Laura Perin, MD, is an assistant professor at Keck School of Medicine, University of Southern California. Before joining the faculty at USC she was a research fellow at Harvard School of Medicine, where she obtained her PhD, and a postdoctoral fellow at Children Hospital of Los Angeles. She is a recipient of many intramural and extramural awards including CIRM, American Urology Foundation, Alport Foundation, etc. Her research focuses on the application of human and mouse amniotic fluid stem cells (AFSC) in animal models of acute and chronic kidney, pancreas and lung. In addition, Dr. Perin is investigating the mechanism of action of stem cells and how AFSC provide organ protection thorough their modulatory effects.
Perin L, Da Sacco S, De Filippo RE. Regenerative medicine of the kidney. Advanced Drug Delivery Reviews. 2011 Apr 30;63(4-5):379-87. doi: 10.1016/j.addr.2010.12.001. Epub 2010 Dec 9. Review.
Perin L, Giuliani S, Sedrakyan S, DA Sacco S, De Filippo RE. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatric Research. 2008 May;63(5):467-71. doi: 10.1203/PDR.0b013e3181660653. Review.
Sedrakyan S, Angelow S, De Filippo RE, Perin L. Stem cells as a therapeutic approach to chronic kidney diseases. Current Urology Reports. 2012 Feb;13(1):47-54. doi: 10.1007/s11934-011-0230-0. Review.
Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. Journal of Urology. 2010 Mar;183(3):1193-200. doi: 10.1016/j.juro.2009.11.006. Epub 2010 Jan 22.
Da Sacco S, De Filippo RE, Perin L. Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration. Curr Opin Organ Transplant. 2011 Feb;16(1):101-5. doi: 10.1097/MOT.0b013e3283424f6e. Review.
Laura Perin, PhD, and Roger De Filippo, MD, are principal investigators and co-directors of the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, focus on the development of new stem cell therapeutics and other techniques for organ regeneration.
Using a model for Alport’s Syndrome, a kidney disease characterized by progressive renal fibrosis, the research team injected Amniotic Fluid Stem Cells (AFSC) early in the course of the disease and found that the treatment increased survival time and ameliorated the decline in kidney function.