Ryan Schmidt, MD, PhD
Dr. Ryan Schmidt is an Assistant Professor of Clinical Pathology, Keck School of Medicine of the University of Southern California, and Assistant Director of the Clinical Genomics Laboratory in the Center for Personalized Medicine in the Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles. Dr. Schmidt received his PhD in Neuroscience from the University of California, Los Angeles, and his MD from UCLA David Geffen School of Medicine. Dr. Schmidt completed a Molecular Genetic Pathology fellowship at Harvard Medical School and a Clinical Pathology residency at Brigham and Women’s Hospital. He is focused on advancing patient care through the development, implementation, and interpretation of molecular diagnostic tests.
Clinical Bioinformatics
Constitutional Genetics
Molecular Oncology
Education
UCLA David Geffen School of Medicine
Brigham and Women’s Hospital (Clinical Pathology)
Harvard Medical School (Molecular Genetic Pathology)
Accomplishments
Clinical Pathology
American College of Medical Genetics and Genomics (ACMG)
Association of Molecular Pathology (AMP)
College of American Pathologists (CAP)
Paul E. Strandjord Young Investigator Award with Distinction (2016)
Academy of Clinical Laboratory Physicians and Scientists (ACLPS)
Publications
Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, and Plath K. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell 159(7):1681-97, 2014. PMID: 25525883
Mandelker D**, Schmidt RJ**, Ankala A, McDonald Gibson K, Bowser M, Sharma H, Duffy Hynes E,Hegde M, Santani A, Lebo M, Funke B. Navigating highly homologous genes in a molecular diagnostic setting – a resource for clinical next generation sequencing. Genet Med 18(12):1282-89, 2016. PMID:27228465
Lewandrowski K, Keegan A, Makarenko V, Maryamchak E, Mata DA, Palte MJ, Rudolf JW, Safdar N, Schmidt RJ, Stuart L, Xiong Y, Rao L, Melanson SEF, Michael Snyder L. Development of a Commercial Reference Laboratory Elective Rotation for Residents in Clinical Pathology. Am J Clin Pathol 150(6):485-90, 2018. PMID: 30053105
Schmidt RJ, Macleay A, Le LP. VarGrouper – a bioinformatic tool for local haplotyping of deletioninsertion variants from next-generation sequencing data post variant calling. Journal of Molecular Diagnostics 21(3):384-389, 2019. PMID: 30794986
Seifert BA, McGlaughon JL, Jackson SA, Ritter DI, Roberts ME, Schmidt RJ, Thompson BA, Jimenez S, Trapp M, Lee K, Plon SE, Offit K, Stadler ZK, Zhang L, Greenblatt MS, and Ferber MJ. Determining the clinical validity of hereditary colorectal cancer and polyposis susceptibility genes using the Clinical Genome Resource Clinical Validity Framework. Genetics in Medicine 21(7):1507-1516, 2019. PMID:30523343
Research
Molecular Pathology Clinical Innovation Through Novel Assay and Software Development
Identification of Genetic Variants Causing Ocular Disease Though Advanced Molecular Diagnostic Approaches
Identification of Genetic Variant Causing Cleft Lip and/or Cleft Palate Though Advanced Molecular Diagnostic Approaches