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Content related to A Clearer Picture of Inflammatory Bowel Disease (IBD): A Foundation for Newer Treatments

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Research and Breakthroughs

Controlling Cell Turnover in the Intestinal Lining

April 8, 2016
Shedding epithelial cells in the intestine. Image courtesy of Mark R. Frey, PhD, The Saban Research Institute, Children’s Hospital Los Angeles. The lining of the intestine is the most rapidly-renewing
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Young girl sitting on couch, holding stomach due to stomach pain
Press Release

Treatment for Inflammatory Bowel Disease Doesn’t Always Work; New Study Uncovers Why

October 26, 2020
Investigators at The Saban Research Institute at Children’s Hospital Los Angeles have uncovered a role that TNF and its receptor play in intestinal health that will lead to a better understanding of
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Research and Breakthroughs

Targeting Macrophages in IBD

January 3, 2017
Inflammatory Bowel Disease (IBD) is a debilitating, incurable condition affecting approximately 1.5 million patients in the USA, with annual health care costs of more than $6 billion. The precise
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Research and Breakthroughs

Children’s Hospital Los Angeles Researcher Awarded $1.5 Million to Study “Gatekeeper Protein” in the Intestines

August 6, 2020
Mark Frey, PhD, an investigator at The Saban Research Institute of Children’s Hospital Los Angeles, studies how the intestines repair themselves after injury.
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Research and Breakthroughs

Can Butyrate Help Hispanic Children With Ulcerative Colitis?

October 11, 2022
A clinical trial at Children’s Hospital Los Angeles is the first to study butyrate therapy in Hispanic children with ulcerative colitis.
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Research and Breakthroughs

Could stem cells heal IBD?

September 9, 2016
Inflammatory bowel disease, which includes Crohn’s disease and ulcerative colitis, affects more than 1.4 million Americans and is globally becoming more common. Current medication targets the chronic
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Advice From Our Experts

What Is Necrotizing Enterocolitis?

March 7, 2022
Early treatment can help overcome this life-threatening condition in premature infants.
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Work That Matters

Meet Some of our Research Trainees

August 2, 2021
Astgik Petrosyan, PhD Astgik is a senior postdoctoral researcher working in Laura Perin ’s laboratory. When asked about where her interest in biology comes from, her answer took us back to the
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Press Release

Mark Frey, PhD, Receives $1.7M Grant to Study How the GI Tract Repairs Itself After Injury

July 22, 2019
Chemotherapy and radiation target cancer cells but these treatments produce unwanted side effects on healthy tissue. The intestines are particularly sensitive to this toxicity. A better understanding
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