Translational Biomedical Imaging Laboratory - TBIL

About Us

Using imaging technologies to observe the natural course of biology in action within living organisms will help accelerate the development of new diagnostics and treatments. The Translational Biomedical Imaging Laboratory (TBIL) provides dynamic imaging equipment and technical expertise to accelerate scientific discovery trajectory from bench to bedside and is currently collaborating on studies that include intestinal stem cell propagation, neuroblastoma, and heart regeneration. TBIL is a research accelerator that brings unites clinicians and researchers who are defining the basic mechanisms that build organs to design better therapies.

Bioimaging includes powerful, innovative tools for studying biological processes—such as confocal microscopes that can image virtually any specimen on a slide or culture dish, live-cell imaging, and in-vivo fluorescence imaging.  Additionally, confocal laser scanning microscopy allows investigators to acquire in-focus images from selected depths, a process known as optical sectioning. Images are then acquired point by point and reconstructed with a computer, allowing three-dimensional reconstructions of topologically complex structures. All of these methods hold enormous potential for a wide variety of diagnostic and therapeutic applications.

Agenda / Mission Statement

The mission of TBIL is to develop new technologies and provide experimental design advice for the imaging of biological structure and function. To explore varied research topics, TBIL researchers employ advanced imaging tools to follow events as they take place inside an intact organism. Some of these technologies include conventional fluorescence and bioluminescence imaging, laser microscopy (confocal, multiphoton, light-sheet, super-resolution, lifetime, hyperspectral phaser analysis), Optical Coherence Tomography, Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) microscopy. These methods continue to yield unique longitudinal data and insightful tests of proposals made from molecular or cell culture data. As these technologies mature, TBIL makes them available to the CHLA and USC research community members, serving dual, complementary roles as a research center and a user facility.

  • Industry and Academic Collaborations & Partnerships
  • Submitting Projects for Consideration
  • TBIL Events Calendar
  • Projects
  • Gallery
  • Publications
  • Resources
  • Training / Education
  • California Institute of Technology
  • University of California, San Diego
  • University of California, Los Angeles
  • University of Southern California
  • City of Hope
  • Cedars-Sinai Medical Center
  • Children’s Hospital of Philadelphia
  • University of Pittsburgh
  • Mayo Clinic
  • Allergan
  • Imbio, LLC
  • Fluidda Inc.
  • 4D Medical
  • Submit a Project Plan (link below)
  • Schedule a TBIL Talk
  • Receive Feedback/Acceptance
  • Define and Sign TBIL Collaboration Agreement

We encourage Principal Investigators (PI) to contact TBIL and provide details of their project. Please visit the following link to provide the details of the project: https://forms.office.com/r/XamRgpb4V7. Once we review the projects, we will contact you to discuss the feasibility, training, and approvals required to manage and establish formal collaboration.

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Fantastic Voyage to the Lung

Using newly optimized visualization technology at TBIL, researchers can now perform a ‘virtual bronchoscopy’ that begins in the bronchus and allows them to peer into the alveolus. In a collaboration led by David Warburton, MD, researchers are seeking to radically transform our understanding of the formation of the gas exchange surface in the human lung, find new approaches to the care of premature infants, and develop a better understanding of the numerous childhood- and adult-onset lung diseases. The research team was awarded $4 million by the NIH (2014) to map the developing lung.

(Update coming soon)

(Update coming soon)

TBIL Members

The Translational Biomedical Imaging Laboratory Members

Member Title/Position
Scott E. Fraser, PhD Co-Director Principal Investigator TSRI; Provost Professor & Director of Science Initiatives, USC
Rex A. Moats, PhD Co-Director Principal Investigator TSRI, Director of Research Radiology CHLA; Associate Professor of Research Radiology, KSOM USC
Marvin Nelson, MD, MBA Chair of Radiology, CHLA
Cristina Zavaleta, PhD Assistant Professor of Biomedical Engineering, USC
Rusty Lansford, PhD Principal Investigator TSRI; Associate Professor of Research Radiology, KSOM USC
David S. Koos, PhD TBIL Technical Director
Dnyanesh N. Tipre, PhD TBIL Project Coordinator
Harvey A. Pollack, MD Director of Small Animal Imaging Core, CHLA
Seth Ruffins, PhD Optical Imaging Facility Director, Eli & Edythe Broad CIRM Center, KSOM USC
Jason A. Junge, PhD Director of Imaging Services, Advanced Light Microscopy Core, USC
Martin Broome, PhD Corporate Collaborations Manager, Office of Technology Commercialization, CHLA