CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Study Details - ID: CHLA-21-00016
Health/Science/Disease Category:
Ulcerative Colitis (UC)
Purpose of Research:
To evaluate the efficacy of tofacitinib based on remission in pediatric participants with moderately to severely active UC.
Short Name:
Pfizer OVATION Protocol A3921210
Full Title of Study:
OPEN-LABEL INDUCTION AND MAINTENANCE STUDY OF ORAL CP-690,550 (TOFACITINIB) IN CHILDREN WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS
Phase/Type of Study:
Phase 3
Eligibility:
Males and Females between the ages of 2 and 17 years old, UC diagnosis, moderate to severely active UC as defined by Mayo Score and PUCAI, an inadequate response to TNF inhibitors, and no history of TB, colectomy, or certain UC treatments.
Time Commitment/Requirements:
Participants will be provided with the study drug to take 2 times every day for at least a 12 month period and are expected to have multiple study visits. Daily questionnaires are to be completed. Compensation will be provided.
Primary Investigator:
Dr. Sonia Michail
Coordinator Contact Name:
Ronald Martinez Galan
Phone Number:
323-361-3402
Email:
rmartinezgalan@chla.usc.edu
Clinical Trials .Gov Identifier:
NCT04624230