Research Webinar Series: Single-vesicle analysis of extracellular vesicles in the aqueous humor of retinoblastoma eyes: moving towards an integrated liquid biopsy
Webinar (Please email tecpad@chla.usc.edu if you wish to register)
Presented by
Liya Xu, PhD
Assistant Professor of Research Ophthalmology of USC Roski Eye Institute/CHLA Vision Center
Talk Summary
Retinoblastoma (Rb) is a type of cancer that develops in the eyes of young children and robs their sight, and in upwards of 50% of cases, their eye(s). Extracellular vesicles (EVs) are plasma membrane-enclosed vesicles that act primarily in cell-to-cell communication by delivering a cargo of functional molecules to recipient cells. Our current research aims to investigate the EVs in the AH on single-vesicle level to identify the molecular and functional diversity of distinct EV subpopulations in Rb and define the correlations with clinical presentations and disease.
About the Speaker
Dr. Xu’s research concentrates on integrating patient, model system, and high-content single-particle data to translate clinically observed correlations into a mechanistic understanding of the physical and biological underpinning of the dynamics of ocular cancers, specifically retinoblastoma. Two complementary research projects address the laboratory’s aims of 1) developing the clinical utility of aqueous humor (AH) as a liquid biopsy platform for ocular cancer management, and 2) characterizing the tumor circulome of aqueous humor from RB eyes with multi-omics approaches.
Additional Information
Brought to you by TSRI Office of Training, Education, Career Planning & Development (TECPAD)
Registration is required, email tecpad@chla.usc.edu to receive link.