1975-1979); and completed his fellowship in Pediatric Endocrinology at UCLA (1979-1982). He remained at UCLA through December 31, 2001, rising up the academic ladder to the rank of Professor in 1996. He has been at CHLA since 2002.
His longstanding basic science research interest is in the general area of hormone resistance while, on the clinical side, he is involved in studies of new formulations, delivery systems, and indications for growth-promoting therapies.
Dr. Geffner is principal investigator at CHLA of the NIH-sponsored TODAY2 trial which is studying the long-term outcomes of youth with type 2 diabetes and national endocrinology consultant to the NIH-sponsored PHACS study of adolescents with HIV infection and uninfected children exposed to anti-retroviral therapy in utero, as well as for its mitochondrial sub-study. Dr. Geffner has had a career-long interest in medical and patient education.
He has served a three-year term as an elected member of the Board of Directors of the Pediatric Endocrine Society (PES) and was the President of PES (2014-2015). He completed a six-year term on the American Board of Pediatrics Sub-Board on Pediatric Endocrinology, including the last two years as its chair. He also serves as Medical Advisor on childhood panhypopituitarism for the MAGIC Foundation and the Pituitary Network Association, and is a member of the Scientific Advisory Board of CARES Foundation.
Dr. Geffner is the author of more than 135 peer-reviewed research articles, pediatric endocrinology editor for UpToDate, associate editor of the journal, Pediatric Endocrinology Reviews, and co-editor of the recently published textbook: Pediatric Practice: Endocrinology (McGraw-Hill) (now in its second edition).
Disorders of growth and puberty, and adrenal hyperplasia
Queens College of the City University of New York
Medical School: Albert Einstein College of Medicine
Los Angeles County-University of Southern California Medical Center; Pediatrics
Los Angeles County-University of Southern California Medical Center; Chief Resident Pediatrics
University of California Los Angeles; Pediatric Endocrinology
Pediatrics (American Board of Pediatrics); Pediatric Endocrinology (American Board of Pediatrics)
Pediatric Endocrine Society; Society for Pediatric Research; American Pediatric Society; The Endocrine Society; American Diabetes Association; Los Angeles Pediatric Society
University of Hawaii John A. Burns School of Medicine Department of Cell and Molecular Biology Biomedical Sciences Symposium. Robert E. Wong Endowed Lecturer (2012); and recipient of CARES Foundation Pioneer Award (2013); Thomas Moshang Lecturer, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine (2016); University of Cincinnati/ Cincinnati Children's Hospital Medical Center Medical Student Summer Research Program/Fall Poster Session Keynote Speaker (2017)ss
Garcia-Filion P, Almarzouki H, Fink C, GEFFNER M, Nelson MD, Borcherrt M. Brain malformations do not predict hypopituitarism in young children with optic nerve hypoplasia. Horm Res Paediatr 2017 (in press).
Gravholt CH, Andersen NH, Conway GS, Dekkers OM, GEFFNER ME, Klein KO, Lin AE, Mauras N, Quigley CA, Rubin K, Sandberg DE, Sas TCJ, Silberbach M, Söderström-Anttila V, Stochholm K, van Alfen-van derVelden JA, Woelfle J, Backeljauw PF, on behalf of the International Turner Syndrome Consensus Group. Clinical practice guidelines for the care of girls and women with Turner Syndrome. Eur J Endocrinol 2017 (in press).
Jao J, Kacanek D, Williams PL, GEFFNER ME, Livingston EG, Sperling RS, Patel P, Bardeguez SD, Burchett SK, Chakhtoura N, Scott GB, Van Dyke RB, Abrams EJ for the Pediatric HIV/AIDS Cohort Study (PHACS) and the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1025 Protocol. Birth weight and preterm delivery outcomes of perinatally vs. non-perinatally HIV-infected pregnant women in the U.S.: Results from the PHACS SMARTT study and IMPAACT P1025 protocol. Clin Infect Dis 2017 (in press).
Jacobson DL, Stephensen CB, Miller TL, Patel K, Chen JS, Van Dyke RB, Mirza A, Schuster GU, Hazra R, Ellis A, Brummel SS, GEFFNER ME, Silio M, Spector SA, DiMeglio LA, for the Pediatric HIV/AIDS Cohort Study. Associations of low vitamin D and elevated parathyroid hormone concentrations with bone mineral density in perinatally HIV-infected children. JAIDS, 2017 (in press).
Bellavia A, Williams, P, DiMeglio LA, Hazra R, Abzug MJ, Patel K, Jacobson DL, Van Dyke RB, GEFFNER ME. Delay in sexual maturation in perinatally HIV-infected youth is mediated by poor growth. AIDS 2017;31:1333-1341.
Ferris J, GEFFNER ME. Are aromatase inhibitors in boys with predicted short stature and/or rapidly advancing bone age effective and safe? J Pediatr Endocrinol Metab 2017;30:311-317.
Takemoto JK, Miller TL, Wang J, Jacobson DL, Geffner ME, Van Dyke RB, Gerchenson M. Insulin resistance in HIV-infected youth is associated with decreased mitochondrial respiration. AIDS 2017;31:15-23.
Kim MS,Goodarzian F, Keenan MF, GEFFNER ME, Koppin CM, De Filippo RE, Kokorowski PJ. Testicular adrenal rest tumors in boys and young adults with congenital adrenal hyperplasia. J Urol 2017;197(3 Pt 2):931-936.
Olney RC, Salehi P, Prickett TC, Lima JJ, Espiner EA, Sikes KM, GEFFNER ME. Dynamic Response of c-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short stature. Clin Endocrinol (Oxf) 2016;85:561-568.
Jacobson DL, Patel K, Williams PL, Van Dyke RB, GEFFNER ME, Siberry GK, DiMeglio LA, Crain MJ, Mirza A, Chen JS, McFarland E, Kacanek D, Silio M, Rich K, Borkowsky W, Miller TL for the Pediatric HIV/AIDS Cohort Study. Growth at age two in HIV-exposed uninfected children in the US exposed to antiretrovirals. Pediatr Inf Dis J 2017;36:189-197.
Salehi P, Hsu I, Azen CG, Mittelman SD, GEFFNER ME, Jeandron D. Effects of exenatide on obesity and appetite in overweight adolescents and young adults with Prader-Willi syndrome. Pediatr Obesity 2016;Apr 13.
Kim MS, Dao-Tran A, Davidowitz E, Tseng T, Gilsanz V, Ryabets-Lienhard A, Nguyen E, GEFFNER ME. Carotid intima-media thickness is associated with increased androgens in adolescents and young adults with classical congenital adrenal hyperplasia. Horm Res Paediatr 2016;85:242-249.
Stewart C, Garcia-Filion P, Fink C, Ryabets-Lienhard A, GEFFNER ME, Borchert M. Efficacy of growth hormone replacement on anthropometric outcomes, obesity, and lipids in children with optic nerve hypoplasia and growth hormone deficiency. Int J Pediatric Endocrinol 2016;2016:5.
Walders-Abramson N, Anderson B, Larkin ME, Chang N, Venditti E, Bzdick S, Tryggestad JB, Tan K, GEFFNER ME, Hirst K. Benefits and barriers to participating in longitudinal research of youth-onset type 2 diabetes: results from the TODAY retention survey. Clin Trials 2016;13:240-243.
Kelsey MM, GEFFNER ME, Guandalini C, Pyle L, Tamborlane WV, Zeitler PS, White NH, for the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study Group. Presentation and effectiveness of early treatment of type 2 diabetes in youth: Lessons from the TODAY study. Pediatr Diabetes 2016;17:212-221.
Jao K, Kirmse B, Yu C, Qiu Y, Powis K, Nshom E, Epie F, Muffih Tih P, Sperling RS, Abrams EJ, GEFFNER ME, LeRoith D, Kurland IJ. Lower pre-prandial insulin and altered fuel utilization in HIV/antiretroviral-exposed infants in Cameroon. J Clin Endocrinol Metab 2015;100:3260-3269.
Kim MS, Ryabets-Lienhard A, Dao-Tran A, Mittelman SD, Gilsanz V, Schrager SM, GEFFNER ME. Increased abdominal adiposity in adolescents and young adults with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab 2015;100:E1153-1159.
Dörr HG, Boguszewski M, Dahlgren J, Dunger D, GEFFNER ME, Hokken-Koelega A, Lindberg A, Polak M, Rooman R, on behalf of KIGS International Board. Short children with CHARGE syndrome - Do they benefit from growth hormone therapy? Horm Res Paediatr 2015;84:49-53.
Counts DR, Silverman LA, Rajicic N, GEFFNER ME, Newfield RS, Thornton PS, Carakushansky M, Escobar O, Rapaport R, Levitsky L, Rotenstein D, Hey-Hadavi J, Wajnrajch MP; ISS Study Group. A 4-year, open-label, multicenter, randomized trial of Genotropin® growth hormone in patients with idiopathic short stature: analysis of 4-year data comparing efficacy, efficiency, and safety between an individualized, target-driven regimen and standard dosing. Horm Res Paediatr 2015; 2015;84:79-87.
Huang KE, Mittelman SD, Coates TD, GEFFNER, ME. A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing. J Pediatr Hematol Oncol 2015;37:54-59.
The research of Mitchell Geffner, MD, is clinical/translational in nature and focuses on metabolic abnormalities associated with overweight and excess body fat. Key areas of study include simple obesity and type 2 diabetes, HIV infection, adrenal hyperplasia and diminished pituitary function in the setting of underdeveloped optic nerves. Research studies involve improving understanding of the basis by which these disorders lead to abnormal metabolism as well as to unfavorable long-term cardiovascular health. Finally, improved prevention strategies and treatment approaches are also being investigated.
Visit the Geffner Laboratory.