Billy and Audrey L. Wilder Endowed Chair in Neurosurgery
Division Chief, Neurosurgery
Director, Neurosurgery Fellowship Program
Co-Director, Neurological Institute
Professor of Clinical Neurological Surgery, USC Keck School of Medicine
  • Summary
  • Publications
  • Research
  • Media
  • Locations

Mark D. Krieger, MD joined the Children’s Neurosurgery Center in 2002.

He previously was the Director of Pediatric Neurosurgery at the Mount Sinai School of Medicine in New York. A magna cum laude graduate of Harvard College and the College of Physicians and Surgeons of Columbia University, Dr. Krieger completed his training in Neurological Surgery at the University of Southern California, Department of Neurological Surgery.

He served as the American Association of Neurological Surgeons/Congress of Neurological Surgeons Pediatric Fellow at Hospital de la Timone in Marseille, France and completed a Fellowship in Pediatric Neurosurgery at Children’s Hospital Los Angeles. He has published over 50 peer-reviewed articles and numerous book chapters, in addition to giving over 100 talks at national meetings.

He is active in the Congress of Neurological Surgeons, American Association of Neurosurgeons and the American Society for Pediatric Neurosurgeons.

He cares for children with all surgical diseases of the brain, spinal cord, peripheral nerves and specializes in tumors of the central nervous system. Currently, Dr. Krieger serves as the Chief of Medical Staff.

Clinical Interests

Brain and spinal tumors; Chiari malformations; Intracranial cysts; Hydrocephalus

Education

Medical School: 

Columbia University, College of Physicians and Surgeons

Internship: 

Los Angeles County-University of Southern California Medical Center; Neurosurgery

Residency: 

Los Angeles County-University of Southern California Medical Center; Neurosurgery

Fellowship: 

Children's Hospital Los Angeles; Pediatric Neurosurgery

Accomplishments

Certification: 

American Board of Pediatric Neurosurgery and American Board of Neurological Surgery

Medical Memberships: 

American Society of Pediatric Neurosurgeons; American Association of Neurological Surgeons; Congress of Neurological Surgeons

Publications: 

Publications

  1. The association between dental health and procedures and developing shunt infections in pediatric patients. Moazzam AA, Nehrer E, Da Silva SL, Polido JC, Arakelyan A, Habibian M, Krieger MD., J Neurosurg Pediatr. 2014 Sep 12:1-6. [Epub ahead of print]
  2. What is the risk of infecting a cerebrospinal fluid-diverting shunt with percutaneous tapping? Spiegelman L, Asija R, Da Silva SL, Krieger MD, McComb JG., J Neurosurg Pediatr. 2014 Oct;14(4):336-9. doi: 10.3171/2014.7.PEDS13612. Epub 2014 Aug 8.
  3. Deep brain stimulation evoked potentials may relate to clinical benefit in childhood dystonia. Bhanpuri NH, Bertucco M, Ferman D, Young SJ, Liker MA, Krieger MD, Sanger TD., Brain Stimul. 2014 Sep-Oct;7(5):718-26. doi: 10.1016/j.brs.2014.06.003. Epub 2014 Jun 25.
  4. A retrospective analysis of recurrent intracranial ependymoma. Antony R, Wong KE, Patel M, Olch AJ, McComb G, Krieger M, Gilles F, Sposto R, Erdreich-Epstein A, Dhall G, Gardner S, Finlay JL., Pediatr Blood Cancer. 2014 Jul;61(7):1195-201. doi: 10.1002/pbc.24996. Epub 2014 Feb 24.
  5. PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol AS, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharazadeh S., Clin Cancer Res. 2014 Feb 15;20(4):827-36. doi: 10.1158/1078-0432.CCR-13-2053. Epub 2013 Dec 3.
Research Interests: 

Mark-Krieger-Banner1.jpg

Research Topics 

  • Pediatric Brain Tumors

  • Spinal Cord Tumors

Research Overview

Pediatric brain tumors are difficult to understand because they behave differently than adult tumors. The overarching goal our research is to make surgery obsolete. We want to cure these brain tumors, without causing injury to the child in the process. Twenty years ago, children with brain tumors received high doses of radiation therapy, which would kill the tumor, but would also cause significant negative impact to the patient’s cognitive ability. Today, we strive to find the least toxic therapy that we can give these kids that will cure these tumors at a high rate, but not cause damage to the brain.

This involves looking at differentiating types of tumors and figuring out the best therapies that are tailored to each type of tumor. This is more of a personalized medicine approach. We try to target surgery, chemotherapy, radiation therapy to really treat our patients in the best way possible based on each child’s specific disease.

One new area is functional neurosurgery, which looks at the brain as a collection of electrical or chemical circuits of the brain that helps us learn and develop as individuals. Sometimes when these circuits go awry, they can cause disease. We are just getting started on how to modulate these pathways so we can help our patients live full and productive lives. We are starting a surgical epilepsy program so tailor surgical procedures to patients that have seizures and are not responding to medication. We are also starting up a movement disorder clinic. A lot of our patients are born with cerebral palsy or spasticity where they have a hard time moving and they are actually locked in their bodies. They may have a normal brain, but this movement disorder means they are unable to move and express themselves. We’re learning about this by putting electrodes to the brain and stimulating different parts of the brain and modulating the pathways of these circuits.

We are trying to get an understanding of how the brain works essentially. We are trying to see the how the different areas of the brain interact with, and impact each other and trying to find ways to modulate those pathways to actualize the potential of all of our patients. For example, if a child’s brain doesn’t function properly to allow a child’s body to move in normal ways, we’re trying to change the modulation of the different pathways so that the body is free to move normally.

We have a large team of neuro-oncologists, neuro-patholigists, neuro-radiologists, neurologists and psychiatrists and other health care professionals who work together to take care of our patients and we have been able to achieve high results. Our goal is to try and bring our physicians together to be able to solve issues and create opportunities to bring hope. Some of these tumors that were incurable 10 years ago now have a high rate of cure. One of the most common malignant types of tumor that had a 50% survival rate now has a better than 90% survival rate.

In The News- Press Releases

.

4650 Sunset Blvd.
MS #102
Los Angeles, CA 90027
Phone: 323-361-2169Office
Fax: 323-361-3101Fax