Chair, Department of Anesthesiology Critical Care Medicine
  • Summary
  • Publications
  • Research
  • Media
  • Locations

Clinical Interests

Randall Wetzel, MBBS, MRCP, LRCS, MSB, FAAP, FCCM, is using information technologies to improve the delivery of critical care medicine to critically ill children and their families.

Education

Medical School: 

St. Bartholomew's Hospital Medical College, London

Graduate School: 

Johns Hopkins University (MSB - Medicine)

Internship: 

St. Bartholomew's Hospital/London, Internal Medicine
St. Bartholomew's Hospital/London, Otolaryngology

Residency: 

Rainbow Babies and Children's Hospital, Pediatric Residency
Johns Hopkins Hospital, Anesthesiology/Critical Care Medicine (Chief Resident)

Fellowship: 

Rainbow Babies and Children's Hospital, Pediatric Cardiology/Critical Care
Guy's Hospital and the Hospital for Sick Children, Pediatric Anesthesiology/Critical Care Medicine
Wilmer Eye Institute/Johns Hopkins Hospital, Pediatric Critical Care

Accomplishments

Certification: 

Pediatrics, American Board of Pediatrics
Pediatric Critical Care Medicine, American Board of Pediatrics
Anesthesiology, American Board of Anesthesiology

Medical Memberships: 

Association of University Anesthesiologists (AUA)
American Physiological Society (APS)
Society of Critical Care Medicine, Fellow (FCCM)
Intensive Care Society of United Kingdom (ICS)
American Society of Anesthesiologists (ASA)
European Academy of Anaesthesiology (EAS)
Society for Pediatric Anesthesia (SPA)
American Academy of Pediatrics, Fellow (FAAP)
American Telemedicine Association (ATA)

Publications: 

Gupta P, Tang X, Gall CM, Lauer C, Rice TB, Wetzel RC. Epidemiology and outcomes of in-hospital cardiac arrest in  critically ill children across hospitals of varied center volume: A multi-center analysis. Resuscitation. 2014 Aug 7. pii: S0300-9572(14)00679-0. doi: 10.1016/j.resuscitation.2014.07.016. [Epub ahead of print]

Gupta P, Tang X, Gossett JM, Gall CM, Lauer C, Rice TB, Carroll CL, Kacmarek RM, Wetzel RC. Association of center volume with outcomes in critically ill children with acute asthma. Ann Allergy Asthma Immunol. 2014 Jul;113(1):42-7. doi: 10.1016/j.anai.2014.04.020. Epub 2014 May 14

Khemani RG, Celikkaya EB, Shelton CR, Kale D, Ross PA, Wetzel RC, Newth CJ. Algorithms to estimate PaCO2 and pH using noninvasive parameters for children with Hypoxemic Respiratory Failure. Respir Care. 2013 Dec 24. [Epub ahead of print]

Gupta P, Green JW, Tang X, Gall CM, Gossett JM, Rice TB, Kacmarek RM, Wetzel RC. Comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. JAMA Pediatr. 2014 Mar 1;168(3):243-9. doi: 10.1001/jamapediatrics.2013.4463

Marcin JP, Wetzel RC. The parsimonious pediatric index of mortality. Pediatr Crit Care Med. 2013 Sep;14(7):718-9. doi: 10.1097/PCC.0b013e3182a1251b

Benjamin M. Marlin, David C. Kale, Robinder G. Khemani, and Randall C. Wetzel. 2012. Unsupervised pattern discovery in electronic health care data using probabilistic clustering models. In Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium(IHI '12). ACM, New York, NY, USA, 389-398. DOI=10.1145/2110363.2110408 http://doi.acm.org/10.1145/2110363.2110408

Kale D, Hart A, Mattmann C, Khemani RG, Ross R, Vee P, Terry J, Wetzel RC, and Crichton D. An Open Source, Grid-based Software Framework for Management and Sharing of Pediatric ICU Data. In proceedings of the 9th International Conference on Complexity in Acute Illness (ICCAI 2010), 2010

Burke RV1, Berg BM, Vee P, Morton I, Nager A, Neches R, Wetzel R, Upperman JS. Using robotic telecommunications to triage pediatric disaster victims. J Pediatr Surg. 2012 Jan;47(1):221-4. doi: 10.1016/j.jpedsurg.2011.10.046

Enriquez R, and Wetzel R. Anesthetic Neurotoxicity in Infants and Children: “Does anesthesia make my child dumb?” California Pediatrician (AAP) Spring 2012

D. J. Crichton, C. A. Mattmann, A. F. Hart, D. Kale, R. G. Khemani, P. Ross, S. Rubin, P. Veeravatanayothin, A. Braverman, C. Goodale, R. C. Wetzel, "An informatics architecture for the Virtual Pediatric Intensive Care Unit," Computer-Based Medical Systems, IEEE Symposium on, pp. 1-6, 2011 24th International Symposium on Computer-Based Medical Systems, 2011. http://www.computer.org/csdl/proceedings/cbms/2011/1189/00/05999031-abs.html

Research Interests: 
  • Machine learning, data mining and artificial intelligence
  • Virtual Pediatric Intensive Care Unit (VPICU)

Machine Learning, Data Mining and Artificial Intelligence

Researchers are using advanced computational techniques and artificial intelligence to detect categories in raw medical data from disparate data sources, allowing the most recent information about large numbers of critically ill children to be data mined. This enables researchers to find similarities between a patient and historical populations with known outcomes to provide decision support for diagnosis, management and therapy, while aiding disease detection, directing patient care, and ensuring quality and safety.

Randall Wetzel, MD, has been awarded a Challenge Grant in Health and Science Research by the National Institutes of Health (NIH) National Library of Medicine to research advanced computational frameworks for decision support in critically ill children. The study aims to provide information for patient management by providing outcomes data on previous patients with similar diagnosis and symptoms.

Virtual PICU

Every day doctors observe the outcomes of the treatment they provide for thousands of patients. These experiences serve as practical therapeutic trials, conducted on a patient-by-patient basis. With the increasing adoption of electronic health care records, hospitals and clinics are collecting data from thousands of these experiments daily. However, much of it remains inaccessible and unsearchable, and providers are unable to learn from this vast accumulated experience. The Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit (VPICU) aims to create a common information space for the international community of caregivers providing critical care for children. The VPICU will build extended databases to allow inter-institutional data sharing to create extended, multi-center knowledge bases. The VPICU will also improve education, quality enhancement and telemedicine in this field.

4650 Sunset Blvd.
Los Angeles, CA 90027
Phone: 323-361-2557Office
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