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Content related to Children’s Hospital Los Angeles Researcher Awarded $1.5 Million to Study “Gatekeeper Protein” in the Intestines

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Press Release

Mark Frey, PhD, Receives $1.7M Grant to Study How the GI Tract Repairs Itself After Injury

July 22, 2019
Chemotherapy and radiation target cancer cells but these treatments produce unwanted side effects on healthy tissue. The intestines are particularly sensitive to this toxicity. A better understanding
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Research and Breakthroughs

A Clearer Picture of Inflammatory Bowel Disease (IBD): A Foundation for Newer Treatments

March 26, 2021
A new study at Children’s Hospital Los Angeles outlines an important molecular pathway in the intestines that could improve IBD treatments
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Research and Breakthroughs

Could stem cells heal IBD?

September 9, 2016
Inflammatory bowel disease, which includes Crohn’s disease and ulcerative colitis, affects more than 1.4 million Americans and is globally becoming more common. Current medication targets the chronic
Read more
Hand wearing a blue medical glove holds a DNA sample.
Work That Matters

Meet Some of our Research Trainees

August 2, 2021
Astgik Petrosyan, PhD Astgik is a senior postdoctoral researcher working in Laura Perin ’s laboratory. When asked about where her interest in biology comes from, her answer took us back to the
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Research and Breakthroughs

Targeting Macrophages in IBD

January 3, 2017
Inflammatory Bowel Disease (IBD) is a debilitating, incurable condition affecting approximately 1.5 million patients in the USA, with annual health care costs of more than $6 billion. The precise
Read more
Young girl sitting on couch, holding stomach due to stomach pain
Press Release

Treatment for Inflammatory Bowel Disease Doesn’t Always Work; New Study Uncovers Why

October 26, 2020
Investigators at The Saban Research Institute at Children’s Hospital Los Angeles have uncovered a role that TNF and its receptor play in intestinal health that will lead to a better understanding of
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Research and Breakthroughs

Controlling Cell Turnover in the Intestinal Lining

April 8, 2016
Shedding epithelial cells in the intestine. Image courtesy of Mark R. Frey, PhD, The Saban Research Institute, Children’s Hospital Los Angeles. The lining of the intestine is the most rapidly-renewing
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Hand wearing a blue medical glove holds a DNA sample.
Work That Matters

Meet Some of our Research Trainees

August 13, 2021
Michael Schumacher, PhD Mike is a postdoctoral researcher in Dr. Mark Frey’s lab looking for alternate therapeutic targets for children with inflammatory bowel disease. Mike grew up in Ohio, where he
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Advice From Our Experts

What Is Necrotizing Enterocolitis?

March 7, 2022
Early treatment can help overcome this life-threatening condition in premature infants.
Read more

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