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An investigation of the utility of non-invasive transcranial Doppler (TCD) ultrasound in the prediction of moyamoya disease in persons with Down syndrome with the goal of identifying cerebrovascular disease before it causes a stroke.

The first Phase IIb clinical trial in Down syndrome regression disorder (DSRD). An open-label, randomized study comparing the safety and efficacy of lorazepam, intravenous immunoglobulin (IVIg) and the Janus Kinase inhibitor (JAK inhibitor), tofacitinib.

To find out the effects of ApoE4 on the Preterm Brain.

It is common for individuals to develop headaches after a lumbar puncture (LP) procedure. While LPs are frequently performed, little is known about the risk factors for headaches in pediatric populations. This study aims to address this gap in knowledge by evaluating the risks factors on headache incidence, duration, onset, psychological state, and impact on quality of life. This study also aims to examine health inequities.