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Content related to Targeting Macrophages in IBD

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Research and Breakthroughs

Controlling Cell Turnover in the Intestinal Lining

April 8, 2016
Shedding epithelial cells in the intestine. Image courtesy of Mark R. Frey, PhD, The Saban Research Institute, Children’s Hospital Los Angeles. The lining of the intestine is the most rapidly-renewing
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Research and Breakthroughs

Could stem cells heal IBD?

September 9, 2016
Inflammatory bowel disease, which includes Crohn’s disease and ulcerative colitis, affects more than 1.4 million Americans and is globally becoming more common. Current medication targets the chronic
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Frey Intestine.jpg
Press Release

Mark Frey, PhD, Receives $1.7M Grant to Study How the GI Tract Repairs Itself After Injury

July 22, 2019
Chemotherapy and radiation target cancer cells but these treatments produce unwanted side effects on healthy tissue. The intestines are particularly sensitive to this toxicity. A better understanding
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Research and Breakthroughs

A Clearer Picture of Inflammatory Bowel Disease (IBD): A Foundation for Newer Treatments

March 26, 2021
A new study at Children’s Hospital Los Angeles outlines an important molecular pathway in the intestines that could improve IBD treatments
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Young girl sitting on couch, holding stomach due to stomach pain
Press Release

Treatment for Inflammatory Bowel Disease Doesn’t Always Work; New Study Uncovers Why

October 26, 2020
Investigators at The Saban Research Institute at Children’s Hospital Los Angeles have uncovered a role that TNF and its receptor play in intestinal health that will lead to a better understanding of
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Research and Breakthroughs

Children’s Hospital Los Angeles Researcher Awarded $1.5 Million to Study “Gatekeeper Protein” in the Intestines

August 6, 2020
Mark Frey, PhD, an investigator at The Saban Research Institute of Children’s Hospital Los Angeles, studies how the intestines repair themselves after injury.
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Research and Breakthroughs

Short Bowel Syndrome Results in Changes to Gene Expression

January 30, 2017
Investigators at Children’s Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by
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Research and Breakthroughs

When Good Immune Cells Turn Bad

October 10, 2017
Investigators at the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles have identified new findings about an immune cell – called a tumor-associated macrophage – that
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Research and Breakthroughs

Latino and African-American High School Students Take On Biomedical Research

August 22, 2014
Explaining the role of ErbB4 regulators in inflammatory bowel disease (IBD), Patricia Lozano exudes poise and confidence. In front of fellow interns, she reviews the causes of IBD and discusses how
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