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Laura Perin, PhD

Vice Chair of Research, Department of Surgery
Associate Professor of Research Urology, Keck School of Medicine of USC

Dr. Laura Perin is an Associate Professor at CHLA, Keck School of Medicine, University of Southern California. Dr Perin is also the Vice Chair of Research in the Department of Surgery at CHLA. Dr Perin obtained a master’s degree in Biological Sciences at the University of Padova, and a Ph.D. in Stem cells and Tissue Engineering at the Harvard School of Medicine. Dr. Perin’s research is focused on studying the mechanisms that regulate kidney damage, with specific attention to glomerular injuries. Dr Perin uses different regenerative approaches including extracellular vesicles, stem cells, organ a chip technology, and development biology to understand the molecular mechanisms that modulate renal regeneration. Dr. Perin has established has received many intramural and extramural awards and has published more than 70 articles in the field of renal regeneration.

Publications

Publications

Petrosyan A, Villani V, Aguiari P, Thornton ME, Wang Y, Rajewski A, Zhou S, Cravedi P, Grubbs BH, De Filippo RE, Sedrakyan S, Lemley KV, Csete M, Da Sacco S, Perin L. Identification and Characterization of the Wilms Tumor Cancer Stem Cell. Adv Sci (Weinh). 2023 Jul;10(20):e2206787. doi: 10.1002/advs.202206787. Epub 2023 Apr 28. PubMed PMID: 37114795; PubMed Central PMCID: PMC10369255.
Frank CN, Hou X, Petrosyan A, Villani V, Zhao R, Hansen JR, Clair G, Salem F, De Filippo RE, Cravedi P, Lemley KV, Perin L. Effect of disease progression on the podocyte cell cycle in Alport Syndrome. Kidney Int. 2022 Jan;101(1):106-118. doi: 10.1016/j.kint.2021.08.026. Epub 2021 Sep 23. PubMed PMID: 34562503.

Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Nat Commun. 2019 Aug 13;10(1):3656. doi: 10.1038/s41467-019-11577-z. PubMed PMID: 31409793; PubMed Central PMCID: PMC6692336.
Sedrakyan S, Villani V, Da Sacco S, Tripuraneni N, Porta S, Achena A, Lavarreda-Pearce M, Petrosyan A, Soloyan H, Filippo RE, Bussolati B, Perin L. Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage. Sci Rep. 2017 Dec 4;7(1):16875. doi: 10.1038/s41598-017-17061-2. PubMed PMID: 29203902; PubMed Central PMCID: PMC5715019.