Director, Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute
Acting Chief, Division of Infectious Diseases
Investigator, Infectious Diseases
Attending Physician
Associate Professor of Pediatrics (Clinical Scholar), Keck School of Medicine of USC
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Education

Medical School: 

University of California, Davis

Internship: 

Rainbow Babies and Childrens Hospital: Pediatrics

Residency: 

Rainbow Babies and Childrens Hospital: Pediatrics

Fellowship: 

Rainbow Babies and Childrens Hospital: Pediatric Infectious Disease; Childrens Hospital & Rainbow Babies: Clinical Pharmacology

Accomplishments

Certification: 

Pediatrics: American Board of Pediatrics; Pediatric Infectious Diseases: American Board of Pediatrics

Publications: 

Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL; on behalf of The International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases. Individualized antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis. 2014 Jun;14(6):498-509. doi: 10.1016/S1473-3099(14)70036-2. Epub 2014 Apr 24. Review.

Felton TW, Roberts JA, Lodise TP, Van Guilder M, Boselli E, Neely MN, Hope WW. Individualization of Dosing of Piperacillin for Critically Ill Patients: Dosing Software to Optimize Antimicrobial Therapy. Antimicrob Agents Chemother. 2014 May 5. [Epub ahead of print]

Wang NY, Patras KA, Seo HS, Cavaco CK, Rösler B, Neely MN, Sullam PM, Doran KS. Group B Streptococcal Serine-Rich Repeat Proteins Promote Interaction with Fibrinogen and Vaginal Colonization. J Infect Dis. 2014 Apr 15. [Epub ahead of print]

Kortum AN, Rodriguez-Nunez I, Yang J, Shim J, Runft D, O'Driscoll ML, Haire RN, Cannon JP, Turner PM, Litman RT, Kim CH, Neely MN, Litman GW, Yoder JA. Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins. Immunogenetics. 2014 Apr;66(4):267-79. doi: 10.1007/s00251-014-0759-4. Epub 2014 Jan 28.

Rowe HM, Withey JH, Neely MN. Zebrafish as a model for zoonotic aquatic pathogens. Dev Comp Immunol. 2014 Sep;46(1):96-107. doi: 10.1016/j.dci.2014.02.014. Epub 2014 Mar 6. Review.

Research Interests: 

When it comes to choosing a dose for a medication, such as an antibiotic or a cancer drug, we can do far better than the current practice of giving the same dose to everyone. We know that each patients has a unique profile of drug concentrations in the blood, and that if we can shape that profile, we can often improve both the effectiveness and safety of the drug. This is one aspect of the rapidly growing field of personalized medicine, which recognizes that one size definitely does not fit all.  Under the direction of Michael Neely, MD, the Laboratory of Applied Pharmacokinetics and Bioinformatics is one of the world leaders in creating models of drug behavior in populations of patients to find the best dose for an individual patient, a dose that is most likely to achieve the desired concentration profile in blood or tissue.

Visit the Laboratory of Applied Pharmacokinetics and Bioinformatics.  

Funding

  • NIGMS R01 GM068968: Population Pharmacokinetic Modeling and Dual Optimal Control
  • NICHD R01 HD070886: Ontogeny of Voriconazole Pharmacokinetics and Metabolism

Children's Hospital Los Angeles

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MS #51
Los Angeles, CA 90027
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