Jon A. Detterich, MD is an Assistant Professor of Pediatrics at the University of Southern California (USC) in the division of pediatric cardiology at Children’s Hospital Los Angeles with a subspecialty in non-invasive cardiac imaging, including fetal echocardiography. He graduated from the University of California, Irvine (UCI) with a Bachelors of Science in Biological Sciences in 1997, and then attended the Medical College of Wisconsin where he graduated in 2003. He completed his pediatric internship and residency at Children’s Hospital Los Angeles in 2006 and fellowship in pediatric cardiology at Children’s Hospital Los Angeles in 2009. He then completed a fourth year of subspecialty training and research in cardiac MRI and fetal echocardiography at Children’s Hospital Los Angeles while being supported by a scholar grant from the NHLBI. Dr. Detterich is a board certified pediatrician since 2006 with subspecialty board certification in pediatric cardiology since 2010.
Dr. Detterich is involved in the detection and pre-term management of fetuses with congenital heart disease and in the post natal care of these patients in the clinic and further imaging of congenital heart lesions utilizing echocardiography and cardiac MRI. He is a representative of the Heart Institute at CHLA and an active member of The Institute for Fetal Maternal Health (IMFH) at Hollywood Presbyterian Medical Center (HPMC) to care for fetuses diagnosed with major congenital malformations.
1. Pediatric cardiology, 2. Non-invasive imaging: cardiac MRI and fetal echocardiograph, 3. Cardiovascular disease in children and young adults with sickle cell anemia.
Medical College of Wisconsin
Children's Hospital Los Angeles: General Pediatrics
Children's Hospital Los Angeles: General Pediatrics
Children's Hospital Los Angeles: Pediatric Cardiology; Subspecialty Training: Cardiac MRI and Fetal Echocardiography
Pediatrics: American Board of Pediatrics; Pediatric Cardiology, American Board of Pediatrics
American Academy of Pediatrics, American Heart Association, American College of Cardiology, The Society for Cardiac Magnetic Resonance.
Fourth Year Medical Student Teaching Award, Medical College of Wisconsin, 2003; Pediatric Legislative Advocacy Award, Children’s Hospital Los Angeles, 2006; Travel Award, American Society of Hematology, 2007.
Jones, K., Tierney, K., Grubbs, B.H., Pruetz, J.D., Detterich, J. & Chmait, R.H. (2011). Fetoscopic Laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction. Fetal Diagnosis and Therapy, 31(3), 191-195.
Detterich, J., Noetzli, L., Dorey, F., Bar-Cohen, Y., Harmatz, P., Coates, T. & Wood, J. Electrocardiographic consequences of cardiac iron overload in thalassemia major. (2011). American Journal of Hematology, in press. PMCID: PMC3306475
Pruetz, J., Detterich, J., Trento, L. & Sklansky, M. (2011). Prenatal diagnosis of cor triatriatum sinister in association with hypoplastic left heart syndrome. Pediatric Cardiology, 32(6), 818-821.
Pruetz, J.D., Sklansky, M., Detterich, J., Korst, L.M., Llanes, A. & Chmait, R.H. (2011). Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors. Prenatal Diagnosis, 31(10), 973-977.
Sangkatumvong, S., Coates, T.D., Wood, J.C., Meiselman, H.J., Kato, R., Detterich, J.A., Bush, A. & Khoo, M.C. (2010). Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Conference Proceedings: IEEE Engineering in Medicine and Biology Society, 2010,1626-1629.
Sickle Cell Disease
Cardiovascular disease in children and young adults with sickle cell anemia
The role of blood flow in disease processes
Nitric oxide effects on blood rheology in sickle cell anemia
In sickle cell disease, irregularly shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to various parts of the body, impacting different organ systems. Affected individuals with SCD can experience a wide variability of acute and chronic health problems leading to complications such as stroke, pulmonary hypertension, or organ damage to the kidneys, liver and spleen.
Jon Detterich, MD, looks at how the red blood cell is able to transport oxygen and other nutrients to specific organ systems. By studying the red blood cells of a patient using methods that allow researchers to watch blood flowing while also measuring how the heart and blood vessels are functioning, Detterich hopes to identify new approaches for delivering therapy to the red blood cell and vascular system of the very patient they are studying.
The Detterich lab at CHLA is one of the first to focus on the nitric oxide that is produced within the red cells of patients with sickle cell disease. His goal is to discover how this nitric oxide production interacts with the blood vessels, in all of the different organ systems, in order to guide new therapies that span all the disease variability.
- Deformability analysis of sickle blood using ektacytometry.
Rabai M, Detterich JA, Wenby RB, Hernandez TM, Toth K, Meiselman HJ, Wood JC. Biorheology. 2014; 51(2-3):159-70. doi: 10.3233/BIR-140660.
- Nitric oxide, vasodilation and the red blood cell.
Simmonds MJ, Detterich JA, Connes P.
Biorheology. 2014; 51(2-3):121-34. doi: 10.3233/BIR-140653.
- Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting.
Rabai M, Meiselman HJ, Wenby RB, Detterich JA, Feinberg J.
Biorheology. 2012; 49(5-6):317-28. doi: 10.3233/BIR-2012-0616.
- Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion.
Detterich JA, Sangkatumvong S, Kato R, Dongelyan A, Bush A, Khoo M, Meiselman HJ, Coates TD, Wood JC.
Transfusion. 2013 May;53(5):1059-68. doi: 10.1111/j.1537-2995.2012.03961.x. Epub 2012 Nov 26.
- Color M-mode sonography for evaluation of fetal arrhythmias.
Detterich JA, Pruetz J, Sklansky MS.
J Ultrasound Med. 2012 Oct; 31(10):1681-8.