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Content related to New Approach to Modeling Ewing Sarcoma Leads to a Novel Discovery

Research and Breakthroughs

Can a Tiny Fish Transform Treatment for Childhood Cancers?

October 13, 2021
A physician-scientist is harnessing the power of zebrafish—and a new, state-of-the-art facility—to develop innovative treatments for solid tumors in children.
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Research and Breakthroughs

Controlling Cell Turnover in the Intestinal Lining

April 8, 2016
Shedding epithelial cells in the intestine. Image courtesy of Mark R. Frey, PhD, The Saban Research Institute, Children’s Hospital Los Angeles. The lining of the intestine is the most rapidly-renewing
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Research and Breakthroughs

Study Leads to Orphan Drug Status for Acute Myeloid Leukemia

January 10, 2023
Research at Children’s Hospital Los Angeles enables a novel compound to achieve a key designation from the Food and Drug Administration.
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Research and Breakthroughs

A Bench-to-Bedside Approach to Wilms Tumor

October 16, 2020
Program combines clinical expertise and basic science to advance care in an understudied cancer.
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Research and Breakthroughs

When Good Immune Cells Turn Bad

October 10, 2017
Investigators at the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles have identified new findings about an immune cell – called a tumor-associated macrophage – that
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Research and Breakthroughs

Oncoproteins Interact to Promote Cancer Cell Growth in Retinoblastoma

October 17, 2016
Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176 cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD. Researchers at The Saban Research Institute of Children’s Hospital Los
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Research and Breakthroughs

Theranostics: Combining Cancer Therapeutics and Diagnostics

October 28, 2015
Researchers at The Saban Research Institute, Cedars-Sinai Medical Center and Caltech have unveiled a novel nanoparticle complex that induces tumor cell death while enhancing contrast in MRI images.
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Research and Breakthroughs

Back to the Basics: Understanding the Genetics of Cancer

February 24, 2016
In 2006, researchers studying obesity stumbled upon a gene called PID1 (Phosphotyrosine Interaction Domain containing 1). They found the gene played a role in insulin resistance in obese patients
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Research and Breakthroughs

CHLA Scientists Develop Breakthrough In Vitro Model

August 13, 2019
Scientists at Children’s Hospital Los Angeles develop first physiologically-accurate in vitro model of the human kidney glomerulus, representing a milestone in the field of kidney disease research
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