Headshot of a smiling man with medium skin tone and short dark hair wearing glasses, a blue dress shirt and striped tie under a dark suit jacket against a blurred outdoor background

Yi Xiao, PhD, DABCC, CLS

Assistant Director, Core Laboratory, Children’s Hospital Los Angeles
Assistant Professor of Pathology and Laboratory Medicine, Keck School of Medicine of USC

Dr. Yi Xiao is an Assistant Director of the Core Laboratory in the Department of Pathology and Laboratory Medicine at Children's Hospital Los Angeles. He is an Assistant Professor of Clinical Pathology at the Keck School of Medicine of USC. His major areas of research are clinical pathology diagnostic test development, clinical mass spectrometry and biochemical genetics.


Graduate School

Vanderbilt University, Doctor of Philosophy, Biochemistry


Children's Hospital Los Angeles, Clinical Chemistry Fellowship



Diplomate of the American Board of Clinical Chemistry (Clinical Chemistry); MLS(ASCP) Certification (Generalist)


American Association of Clinical Chemistry (AACC)
Academy of Clinical Laboratory Physicians and Scientists (ACLPS)

Medical Awards

Paul E. Strandjord Young Investigator Award (ACLPS 2021)
Young Investigator Award (MSACL 2016-2018)



Xiao Y, Leung EKY. Development and Validation of a Liquid Chromatography Mass Spectrometry Method for Simultaneous Measurement of 25(OH)D3, epi-25(OH)D3, 25(OH)D2, Vitamin A, α-Tocopherol, and γ-Tocopherol. Am J Clin Pathol. 2022 Jan 6;157(1):15-22. doi: 10.1093/ajcp/aqab088. PMID: 34463312.

Hu Y, Xiao Y, Rao Z, Kumar V, Liu H, Lu C. Carbon-carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine. Drug Metab Lett. 2021;14(1):41-53. doi: 10.2174/1872312813666191125095818. PMID: 31763971.

Xiao Y, Li X, Fu X. A rapid and simple LC-MS/MS method for personalized busulfan dosing in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Clin Chim Acta. 2018 Apr;479:190-195. doi: 10.1016/j.cca.2018.01.020. Epub 2018 Jan 16. PMID: 29341904.

Xiao Y, Guengerich FP. Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. J Lipid Res. 2012 Aug;53(8):1610-7. doi: 10.1194/jlr.M027185. Epub 2012 May 16. Erratum in: J Lipid Res. 2013 May;54(5):1521. PMID: 22591743; PMCID: PMC3540858.


Research Summary

Research Interests
Clinical Pathology Diagnostic Test Development, Clinical Mass Spectrometry and Biochemical Genetics