Investigator, Gastroenterology, Hepatology and Nutrition
Associate Professor of Pediatrics, Keck School of Medicine of USC
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Al Alam, D., Sala, F.G., Baptista, S., Galzote, R., Danopoulos, S., Tiozzo, C., Gage, P., Grikscheit, T., Warburton, D., Frey, M.R., and Bellusci, S. 2012. FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 369:340-8.

Bernard, J.K., McCann, S., Bhardwaj, V., and Frey, M.R. 2012. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. JBC. 287:39850-8.

Yamaoka, T., Frey, M.R., Dise, R.S. and Polk, D.B. 2011. Specific epidermal growth factor receptor autophosphorylation sites promote chemotaxis of colon epithelial cells. Am J Physiol Gastro Liver Physiol. 301(2):G368-76. PMC3154598.

Hilliard V.C., Frey M.R., Dempsey P.J., Peek R.M. Jr and Polk DB. 2011. TNF-alpha converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastro Liver Physiol. 90(10):1415-24. PMC2947587.

Hobbs, S.S., Goettel, J.A., Liang, D., Yan, F., Edelblum, K.L., Frey, M.R., Mullane, M.T. and Polk, D.B. 2011. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastro Liver Physiol. 301(2):G220-9. PMC3154604.

Frey. M.R., Carraro, G, Batra, R.K., Polk, D.B. and Warburton, D. 2011. Sprouty keeps bowel kinases regular in colon cancer while miR-21 targets Sprouty. Cancer Biol Ther. 11:112-114.

Frey, M.R., Hilliard, V.C., Mullane, M.T. and Polk, D.B. 2010. ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. Lab. Invest. 90(10): 1415-24. PMC2947587.

Rosen, M.J., Frey, M.R., Washington, M.K., Chaturvedi, R., Kuhnhein, L.A., Matta, P., Revetta, F.L., Wilson, K.T. and Polk, D.B. 2010. STAT6 Activation in Ulcerative Colitis: A New Target for prevention of lL-13-lnduced Colon Epithelial Cell Dysfunction. Inflammatory Bowel Diseases. 17(11):2224-34. PMC3120916.

Research Interests: 

Mark Frey, PhD, studies the molecular mechanisms that drive intestinal repair after injury or inflammation. His research program in the Saban Research Institute at Children's Hospital Los Angeles is focused on the involvement of ErbB receptor tyrosine kinases and their cognate ligands in the intestinal response to injury, intestinal inflammation and colitis-associated carcinogenesis.

Visit the Frey Laboratory.

Current Funding

NIH R01DK095004: Regulation of Colon Epithelial Cell Survival by NRG4-ErbB4 Signaling.

This project is designed to test the hypothesis that down-regulation of NRG4 worsens colitis, and thus exogenous NRG4 treatment may improve colitis by activating anti-apoptotic signaling in colon epithelial cells.

American Cancer Society Research Scholar Grant: The role of ErbB4 in colon cancer.

This project is designed to test the hypothesis that misregulated ErbB4 expression promotes human colorectal cancer cell survival and metastasis.

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