Alan S. Wayne, MD

Alan S. Wayne, MD

Pediatrician-in-Chief and Senior Vice President of Academic Affairs
Pasadena Guild Chair
Children’s Hospital Los Angeles
Chair, Department of Pediatrics
Professor of Pediatrics and Medicine
Keck School of Medicine of USC

Alan S. Wayne, MD, leads the implementation of the Department’s strategic and operating plans; recruitment, development and retention of faculty at CHLA; as well as oversees the hospital’s educational and research advancements, including those performed at The Saban Research Institute, CHLA's freestanding research facility dedicated to finding new treatments and cures for the most complex childhood diseases. Dr. Wayne also serves on CHLA’s Board of Directors. Dr. Wayne's prior roles at CHLA have included Chief, Division of Hematology-Oncology and Director, Cancer and Blood Disease Institute. Prior to joining CHLA/USC in 2013, Dr. Wayne served for 14 years as Clinical Director of the Pediatric Oncology Branch of the National Cancer Institute at the National Institutes of Health.

Clinical Interests

Hematologic malignancies; hematopoietic stem cell transplantation and cellular therapy; cancer immunotherapy

Bench-to-bedside development of targeted, immune-based and cellular therapies for leukemias and lymphomas, with a primary focus on relapsed/refractory acute lymphoblastic leukemia

Biology, prevention and treatment of relapse of hematologic malignancies after allogeneic hematopoietic stem cell transplantation


Medical School

Honors Program in Medical Education, Northwestern University Medical School


Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School


Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School

Chief Residency, Pediatrics, Department of Medicine, Boston Children’s Hospital, Harvard Medical School


Pediatric Hematology-Oncology, Boston Children’s Hospital; Dana-Farber Cancer Institute



American Board of Pediatrics, Sub-board of Pediatric Hematology-Oncology

Professional Memberships

Society for Pediatric Research
American Pediatric Society
American Society of Hematology
American Society of Pediatric Hematology/Oncology
Children’s Oncology Group


Top Doctors, Los Angeles Business Journal, 2020
Top Doctors, Los Angeles Magazine, 2018-19
Top Doctors, Pasadena Magazine, 2015-19
Medical Advancement Award, T.J. Martell Foundation, 2018
Healing Award, Tower Cancer Research Foundation, 2018
The Best Doctors in America, 1995-2015
National Institutes of Health Director’s Award, National Institutes of Health, 2007
The Sidney Farber Award, 1988

Areas of Focus

Pediatric hematology-oncology



Dr. Wayne’s primary research efforts are directed towards the development of new treatment approaches for leukemias and lymphomas with a focus on relapsed/refractory acute lymphoblastic leukemia. He develops and leads collaborative laboratory, translational and clinical investigations, including bench-to-bedside development of targeted, immune-based and cellular therapies. He serves as the Medical Director of the Therapeutic Advances in Childhood Leukemia/Lymphoma (TACL) Consortium, a multinational clinical trials group that conducts Phase I and II trials. He is also an international leader in the area of post-transplant relapse of hematologic malignancies, with the primary aim to study the biology, prevention and treatment of relapse after hematopoietic stem cell transplant.

Research Studies

UCART19 is intended to treat CD19-positive B lymphoid malignancies in paediatric and adult populations.

This study aims to evaluate the side effects (good and bad) of giving Vincristine Suflate Liposome Infection (also known as Marqibo®) - a drug approved for leukemia treatment in adults but that is experimental in children - with other standard chemotherapy drugs and to measure how effective the combination is at treating children and young adults with leukemia that has come back after initial treatment.


The Malibu Times - The Malibu Triathlon returns to Malibu Sept. 30 to Oct. 1

Yahoo! Finance - Children’s Hospital Los Angeles Names Alan S. Wayne, MD, as Pediatrician-in-Chief and Senior Vice President of Academic Affairs

KTLA - Malibu Triathlon underway to raise funds for cancer research at Children’s Hospital Los Angeles - Justin Turner Visits Children’s Hospital Los Angeles To Have Adidas Cleats Designed For Childhood Cancer Awareness Month

Billboard - TJ Martell Foundation Presents CHLA’s Alan Wayne With Spirit of Excellence Award

ABC7 - Athletes raise money for childhood cancer research at Children's Hospital Los Angeles in Malibu triathlon 

Hyundai Hope on Wheels – Hyundai Hope on Wheels Presents Children’s Hospital Los Angeles with Hyundai Hope Scholar and Young Investigator Grant Totaling $500,000 to Support Pediatric Cancer Research

Clinical trial to test immunotherapy for hard-to-treat leukemia

Yahoo Finance- Children’s Hospital Los Angeles to initiate Clinical Trial for Kids with Treatment-Resistant Leukemia

Science Daily- Unique next generation sequencing-based panel designed for pediatric cancer research

Fierce Biotech- Kite Pharma’s CART drug begins LA hospital trial in children 

Newsweek- New Therapy Leads to Lasting Remission in Leukemia Patients

ABC Good Morning America- Shutdown Prompts Fear, Confusion Among Cancer Patients

San Diego Tribune- CAR T cell leukemia therapy tested at Children's Hospital Los Angeles

CBS News- Childhood Cancer Deaths Continue to Decline

KTLA 5- Fighting Pediatric Cancer: The 30th Annual Nautica Malibu Triathlon

ABC 7 Eyewitness News- Elex Michaelson goes live with Dr. Wayne at Nautica Malibu Triathlon

FOX 11 — Courageous Teen Brings Awareness to Childhood Cancer One Lemonade Stand at a Time 

L.A. Times - Three-time Nautica Malibu Triathlon Celebrity Division Winner Talks about helping Kids at Children’s Hospital Los Angeles 

Science Daily — Disruptive technology for the treatment of hemophilia

KTLA — Children’s Hospital Los Angeles Preparing for Annual Triathlon in Malibu to Raise Funds for Childhood Cancer

ABC7 - Nautica Malibu Triathlon Raises $1.1 Million for CHLA

CBS News - Young Siblings Diagnosed With Same Brain Cancer Within Weeks of Each Other

Inside Edition – California Siblings With Same Type of Rare Brain Tumor Are Baffling Doctors 

ResearCHLA Blog

Tackling Leukemia with CAR T-Cells

“Patients don’t fail therapy. But sometimes, therapy fails them.”

Clinical Trial Results: Patients with Leukemia Show High Remission Rates after Immunotherapy