Dr Goran’s research has focused on the causes and consequences of childhood obesity for 30 years. His work is focused on understanding the metabolic factors linking obesity to increased disease risk during growth and development and using this information as a basis for developing new clinical, behavioral and community approaches for prevention, treatment and risk reduction. He is also especially interested in ethnic disparities in obesity and obesity related diseases including type 2 diabetes and fatty liver disease, with a special interest on the effects of dietary sugar on obesity and metabolic diseases among Hispanic populations. His work also covers maternal-infant nutrition and identifying modifiable factors that can be targeted for interrupting the developmental programming of obesity, including bioactive elements of breastmilk and infant microbiome development. His research has been continuously funded by NIH and other Foundations for the past 25 years during which he has raised almost $50m in funding to support this work.
Dr. Goran has published over 350 professional peer-reviewed articles and reviews. He is the Editor of the “Childhood Obesity: Causes, Consequences and Intervention Approaches” published in 2017, co-editor of “Dietary Sugars and Health” published in late 2014, and currently serves as Editor-in-Chief for Pediatric Obesity. He has been the recipient of a number of scientific awards for his research and teaching, including: The Nutrition Society Medal for Research (1996), The Lilly Award for Scientific Achievement from The Obesity Society (2006), The Bar-Or Award for Excellence in Pediatric Obesity Research, from The Obesity Society (2009), the TOPS award for contributions to obesity research from The Obesity Society (2014), and the Rank Prize Lecture in Nutrition (2018).
University of Manchester (UK)
The Nutrition Society Medal for Research (1996)
The Lilly Award for Scientific Achievement from The Obesity Society (2006)
The Bar-Or Award for Excellence in Pediatric Obesity Research, from The Obesity Society (2009)
The TOPS award for contributions to obesity research from The Obesity Society (2014)
The Rank Prize Lecture in Nutrition (2018).
Goran & Allayee (Multi-PI) 04/01/2016 – 03/31/2020
Nutrigenetic Intervention to Reduce Liver Fat in Hispanics
The goals of this project are to carry out a nutrigenetic clinical trial and determine whether dietary sugar reduction will reduce liver fat content in Hispanic pediatric patients with non-alcoholic fatty liver disease (NAFLD) as a function of genotype.
The Gerber Foundation
Goran (PI) 04/18/2016 – 04/17/2019
Mother's Milk: Determining the Impact of Human Milk Oligosaccharides
We hypothesize that we will be able to identify specific HMOs in breast milk that contribute to rapid infant growth and/or elevated fat accumulation by 24 months of age, and that this will be explained by the effect of these HMOs on specific alterations in the developing infant gut microbiota. In addition, we hypothesize that we will be able to identify specific HMOs that are different in mothers who were overweight/obese versus normal weight before pregnancy, and contribute to altered obesity development in the infant.
Goran (PI) 09/17/2016 – 06/30/2021
Home intervention for reducing sugary drinks & obesity in Hispanic women-infants
The goal of this project is to reduce SSB/juice consumption in low-income, Hispanic post-partum mothers and infants, a segment of the population at high risk for obesity.
Goran (PI) 04/07/2017 – 01/31/2021
Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and Obesity
In this proposal, we will investigate the opposing effects of dietary sugars and HMOs on obesity and cognitive outcomes, focusing on their impact on the developing gut microbiome. This study will move the field forward by identifying how early-life dietary exposures (focusing on dietary sugars, breastfeeding and HMOs) affect gut microbiome development, and how this affects development of obesity, cognition and appetite regulation.
De la Haye & Salvy (Multi-PI) 09/01/2017 – 05/31/2022
Obesity Prevention Infants through Maternal and Social Interaction
This study capitalizes on the strengths and interests of established Home Visitation Programs, which serve at-risk, low-income, diverse mothers and their infants, to test a weekly, in-home evidence-based childhood obesity prevention model delivered in the first 2 years of children’s life. This project represents a unique opportunity to test an innovative model of primary childhood obesity prevention that targets important maternal and social network mechanisms.
Berger PK, Fields DA, Demerath EW, Fujiwara H & Goran MI High-fructose corn syrup-sweetened beverage increases breast milk fructose levels in lactating women: a randomized crossover trial Nutrients May 24; 10(6), 2018 https://www.ncbi.nlm.nih.gov/pubmed/29795005
Noble EE, Hsu TM, Jones RB, Fodor AA, Goran MI & Kanoski SW. Early life sugar consumption affects the microbiome in rodents independent of obesity J Nutrition 147 (1): 20-28, 2017 http://jn.nutrition.org/content/early/2016/11/30/jn.116.238816.abstract
Walker RW & Goran MI Laboratory Determined Sugar Content and Composition of Commercial Infant Formulas, Baby Foods and Common Grocery Items Nutrients 7 (7); 5850-5867, 2015 http://www.ncbi.nlm.nih.gov/pubmed/26193309
Alderete TL, Autran C, Brekke BE, Knight R, Bode L, Goran MI & Fields DA Associations between human milk oligosaccharides and infant body composition in the first six months of life Am J Clin Nutr 102: 1381-1388, 2015 http://www.ncbi.nlm.nih.gov/pubmed/26511224
obesity, nutrition, fatty liver disease, microbiome, maternal-infant nutrition