Director, Children's Center for Cancer and Blood Diseases
Director, Pediatric Hematology-Oncology Fellowship Training Program
Attending Physician; Hematology, Oncology and Blood and Marrow Transplantation
Professor of Pediatrics, Keck School of Medicine of USC
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Alan S. Wayne, MD, serves as the Director of the Children's Center for Cancer & Blood Diseases at CHLA, the Head of the Division of Hematology, Oncology and Blood & Marrow Transplantation in the Department of Pediatrics, the Director of the Pediatric Hematology/Oncology Fellowship Training Program, the Associate Director for Pediatric Oncology at the USC Norris Comprehensive Cancer Center and Professor of Pediatrics at the Keck School of Medicine, University of Southern California. He oversees the research, clinical and education programs in pediatric hematology, oncology and hematopoietic stem cell transplantation within these institutions. Prior to joining CHLA/USC in 2013, Dr. Wayne served as clinical director of the Pediatric Oncology Branch of the National Cancer Institute at the National Institutes of Health for 14 years.

Clinical Interests

  • Hematologic malignancies: Hematopoietic stem cell transplantation
  • Bench-to-bedside development of targeted, immune-based and cellular therapies for leukemias and lymphomas, with a primary focus on relapsed/refractory acute lymphoblastic leukemia
  • Biology, prevention and treatment of relapse of hematologic malignancies after allogeneic hematopoietic stem cell transplantation
  • Natural history and treatment of rare lymphomas of childhood


Medical School: 

Honors Program in Medical Education, Northwestern University Medical School


Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School


Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School

Chief Residency, Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School


Pediatric Hematology-Oncology, Boston Children’s Hospital; Dana-Farber Cancer Institute



The American Board of Pediatrics, Sub-board of Pediatric Hematology-Oncology

Medical Memberships: 

American Pediatric Society
The American Society of Hematology
The American Society of Pediatric Hematology/Oncology
Children’s Oncology Group
Pediatric Blood and Marrow Transplant Consortium

Medical Awards: 

The Best Doctors in America, 1995-2015
National Institutes of Health Director’s Award, NIH, 2007
The Sidney Farber Award, 1988

Other Information

Specialty Interest: 

Pediatric hematology-oncology

Research Interests: 

His primary research efforts are directed towards the development of new treatment approaches for leukemias and lymphomas with a focus on relapsed/refractory acute lymphoblastic leukemia. He develops and conducts collaborative laboratory, translational, and clinical investigations, including bench-to-bedside development of targeted, immune-based and cellular therapies, investigator-initiated clinical trials and industry-sponsored studies. He serves as the Medical Director of the Therapeutic Advances in Childhood Leukemia/Lymphoma (TACL) Consortium, which is a multinational clinical trials group that conducts Phase I and II trials. He also plays a leadership role in international efforts in the area of post-transplant relapse of hematologic malignancies, the primary aim of which is to study the biology, prevention and treatment of relapse after hematopoietic stem cell transplant.

4650 Sunset Blvd.
MS #54
Los Angeles, CA 90027
Phone: 323-361-4624Office