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Alan S. Wayne, MD, serves as Director of the Cancer and Blood Disease Institute at CHLA, Head of the Division of Hematology-Oncology in the Department of Pediatrics, Associate Director for Pediatric Oncology at the USC Norris Comprehensive Cancer Center and Professor of Pediatrics and Medicine at the Keck School of Medicine, University of Southern California. In these roles, he oversees all research, treatment, prevention and education programs in pediatric hematology, oncology and hematopoietic stem cell transplantation within these institutions. Prior to joining CHLA/USC in 2013, Dr. Wayne served for 14 years as Clinical Director of the Pediatric Oncology Branch of the National Cancer Institute at the National Institutes of Health.
Clinical Interests
Hematologic malignancies; hematopoietic stem cell transplantation and cellular therapy; cancer immunotherapy
Bench-to-bedside development of targeted, immune-based and cellular therapies for leukemias and lymphomas, with a primary focus on relapsed/refractory acute lymphoblastic leukemia
Biology, prevention and treatment of relapse of hematologic malignancies after allogeneic hematopoietic stem cell transplantation
Education
Honors Program in Medical Education, Northwestern University Medical School
Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School
Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School
Chief Residency, Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School
Pediatric Hematology-Oncology, Boston Children’s Hospital; Dana-Farber Cancer Institute
Accomplishments
American Board of Pediatrics, Sub-board of Pediatric Hematology-Oncology
Society for Pediatric Research
American Pediatric Society
American Society of Hematology
American Society of Pediatric Hematology/Oncology
Children’s Oncology Group
Top Doctors, Los Angeles Business Journal, 2020
Top Doctors, Los Angeles Magazine, 2018-19
Top Doctors, Pasadena Magazine, 2015-19
Medical Advancement Award, T.J. Martell Foundation, 2018
Healing Award, Tower Cancer Research Foundation, 2018
The Best Doctors in America, 1995-2015
National Institutes of Health Director’s Award, National Institutes of Health, 2007
The Sidney Farber Award, 1988
Other Information
Pediatric hematology-oncology
Dr. Wayne’s primary research efforts are directed towards the development of new treatment approaches for leukemias and lymphomas with a focus on relapsed/refractory acute lymphoblastic leukemia. He develops and leads collaborative laboratory, translational and clinical investigations, including bench-to-bedside development of targeted, immune-based and cellular therapies. He serves as the Medical Director of the Therapeutic Advances in Childhood Leukemia/Lymphoma (TACL) Consortium, a multinational clinical trials group that conducts Phase I and II trials. He is also an international leader in the area of post-transplant relapse of hematologic malignancies, with the primary aim to study the biology, prevention and treatment of relapse after hematopoietic stem cell transplant.
Billboard - TJ Martell Foundation Presents CHLA’s Alan Wayne With Spirit of Excellence Award
Clinical trial to test immunotherapy for hard-to-treat leukemia
Science Daily- Unique next generation sequencing-based panel designed for pediatric cancer research
Fierce Biotech- Kite Pharma’s CART drug begins LA hospital trial in children
Newsweek- New Therapy Leads to Lasting Remission in Leukemia Patients
ABC Good Morning America- Shutdown Prompts Fear, Confusion Among Cancer Patients
San Diego Tribune- CAR T cell leukemia therapy tested at Children's Hospital Los Angeles
CBS News- Childhood Cancer Deaths Continue to Decline
KTLA 5- Fighting Pediatric Cancer: The 30th Annual Nautica Malibu Triathlon
ABC 7 Eyewitness News- Elex Michaelson goes live with Dr. Wayne at Nautica Malibu Triathlon
FOX 11 — Courageous Teen Brings Awareness to Childhood Cancer One Lemonade Stand at a Time
Science Daily — Disruptive technology for the treatment of hemophilia
ABC7 - Nautica Malibu Triathlon Raises $1.1 Million for CHLA
CBS News - Young Siblings Diagnosed With Same Brain Cancer Within Weeks of Each Other
Inside Edition – California Siblings With Same Type of Rare Brain Tumor Are Baffling Doctors
ResearCHLA Magazine 2017
Cellular Therapy - Supercharging a patient’s own cells to battle blood diseases
ResearCHLA Blog
Tackling Leukemia with CAR T-Cells
“Patients don’t fail therapy. But sometimes, therapy fails them.”
Clinical Trial Results: Patients with Leukemia Show High Remission Rates after Immunotherapy