Translational Research - Fetal and Neonatal Institute

Translational Research

The primary goal of translational research is to convert basic research knowledge into practical applications to enhance health and well-being by integrating organ system-specific areas of cardiovascular and respiratory clinical care and translational developmental research into a cohesive system. The program is built on two components:

  1. Studies into responses of the developmentally regulated organ system to pathological conditions and the treatment modalities.

State-of-the art methods of translational clinical research are used, including but not restricted to functional echocardiography, ultrasonography, near infrared spectroscopy, magnetic resonance imaging (MRI), amplitude-integrated electroencephalogram (EEG) and pulmonary function tests (PFT). This program is built on strong collaborations among several departments and divisions, including the Departments of Radiology, Anesthesiology/Critical Care and the Heart Institute. In doing so, this helps ensure translation of findings of developmental molecular, cellular and whole-animal physiology to the patient’s bedside, as well as a better understanding of applied treatment modalities.

  1. Evidence-gathering to determine that the characterization of pathological conditions is relevant to health and that the treatments we employ are associated with improved outcomes in the developing human.

This evolving component will enable us to verify whether documented pathophysiological findings are useful in predicting outcomes and that our applied treatment modalities are successful both in the short- and the long run.