COVID-19 Research

As a research institution focused on pediatric health and disease, Children’s Hospital Los Angeles is uniquely positioned to study how the novel coronavirus disease (COVID-19) affects our nation’s children. A number of studies are currently underway, and others  are in the planning stages—from the biology of the disease to new ways to care for children and families during this pandemic.

 

Published on July 20, 2020
CHLA-COVID-19-Research-1200x628-01.jpg
From basic research to epidemiological data, investigators in The Saban Research Institute of Children’s Hospital Los Angeles are taking on COVID-19 research from multiple directions. 
Published on June 3, 2020
CHLA-COVID19-Research-Chang-1200x628-01.jpg
In the face of the COVID-19 pandemic, changes must be made to how patients are resuscitated. Normal procedures such as intubation and CPR can allow viruses to spread.  The American Heart Association has provided changes to prior guidelines to reduce or eliminate the amount of... Read More
Published on June 2, 2020
CHLA-COVID19-Research-Bard-1200x628-01.jpg
Patients of different ages and ethnicities, from a range of geographic locations, have been exhibiting varying types of illness and symptom severity due to COVID-19. While children were initially thought to be less affected by the disease than adults, they can recover from... Read More
Published on June 1, 2020
CHLA-COVID19-Research-Espinoza-1200x628-01.jpg
COVID-19 has required changes in every level of patient care as the nation strives to maintain safe intrapersonal distance. One way Children’s Hospital Los Angeles has addressed this issue is through the development and use of chatbots—software applications that mimic spoken... Read More
Published on May 31, 2020
CHLA-COVID19-Research-Khemani-1200x628-01.jpg
In the most severe cases of COVID-19, patients suffer from acute respiratory distress syndrome (ARDS), which can be fatal. Ventilator management in ARDS is complicated, and randomized trials have demonstrated that failure to provide good lung-protective ventilation results in... Read More
Published on May 30, 2020
CHLA-COVID19-Research-Neely-1200x628-01.jpg
Early reports suggested that hydroxychloroquine (HCQ), a drug used to prevent malaria and treat children with certain rheumatologic conditions like lupus, may relieve inflammation associated with moderate or severe COVID-19. Michael Neely, MD, MSc, was lead investigator on a... Read More
Published on May 29, 2020
CHLA-COVID19-Research-Precit-1200x628-01.jpg
To fight a disease that is affecting the entire world, the disease must be better understood. Scientists and clinicians need data about the disease spectrum, optimal sample types for testing, and duration of virus shedding. Unfortunately, this type of information is quite... Read More
Published on May 28, 2020
CHLA-COVID19-Research-Shi-1200x628-01.jpg
COVID-19 is caused by the novel coronavirus, SARS-CoV-2, infecting the respiratory system. Specifically, the spike protein (S1 subunit) of the virus binds to a protein receptor called angiotensin converting enzyme 2 (ACE2) on lung epithelial cells. This interaction is a key step... Read More
Published on May 27, 2020
CHLA-COVID19-Research-Szymanski-1200x628-01.jpg
Since the onset of the COVID-19 pandemic, scientists and clinicians have sought to better understand the virus and how it spreads. Analysis of antibodies developed against the coronavirus can offer insight into timing and extent of illness.
Published on May 26, 2020
CHLA-COVID19-Research-Yau-1200x628-01.jpg
The COVID-19 pandemic is a major stressor in the lives of the global community, but perhaps greatest for adolescents and young adults, who don’t always have resources to help them cope. To assess psychosocial stress and coping in adolescents, Ji-Ting Janet Yau, DO, has developed... Read More