CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Study Details - ID: CHLA-20-00424
Health/Science/Disease Category:
Sepsis/ Emergency Medicine
Purpose of Research:
To find out which of two commonly used IV fluids given in the Emergency Department for sepsis is most effective
Short Name:
Full Title of Study:
PRagMatic Pediatric Trial of Balanced vs. normal Saline Fluid in Sepsis
Phase/Type of Study:
Phase III Randomized Control Trial  
Any child who is older than 6 months and less than 18 years of age, and is suspected to have sepsis by their medical team in the emergency department
Time Commitment/Requirements:
The study will take place for 4.5 years. Focus groups will be held to provide information, answer questions, and get community member's thoughts and feelings about the study. If you are interested in attending a focus group, email the study team. If you do not want your child to participate, email the study team to request to add your child's name to an "opt out" list and to receive an "opt out" bracelet for your child to wear.
Primary Investigator:
Ara Festekjian, MD, MS
Coordinator Contact Name:
Sharon Tang
Phone Number:
Clinical Trials .Gov Identifier: